Hidden role of microglia during neurodegenerative disorders and neurocritical care: A mitochondrial perspective
International Immunopharmacology,
Год журнала:
2024,
Номер
142, С. 113024 - 113024
Опубликована: Авг. 31, 2024
Язык: Английский
Therapeutic Application of Traditional Chinese Medicine Targeting Heat Shock Proteins in Alzheimer’s Disease
Current Behavioral Neuroscience Reports,
Год журнала:
2025,
Номер
12(1)
Опубликована: Июнь 4, 2025
Язык: Английский
The role of heat shock protein B8 in neuronal protection against oxidative stress and mitochondrial dysfunction: A literature review
International Immunopharmacology,
Год журнала:
2024,
Номер
140, С. 112836 - 112836
Опубликована: Авг. 1, 2024
Язык: Английский
HSPB8 attenuates lipopolysaccharide‑mediated acute lung injury in A549 cells by activating mitophagy
Xinjian Zhou,
Minpeng Wang,
Menghan Sun
и другие.
Molecular Medicine Reports,
Год журнала:
2024,
Номер
30(3)
Опубликована: Июль 24, 2024
Sepsis
is
a
life‑threatening
multiple
organ
failure
disease
caused
by
an
uncontrolled
inflammatory
response
and
can
progress
to
acute
lung
injury
(ALI).
Heat‑shock
protein
B8
(HSPB8)
serves
cytoprotective
role
in
types
of
diseases;
however,
the
best
our
knowledge,
regulatory
HSPB8
sepsis‑induced
ALI
remains
unclear.
A549
human
alveolar
type
II
epithelial
cells
were
treated
with
lipopolysaccharide
(LPS)
for
24
h
simulate
model.
Cell
transfection
was
performed
overexpress
HSPB8,
mitochondrial
division
inhibitor‑1
(Mdivi‑1)
2
before
LPS
induction
assess
underlying
mechanism.
Protein
expression
evaluated
using
western
blotting
immunofluorescence
assay.
Cytokines
examined
ELISA
assay
kits
antioxidant
enzymes
their
detection
kits.
apoptosis
detected
flow
cytometry.
The
membrane
potential
JC‑1
staining.
upregulated
overexpression
attenuated
LPS‑induced
cytokine
levels,
oxidative
stress
cells.
inhibited
mitophagy
reduced
cells,
which
partly
overexpression.
Furthermore,
Mdivi‑1
decreased
inhibitory
effect
on
response,
LPS‑treated
In
conclusion,
LPS‑mediated
promoting
mitophagy,
indicating
as
therapeutic
target
ALI.
Язык: Английский
Projections from subfornical organ to bed nucleus of the stria terminalis modulate inflammation-induced anxiety-like behaviors in mice
Science Advances,
Год журнала:
2024,
Номер
10(48)
Опубликована: Ноя. 27, 2024
Peripheral
inflammation
is
closely
related
to
the
pathogenesis
of
sickness
behaviors
and
psychiatric
disorders
such
as
anxiety
depression.
The
circumventricular
organs
(CVOs)
are
important
brain
sites
perceive
peripheral
inflammatory
signals,
but
few
studies
have
reported
their
role
in
inflammation-induced
or
Using
a
mouse
model
lipopolysaccharide
(LPS)–induced
inflammation,
we
identified
previously
unreported
subfornical
organ
(SFO),
one
CVOs,
combating
anxiety.
LPS
treatment
induced
anxiety-like
mice.
Although
both
SFO
organum
vasculosum
lamina
terminalis
(a
CVO)
neurons
were
activated
after
treatment,
only
manipulating
modulated
LPS-induced
behaviors.
Activating
inhibiting
alleviated
aggravated
In
addition,
exerted
this
effect
through
glutamatergic
projections
bed
nucleus
stria
terminalis.
Manipulating
did
not
affect
Thus,
uncovered
an
active
counteracting
Язык: Английский