Antivirals and Biologics for Broader Coverage Against Human Coronaviruses DOI Open Access

Mia Outteridge,

Christine M. Nunn,

Kevin M. Devine

и другие.

Опубликована: Дек. 12, 2023

Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a genome 27-31kbases in length. Critical genes include the spike (S), envelope (E), membrane (M), nucleocapsid (N) and 9 accessory open reading frames encoding for non-structural proteins (NSPs) that have multiple roles replication cycle immune evasion (1). There 7 known human CoVs most likely appeared after zoonotic transfer, recent being SARS-CoV-2 responsible Covid-19 pandemic. Antivirals been approved by FDA use against such as Paxlovid can potentially target successfully inhibit main protease (MPro) activity of CoVs, however alternative proteomes encoded CoV genomes closer genetic similarity to each other, suggesting antivirals could be developed now future CoVs. New introductions humans inevitable unpredictable. Therefore, new required control not only next outbreak, but also 4 common (229E, OC43, NL63, HKU1) circulate frequently contain sporadic outbreaks severe (SARS-CoV, MERS SARS-CoV-2). The current study found emerging antiviral drugs, Paxlovid, proven SARS-CoV-2. Other drugs which potential other still within clinical trial yet available public use. Monoclonal antibody (mAb) treatment vaccines reduce mortality hospitalisation rates, they Spike protein whose sequence mutates drifts. is applicable targeting HCoVs these well conserved sequences among Thus, there need readily treatments globally all improve preparedness outbreaks. Here we discuss research contributing transmission, including outbreak. aim was identify features antivirals, biologics scientific, political, economic health strain caused future.

Язык: Английский

Engineered two-dimensional nanomaterials based diagnostics integrated with internet of medical things (IoMT) for COVID-19 DOI
Mohd. Abubakar Sadique, Shalu Yadav, Raju Khan

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(8), С. 3774 - 3828

Опубликована: Янв. 1, 2024

Engineered 2D nanomaterials-based smartphone-assisted detection approaches integrated with IoMT, focusing on reliable, sensitive, and rapid diagnostics for COVID-19.

Язык: Английский

Процитировано

7
Nanoparticle-neutrophils interactions for autoimmune regulation DOI Creative Commons
Daniel Kupor, Michael L. Felder,

Shivanie Kodikalla

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 209, С. 115316 - 115316

Опубликована: Апрель 23, 2024

Neutrophils play an essential role as 'first responders' in the immune response, necessitating many immune-modulating capabilities. Chronic, unresolved inflammation is heavily implicated progression and tissue-degrading effects of autoimmune disease. modulate disease pathogenesis by interacting with inflammatory autoreactive cells through effector functions, including signaling, degranulation, neutrophil extracellular traps (NETs) release. Since current gold standard systemic glucocorticoid administration has drawbacks side effects, targeting neutrophils autoimmunity provides a new approach to developing therapeutics. Nanoparticles enable specific cell types controlled release loaded drug cargo. Thus, leveraging nanoparticle properties interactions exciting direction toward novel therapies for diseases. Additionally, recent work utilized design targeted particles delivery into previously inaccessible areas. Here, we outline nanoparticle-based strategies activity autoimmunity, various formulations neutrophil-derived targeting.

Язык: Английский

Процитировано

7
Durable cross-protective neutralizing antibody responses elicited by lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccines DOI Creative Commons
Ki Hyun Bae, Bhuvaneshwari D O Shunmuganathan, Li Zhang

и другие.

npj Vaccines, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 23, 2024

Abstract The advent of SARS-CoV-2 variants with defined mutations that augment pathogenicity and/or increase immune evasiveness continues to stimulate global efforts improve vaccine formulation and efficacy. extraordinary advantages lipid nanoparticles (LNPs), including versatile design, scalability, reproducibility, make them ideal candidates for developing next-generation mRNA vaccines against circulating variants. Here, we assess the efficacy LNP-encapsulated booster encoding spike protein concern (Delta, Omicron) using a predecessor (YN2016C isolated from bats) strain elicit durable cross-protective neutralizing antibody responses. mRNA-LNP have desirable physicochemical characteristics, such as small size (~78 nm), low polydispersity index (<0.13), high encapsulation efficiency (>90%). We employ in vivo bioluminescence imaging illustrate capacity our LNPs induce robust expression secondary lymphoid organs. In BALB/c mouse model, three-dose subcutaneous immunization mRNA-LNPs achieved remarkably levels cross-neutralization Omicron B1.1.529 BA.2 extended periods time (28 weeks) good safety profiles all constructs when used regime, YN2016C bat virus sequences. These findings important implications design aim trigger immunity current newly emerging

Язык: Английский

Процитировано

6
HTLV-1 vaccination Landscape: Current developments and challenges DOI Creative Commons
Arash Letafati,

Mahshid Bahari,

Omid Salahi Ardekani

и другие.

Vaccine X, Год журнала: 2024, Номер 19, С. 100525 - 100525

Опубликована: Июль 14, 2024

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that distinguished for its correlation to myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). As well, HTLV-1 has been documented have links with other inflammatory diseases, such as uveitis dermatitis. According the World Health Organization (WHO), global distribution of infection estimated extend between 5 10 million individuals. Recent efforts in vaccine development primarily involve selecting viral components, antigens, from structural non-structural proteins. These components are chosen trigger vigorous immune response cytotoxic T lymphocytes (CTLs), helper (HTLs), B cells. Investigation into developing against ongoing, current surveys explored several approaches, including vector vaccines, DNA protein peptide dendritic cell-based mRNA platforms. Despite these investigations shown promising results, challenges like necessity long-term protective immunity, addressing diversity, managing potential side effects remain. It critical keep track progress made vaccination research comprehend status possible impacts. The evolving nature underscores importance staying informed about advancements we strive combat HTLV-1-associated diseases through effective strategies. In this review, our goal provide an overview efforts, emphasizing progress, challenges, future directions vital area research.

Язык: Английский

Процитировано

3
A Reverse Transcription Nucleic-Acid-Based Barcoding System for In Vivo Measurement of Lipid Nanoparticle mRNA Delivery DOI Creative Commons
Ke Wang, Tiana L. Young,

Jingan Chen

и другие.

ACS Bio & Med Chem Au, Год журнала: 2025, Номер 5(1), С. 35 - 41

Опубликована: Фев. 5, 2025

Lipid nanoparticles (LNPs) are the most extensively validated clinical delivery vehicles for mRNA therapeutics, exemplified by their widespread use in COVID-19 vaccines. The pace of lipid nanoparticle (LNP) development therapeutics is restricted limitations existing methods large-scale LNP screening. To address this challenge, we developed Quantitative Analysis Reverse Transcribed Barcodes (QuART), a novel nucleic-acid-based system measuring functional vivo. QuART uses bacterial retron reverse transcription to couple into cytoplasm with cDNA barcode readout. Our results demonstrate that can be used identify both vitro cell culture and vivo mice. Multiplexing could enable high-throughput screening formulations, facilitating rapid discovery promising candidates therapeutics.

Язык: Английский

Процитировано

0
Development and efficacy of a novel mRNA cocktail for the delivery of African swine fever virus antigens and induction of immune responses DOI Creative Commons
Xing Hu,

Cong Liu,

Nino Rcheulishvili

и другие.

Microbiology Spectrum, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

ABSTRACT African swine fever (ASF) is a highly lethal infectious disease affecting pigs. Although several vaccine formulations have been developed to protect from ASF virus (ASFV) infection, none yet provided complete protection without side effects or the risk of progressing chronic infection. mRNA vaccines offer unparalleled advantages in terms safety and ability induce immune responses. In this study, we designed six encoding key antigenic proteins ASFV- B602L, CD2V, EP153R, P30, P54, P72 combined them into an cocktail for vaccination mice Our findings suggest that capable provoking robust multivalent humoral cellular responses while maintaining favorable profile. Thus, it may serve as potential approach controlling transmission, contributing ongoing efforts develop effective safe ASFV vaccines. The administration induced both pigs, suggesting future development. IMPORTANCE This study explores critical antigens (B602L, P72), demonstrating its innovative serves significant advancement development by addressing efficacy concerns. represents step forward research strategy holds promise control offering possibly safer more alternatives conventional could significantly impact management prevention strategies globally, ultimately benefiting animal health reducing economic losses.

Язык: Английский

Процитировано

0
Lipid nanoparticles driving mRNA vaccine innovations: From concept to clinic DOI
Amirali Hariri, Mina Mirian, Atefeh Zarepour

и другие.

Applied Materials Today, Год журнала: 2025, Номер 44, С. 102786 - 102786

Опубликована: Май 19, 2025

Процитировано

0
The mRNA vaccine contributors: Assessing their impact through a mainstream lens DOI
Mei Hsiu‐Ching Ho, John S. Liu, Weiping Wang

и другие.

Technological Forecasting and Social Change, Год журнала: 2025, Номер 218, С. 124200 - 124200

Опубликована: Май 22, 2025

Язык: Английский

Процитировано

0
Multi-physiology modeling of the immune system in the era of precision immunotherapy DOI Creative Commons

Sung-Hyun Hong,

Kyemyung Park

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 29, 2025

Immunotherapies using new modalities, including antibody-based drugs, nanoparticle-delivered and adoptive cell therapy, have become major treatment options for immune-related diseases such as cancer, autoimmune diseases, infections. Although data characterizing individual patients’ pharmacological responses, immune statuses, clinical outcomes increasingly available, predicting immunotherapeutic responses developing deploying optimal immunotherapies remains challenging. Here, we propose “multi-physiology modeling” of the system that integrates omics-based dynamic systems modeling-based immunology pharmacometrics modeling on top basic immunology. The multi-physiology approach aims to integrate different physiological realistically simulate multi-scale complex interactions under intervention by agents predictive tailored patients. This will accelerate not only our understanding related but also efficiency accuracy immunotherapeutics in era precision immunotherapy.

Язык: Английский

Процитировано

0
Impact of vaccination and non-pharmacological interventions on COVID-19: a review of simulation modeling studies in Asia DOI Creative Commons
Karan Thakkar, Júlia Spinardi, Jingyan Yang

и другие.

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Сен. 25, 2023

Epidemiological modeling is widely used to offer insights into the COVID-19 pandemic situation in Asia. We reviewed published computational (mathematical/simulation) models conducted Asia that assessed impacts of pharmacological and non-pharmacological interventions against their implications for vaccination strategy.A search PubMed database peer-reviewed, published, accessible articles English was performed up November 2022 capture studies Asian populations based on outcomes pandemic. Extracted data included model type (mechanistic compartmental/agent-based, statistical, both), intervention (pharmacological, non-pharmacological), procedures parameterizing age. Findings are summarized with descriptive statistics discussed terms evolving situation.The literature identified 378 results, which 59 met criteria extraction. China, Japan, South Korea accounted approximately half studies, fewer from South-East Mechanistic were most common, either compartmental (61.0%), agent-based (1.7%), or combination (18.6%) models. Statistical applied less frequently (11.9%). Pharmacological examined 59.3% considered vaccination, except one study an antiviral treatment. Non-pharmacological also 84.7% studies. Infection, hospitalization, mortality 91.5%, 30.5%, 30.5% respectively. Approximately a third age, including 10 mortality. Four these emphasized benefits prioritizing older adults under conditions limited supply; however, noted potential infection rates early younger adults. Few (5.1%) impact among children.Early pandemic, helped mitigate health burden COVID-19; indicates high population coverage effective vaccines will complement reduce reliance such interventions. Thus, increasing maintaining immunity levels through regular booster shots, particularly at-risk vulnerable groups, adults, might help protect public health. Future efforts should consider new alternative therapies alongside virus varied histories.

Язык: Английский

Процитировано

6