Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2

Free Radical Biology and Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Traditional herbal medicine: Therapeutic potential in acute gouty arthritis

Journal of Ethnopharmacology, Год журнала: 2024, Номер 330, С. 118182 - 118182

Опубликована: Апрель 15, 2024

Acute Gouty Arthritis (AGA) is characterized by a rapid inflammatory reaction caused the build-up of monosodium urate (MSU) crystals in tissues surrounding joints. This condition often associated with hyperuricemia, distinguished its symptoms intense pain, active inflammation, and swelling Traditional approaches AGA management fall short desired outcomes clinical settings. However, recent ethnopharmacological investigations have been focusing on potential Herbal Medicine (THM) various forms, exploring their therapeutic impact targets treatment. review briefly summarizes current pharmacological mechanisms THMs – including ingredients, extracts, prescriptions –in treatment AGA, discusses relevant molecular depth. The objective this study to offer extensive information reference point for exploration targeted using THMs. obtained scientific publications focused vitro vivo studies anti-AGA Medicines (THMs) conducted between 2013 2023. literature was collected from journals electronic databases, PubMed, Elsevier, ScienceDirect, Web Science, Google Scholar. retrieval analysis articles were guided keywords such as "acute gouty arthritis Chinese herbal medicine," prescription," immune cells," inflammation," NLRP3," miRNA," oxidative stress." We found that has large number targets, highlighting effectiveness through studies. ingredients can mitigate variety influencing macrophage polarization, neutrophils, T cells, natural killer (NK) addressing factors like NLRP3 inflammasome, signaling pathways, stress, miRNA multi-target interactions. properties THMs, components prescriptions, systematically summarized categorized based respective targets. phenolic, flavonoid, terpenoid alkaloid compounds are considered key improve AGA. achieve enhanced efficacy interactions multiple which main target. Nonetheless, given intricate composition traditional medicine, additional research required unravel underlying alleviate

Язык: Английский

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The uric acid lowering potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101183 - 101183

Опубликована: Янв. 1, 2025

Язык: Английский

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The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Фев. 4, 2025

Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. Recently, due to the high prevalence of hyperuricemia (HUA), numerous clinical connections between SU musculoskeletal disorders like sarcopenia, osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), osteoporosis (OP) have been identified. This review discusses mechanisms linking disorders, well associations with T2D McArdle disease, heart failure, OA, IDD, OP exercise-induced acute kidney injury (EIAKI), offering valuable insights for improved prevention treatment strategies. Mechanisms include oxidative stress, MSU (monosodium urate) crystal deposition, inflammation, factors. In adults, both age should be considered preventing while gender may directly impact muscle mass children adolescents. HUA gout risk factors OA progression, although some reports suggest otherwise. A U-shaped relationship IDD has reported, particularly Chinese men, indicating lower or higher level IDD. Maintaining within a certain range help prevent fractures. Future research, including epidemiological studies new pathogenesis findings, will further clarify diseases SU.

Язык: Английский

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Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Язык: Английский

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Effects of Colchicine on Major Adverse Limb and Cardiovascular Events in Patients With Peripheral Artery Disease

Mayo Clinic Proceedings, Год журнала: 2024, Номер 99(9), С. 1374 - 1387

Опубликована: Авг. 6, 2024

Язык: Английский

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Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Язык: Английский

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Inflammation unleashed: The role of pyroptosis in chronic liver diseases

International Immunopharmacology, Год журнала: 2024, Номер 141, С. 113006 - 113006

Опубликована: Авг. 29, 2024

Pyroptosis, a newly identified form of programmed cell death intertwined with inflammatory responses, is facilitated by the Gasdermin family's pore-forming activity, leading to lysis and release pro-inflammatory cytokines. This process double-edged sword in innate immunity, offering protection against pathogens while risking excessive inflammation tissue damage when dysregulated. Specifically, pyroptosis operates through two distinct signaling pathways, namely Caspase-1 pathway Caspase-4/5/11 pathway. In context chronic liver diseases like fibrosis cirrhosis, emerges as central contributing factor their pathogenesis. The identification characterized activation immune cells secretion cytokines such IL-1α, IL-1β, TNF-α. review explores interrelationship between inflammasome, protein complex located that recognizes danger signals initiates activation, resulting IL-1β IL-18. article delves into influence inflammasome on various disorders, specific focus molecular pathophysiological mechanisms. Additionally, potential therapeutic implications targeting for are highlighted future consideration.

Язык: Английский

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A novel zinc ferrite nanoparticle protects against MSU-induced gout arthritis via Nrf2/NF-κB/NLRP3 pathway

Life Sciences, Год журнала: 2025, Номер unknown, С. 123475 - 123475

Опубликована: Фев. 1, 2025

Язык: Английский

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Integrative analysis reveals the multilateral inflammatory mechanisms of CD14 monocytes in gout

Annals of the Rheumatic Diseases, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Gout, prevalent inflammatory arthritis caused by urate crystal deposition, involves immune cell activation, yet the precise role of CD14 monocytes in initiating response is poorly understood. This study aimed to characterise molecular and cellular landscape gout using single-cell transcriptomic analysis. Single-cell RNA sequencing was performed on peripheral blood mononuclear cells from 8 patients 6 age- sex-matched healthy controls. The findings were validated publicly available datasets. Differential gene expression pathway enrichment analyses conducted identify gout's key regulators subclusters. At level, we identified hypoxia-related pathways, including HIF1A, as interleukin-1β production gout. We also observed significant downregulation CLEC12A across all monocyte an S100Ahigh subcluster, characterized high S100A8/A9/A12 linked metabolic found drive NLRP3 CLEC7A inflammasome well prostaglandin secretion. In vitro stimulation with monosodium crystals revealed that differentially expressed genes enriched monocytes, highlighting synergistic these pathways driving inflammation. Additionally, genome-wide association study-prioritised underscored fatty acid metabolism inflammation, promoting secretion monocytes. These provide new insights into pathogenesis, particularly contribution hypoxia suggest potential therapeutic targets for precision medicine treatment.

Язык: Английский

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