miRNAs orchestration of adrenocortical carcinoma - Particular emphasis on diagnosis, progression and drug resistance

Pathology - Research and Practice, Год журнала: 2023, Номер 248, С. 154665 - 154665

Опубликована: Июль 4, 2023

Язык: Английский

---

The emerging role of miRNAs in Merkel cell carcinoma pathogenesis: Signaling pathway crosstalk

Pathology - Research and Practice, Год журнала: 2023, Номер 249, С. 154771 - 154771

Опубликована: Авг. 19, 2023

Язык: Английский

---

miRNAs as modulators of neuroinflammation and excitotoxicity: Implications for stroke therapeutics

Pathology - Research and Practice, Год журнала: 2024, Номер 253, С. 155093 - 155093

Опубликована: Янв. 1, 2024

Язык: Английский

---

Deciphering signaling pathway interplay via miRNAs in malignant pleural mesothelioma

Pathology - Research and Practice, Год журнала: 2023, Номер 252, С. 154947 - 154947

Опубликована: Ноя. 13, 2023

Язык: Английский

---

Role of long non-coding RNAs and natural products in prostate cancer: insights into key signaling pathways

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 17, 2025

Язык: Английский

---

Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 18, 2025

Abstract Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate (PCa) is unfavorable since it perilous lethal malignancy. capacity phytochemical nutraceutical chemicals repress oncogenic lncRNAs activate tumor suppressor has garnered significant attention as possible strategy diminish development, proliferation, metastasis, invasion cells. A potential technique treat enhance sensitivity cells existing conventional therapies use phytochemicals anticancer characteristics. Functional studies indicate that modulate drug resistance, stemness, invasion, angiogenesis, proliferation via interactions suppressors oncoproteins. Among them, numerous lncRNAs, such HOTAIR, PlncRNA1, GAS5, MEG3, LincRNA-21, POTEF-AS1, support development PCa through many molecular mechanisms, including modulation regulation various signal pathways like PI3K/Akt, Bax/Caspase 3, P53, MAPK cascade, TGF-β1. Other particular, MALAT-1, CCAT2, DANCR, LncRNA-ATB, ZEB1-AS1, SChLAP1, H19, key players regulating aforementioned processes. Natural substances have shown promising benefits against altering essential signaling pathways. overexpression advanced TNM stage, chemoresistance, reduced LncRNAs possess crucial clinical transitional implications PCa, diagnostic prognostic biomarkers, well medicinal targets. To impede progression beneficial target aberrant long non-coding RNAs using antisense oligonucleotides small interfering (siRNAs). This prevents them from transmitting harmful messages. In summary, several precision medicine approaches may be used rectify dysfunctional lncRNA regulatory circuits, so improving detection eventually facilitating conquest this disease. Due their presence biological fluids tissues, they serve novel biomarkers. Enhancing treatments mitigates resistance chemotherapy radiation.

Язык: Английский

---

Pasteurized Akkermansia muciniphila Timepie001 ameliorates DSS-induced ulcerative colitis in mice by alleviating intestinal injury and modulating gut microbiota

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 19, 2025

Akkermansia muciniphila (A. muciniphila), known as a next-generation probiotic, has been widely recognized for its beneficial effects in various metabolic diseases. While there is not much research whether live or pasteurized A. different on intestinal health. In the present study, strain of was isolated from healthy individuals, with and named Timepie001 Timepie001+, respectively. They were administered to dextran sulfate sodium-induced ulcerative colitis mice investigate their influences host The results showed that prophylactic supplementation alleviates symptoms by retarding weight loss, preserving tissue structure, modulating inflammatory cytokines (TNF-α, IL-1β), enhance colonic mucosal barrier upregulating expression tight junction protein Claudin-1. Interestingly, better effect compared muciniphila. Moreover, can regulates gut microbiome maintain homeostasis. This provides theoretical support widespread application postbiotics food industry.

Язык: Английский

---

Innovative perspectives on glioblastoma: the emerging role of long non-coding RNAs

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 24, 2025

Язык: Английский

---

Investigation of Some Long Noncoding RNAs (LncRNAs) in Pediatric Inflammatory Bowel Disease (IBD): An Iranian Study

Biochemistry Research International, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Introduction: According to the importance of long noncoding RNAs (LncRNA) in pathogenesis inflammatory bowel disease (IBD) and also lack study for pediatric IBD this regard, we investigated expression a selected panel LncRNAs Iranian cases compared adult healthy samples. Methods: In gene study, blood samples were taken from three groups cases, (for calibration). The UCA1, CCAT, IFNG-AS1, CDKN2B. Real-time PCR was used fold changes (FCs) reported. Results: A total 50 individuals studied including 28 IBD, 12 controls, 10 IBD. UCA1 showed upregulation (FC = 10.56, p 0.007). CCAT downregulations 0.01, < 0.001) 0.10, 0.039). IFNG-AS1 downregulation 0.001). CDKN2B 17.39, results contrast with literature. Conclusion: It seems that these may have different roles Further studies are needed on

Язык: Английский

---

A review of molecular interplay between inflammation and cancer: The role of lncRNAs in pathogenesis and therapeutic potential

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142824 - 142824

Опубликована: Апрель 1, 2025

Язык: Английский

---