Impacts of inflammatory cytokines on depression: a cohort study

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Март 8, 2024

Abstract Background Inflammatory factors are associated with depression. We seek to investigate the correlation between inflammatory cytokines and prognosis of depression or suicidal ideation behavior at 3 months in patients. Methods Eighty-two depressed outpatients were recruited treated as usual. Plasma measured baseline. Patients followed up Patient Health Questionnaire-9 according item Hamilton scale for months. Results Compared patients low level interleukin-1β, high one had severe depressive symptoms month 2 (B 0.92, P < 0.01; B 0.86, = 0.02; respectively). The incidence was 18.3% Depression levels tumor necrosis factor-α showed risk than (OR 2.16, 95% CI 1.00-4.65, 0.04). Conclusions High interleukin-1β predictive middle-term respectively.

Язык: Английский

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Molecular mechanisms underlying cyclophosphamide-induced cognitive impairment and strategies for neuroprotection in preclinical models

Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(8), С. 1873 - 1893

Опубликована: Июль 31, 2023

Cyclophosphamide has drastically enhanced the expectancy and quality of life cancer patients. However, it is accompanied by diverse neurological complications which are considered a dose-limiting adverse effect. Neurotoxicity caused cyclophosphamide can manifest in numerous manners including anxiety, depression, motor dysfunction cognitive deficits. This review article offers an overview on cyclophosphamide-induced neurotoxicity, providing unified point view possible underlying molecular mechanisms oxidative brain damage, neuroinflammation, apoptotic neuronal cell death as well disruption balance neurotransmitters neurotrophic factors. Besides, this sheds light promising protective agents that have been investigated using preclinical animal models their biological targets protection mechanisms. Despite results experimental models, none these studied clinical trials. Thus, there lack evidence to advocate use any neuroprotective agent setting. Furthermore, evaluated for its effect anticancer activity tumor-bearing animals. Therefore, great necessity adequate well-designed studies evaluation therapeutic values candidates. Conclusively, summarizes accounting neurotoxicity together with potential strategies seeking downgrading complication, thus enhancing well-being patients treated cyclophosphamide.

Язык: Английский

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Ultrasound-assisted hydrogen peroxide–ascorbic acid method to degrade sweet corncob polysaccharides can help treat type 2 diabetes via multiple pathways in vivo

Ultrasonics Sonochemistry, Год журнала: 2023, Номер 101, С. 106683 - 106683

Опубликована: Ноя. 7, 2023

In this study, we aimed to investigate the impact of various ultrasound durations on structure and bioactivity sweet corncob polysaccharides treated with ultrasound-assisted degradation using hydrogen peroxide ascorbic acid (H2O2-Vc). We subjected treatment for 0, 30, 60, 90 min alongside H2O2-Vc method. then analyzed their chemical composition structure. Additionally, administered these mice type 2 diabetes (T2DM) through gavage at a dosage 200 mg/kg/day. The results indicated significant reduction in molecular weight degraded polysaccharides, while remained relatively stable. However, basic was retained. vivo experiments demonstrated that had positive T2DM, particularly 60-minute (UH-DSCBP-60 min), which effectively controlled blood glucose levels by regulating glycolipid metabolism livers T2DM. This approach also reduced inflammation oxidative stress inhibited disaccharide activity small intestine. can positively affect hypoglycemic activity. findings our study provide theoretical foundation valuable utilization polysaccharides.

Язык: Английский

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Geraniol prevents CCl4-induced hepatotoxicity via suppression of hepatic oxidative stress, pro-inflammation and apoptosis in rats

Toxicology Reports, Год журнала: 2024, Номер 12, С. 128 - 134

Опубликована: Янв. 21, 2024

Carbon tetrachloride (CCl4) is a classic chemical hepatotoxicant that triggers liver damage through hepatic exacerbation of oxidative stress. Geraniol (GRL) natural bioactive acyclic monoterpene with several pharmacological effects. We thus explored whether GRL could prevent CCl4-triggered toxicity. Rats were divided and administered (100 mg/kg) and/or CCl4 (1 ml/kg 1:1 v/v CCl4: olive oil) in Control group, + groups 2 times per week for 4 consecutive weeks. caused significantly (p < 0.05) elevated serum activities alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine (ALT), total bilirubin (TB), whereas the albumin (ALB) protein (TP) levels reduced relative to control group. The catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) decreased 0.05), while malondialdehyde (MDA) level evidently comparison exposure significant increases proinflammatory interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α), apoptotic caspase-3 caspase-9 levels, anti-inflammatory interleukin-4 (IL-4) interleukin-10 (IL-10) consistent histopathological changes compared control. On contrary, administration prevented toxicity lesions restoration status markers, antioxidant enzyme activities, MDA, cytokines apoptosis Altogether, findings reveal abrogate CCl4-provoked via inhibition stress, inflammation rats.

Язык: Английский

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Targeting SIRT1/AMPK/Nrf2/NF-кB by sitagliptin protects against oxidative stress-mediated ER stress and inflammation during ANIT-induced cholestatic liver injury

Toxicology, Год журнала: 2024, Номер 507, С. 153889 - 153889

Опубликована: Июль 18, 2024

Язык: Английский

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LC-qTOF-MS/MS phytochemical profiling of Tabebuia impetiginosa (Mart. Ex DC.) Standl. leaf and assessment of its neuroprotective potential in rats

Journal of Ethnopharmacology, Год журнала: 2024, Номер 331, С. 118292 - 118292

Опубликована: Май 3, 2024

Язык: Английский

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Epicatechin ameliorates glucose intolerance and hepatotoxicity in sodium arsenite-treated mice

Food and Chemical Toxicology, Год журнала: 2024, Номер 192, С. 114950 - 114950

Опубликована: Авг. 24, 2024

Язык: Английский

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In Vivo and Computational Studies on Sitagliptin’s Neuroprotective Role in Type 2 Diabetes Mellitus: Implications for Alzheimer’s Disease

Brain Sciences, Год журнала: 2024, Номер 14(12), С. 1191 - 1191

Опубликована: Ноя. 26, 2024

Background/Objectives: Diabetes mellitus (DM), a widespread endocrine disorder characterized by chronic hyperglycemia, can cause nerve damage and increase the risk of neurodegenerative diseases such as Alzheimer’s disease (AD). Effective blood glucose management is essential, sitagliptin (SITG), dipeptidyl peptidase-4 (DPP-4) inhibitor, may offer neuroprotective benefits in type 2 diabetes (T2DM). Methods: T2DM was induced rats using nicotinamide (NICO) streptozotocin (STZ), biomarkers AD DM-linked enzymes, inflammation, oxidative stress, apoptosis were evaluated brain. Computational studies supported vivo findings. Results: SITG significantly reduced brain enzyme levels acetylcholinesterase (AChE), beta-secretase-1 (BACE-1), DPP-4, glycogen synthase kinase-3β (GSK-3β) T2DM-induced rats. It also inflammation lowering cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), nuclear factor-κB (NF-κB). Additionally, improved stress markers reducing malondialdehyde (MDA) enhancing glutathione (GSH). increased anti-apoptotic B-cell lymphoma protein-2 (Bcl-2) while pro-apoptotic Bcl-2-associated X (BAX) Caspace-3. lowered plasma insulin levels. To explore potential molecular level mechanisms, docking performed on AChE, COX-2, GSK-3β, BACE-1, The binding affinity for above-mentioned target enzymes 10.8, 8.0, 9.7, 7.7, 7.9 kcal/mol, respectively, comparable to co-crystallized ligands. Further mode analysis lowest energy conformation revealed interactions with critical residues. Conclusions: These findings highlight SITG’s targets T2DM-associated neurodegeneration its therapeutic approach AD, warranting further clinical investigations.

Язык: Английский

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Roflumilast attenuates doxorubicin and cyclophosphamide combination-induced chemobrain in rats through modulation of NLRP3/ASC/caspase-1/GSDMD axis

Life Sciences, Год журнала: 2025, Номер 362, С. 123378 - 123378

Опубликована: Янв. 7, 2025

Язык: Английский

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Kidney protective effect of sitagliptin in 5-fluorouracil-challenged rats

Pharmacia, Год журнала: 2024, Номер 71, С. 1 - 5

Опубликована: Фев. 27, 2024

The possible protective effect of sitagliptin (SIT) against nephrotoxicity induced by a single dose 5-fluorouracil (5-FU) (150 mg/kg, i.p.) was investigated in rats. SIT treatment (5 and 10 mg/kg/day, p.o.) given for 7 days, starting 5 days before 5-FU administration. Both doses caused significant reductions serum creatinine neutrophil gelatinase-associated lipocalin levels rats received 5-FU. also significantly decreased malondialdehyde, tumor necrosis factor-α, interleukin-1β, nuclear factor-κB p65 (NF-κB p65), Bax/Bcl-2 ratio, cleaved caspase-3 kidneys 5-FU-challenged Additionally, SIT, at both doses, increased renal total antioxidant capacity factor erythroid 2related 2 (Nrf2) Besides, markedly attenuated the 5-FU-induced histopathological kidney tissue injury It concluded that provided nephroprotective rats, through its antioxidant, antiinflammatory, antiapoptotic activities, modulating Nrf2 NF-κB pathways.

Язык: Английский

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