Exploring the influence of non-coding RNAs on NF-κB signaling pathway regulation in ulcerative colitis DOI Open Access

Yasaman Pourmehran,

Farzad Sadri, Seyede Fatemeh Hosseini

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117390 - 117390

Published: Sept. 8, 2024

Language: Английский

miRNAs orchestration of adrenocortical carcinoma - Particular emphasis on diagnosis, progression and drug resistance DOI
Walaa A. El‐Dakroury,

Heba M. Midan,

Ahmed I. Abulsoud

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154665 - 154665

Published: July 4, 2023

Language: Английский

Citations

28
The emerging role of miRNAs in Merkel cell carcinoma pathogenesis: Signaling pathway crosstalk DOI

Nehal I. Rizk,

Heba M. Midan,

Gouda K. Helal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154771 - 154771

Published: Aug. 19, 2023

Language: Английский

Citations

24
miRNAs as modulators of neuroinflammation and excitotoxicity: Implications for stroke therapeutics DOI
Mohammed S. Elballal, Osama A. Mohammed, Mohamed Bakr Zaki

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 253, P. 155093 - 155093

Published: Jan. 1, 2024

Language: Английский

Citations

6
Deciphering signaling pathway interplay via miRNAs in malignant pleural mesothelioma DOI
Aya Salman, Sherif S. Abdel Mageed, Doaa Fathi

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 252, P. 154947 - 154947

Published: Nov. 13, 2023

Language: Английский

Citations

16
Role of long non-coding RNAs and natural products in prostate cancer: insights into key signaling pathways DOI
Ahmed S. Doghish,

Sherif S. Abdel Mageed,

Mohamed Bakr Zaki

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 17, 2025

Language: Английский

Citations

0
Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance DOI Creative Commons
Hanan Elimam, Mohamed Bakr Zaki,

Mai A. Abd‐Elmawla

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Abstract Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate (PCa) is unfavorable since it perilous lethal malignancy. capacity phytochemical nutraceutical chemicals repress oncogenic lncRNAs activate tumor suppressor has garnered significant attention as possible strategy diminish development, proliferation, metastasis, invasion cells. A potential technique treat enhance sensitivity cells existing conventional therapies use phytochemicals anticancer characteristics. Functional studies indicate that modulate drug resistance, stemness, invasion, angiogenesis, proliferation via interactions suppressors oncoproteins. Among them, numerous lncRNAs, such HOTAIR, PlncRNA1, GAS5, MEG3, LincRNA-21, POTEF-AS1, support development PCa through many molecular mechanisms, including modulation regulation various signal pathways like PI3K/Akt, Bax/Caspase 3, P53, MAPK cascade, TGF-β1. Other particular, MALAT-1, CCAT2, DANCR, LncRNA-ATB, ZEB1-AS1, SChLAP1, H19, key players regulating aforementioned processes. Natural substances have shown promising benefits against altering essential signaling pathways. overexpression advanced TNM stage, chemoresistance, reduced LncRNAs possess crucial clinical transitional implications PCa, diagnostic prognostic biomarkers, well medicinal targets. To impede progression beneficial target aberrant long non-coding RNAs using antisense oligonucleotides small interfering (siRNAs). This prevents them from transmitting harmful messages. In summary, several precision medicine approaches may be used rectify dysfunctional lncRNA regulatory circuits, so improving detection eventually facilitating conquest this disease. Due their presence biological fluids tissues, they serve novel biomarkers. Enhancing treatments mitigates resistance chemotherapy radiation.

Language: Английский

Citations

0
Pasteurized Akkermansia muciniphila Timepie001 ameliorates DSS-induced ulcerative colitis in mice by alleviating intestinal injury and modulating gut microbiota DOI Creative Commons
Huan Han, Hui Xiong, Zengli Liu

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Akkermansia muciniphila (A. muciniphila), known as a next-generation probiotic, has been widely recognized for its beneficial effects in various metabolic diseases. While there is not much research whether live or pasteurized A. different on intestinal health. In the present study, strain of was isolated from healthy individuals, with and named Timepie001 Timepie001+, respectively. They were administered to dextran sulfate sodium-induced ulcerative colitis mice investigate their influences host The results showed that prophylactic supplementation alleviates symptoms by retarding weight loss, preserving tissue structure, modulating inflammatory cytokines (TNF-α, IL-1β), enhance colonic mucosal barrier upregulating expression tight junction protein Claudin-1. Interestingly, better effect compared muciniphila. Moreover, can regulates gut microbiome maintain homeostasis. This provides theoretical support widespread application postbiotics food industry.

Language: Английский

Citations

0
Innovative perspectives on glioblastoma: the emerging role of long non-coding RNAs DOI
Ahmed S. Doghish, A. Mahmoud,

Mai A. Abd‐Elmawla

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

Language: Английский

Citations

0
Investigation of Some Long Noncoding RNAs (LncRNAs) in Pediatric Inflammatory Bowel Disease (IBD): An Iranian Study DOI Creative Commons
Fatemeh Khesali, Azizollah Yousefi, Seyyed Amir Yasin Ahmadi

et al.

Biochemistry Research International, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Introduction: According to the importance of long noncoding RNAs (LncRNA) in pathogenesis inflammatory bowel disease (IBD) and also lack study for pediatric IBD this regard, we investigated expression a selected panel LncRNAs Iranian cases compared adult healthy samples. Methods: In gene study, blood samples were taken from three groups cases, (for calibration). The UCA1, CCAT, IFNG-AS1, CDKN2B. Real-time PCR was used fold changes (FCs) reported. Results: A total 50 individuals studied including 28 IBD, 12 controls, 10 IBD. UCA1 showed upregulation (FC = 10.56, p 0.007). CCAT downregulations 0.01, < 0.001) 0.10, 0.039). IFNG-AS1 downregulation 0.001). CDKN2B 17.39, results contrast with literature. Conclusion: It seems that these may have different roles Further studies are needed on

Language: Английский

Citations

0
A review of molecular interplay between inflammation and cancer: The role of lncRNAs in pathogenesis and therapeutic potential DOI
Yan Yang, Chuxi Zhang,

H C Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142824 - 142824

Published: April 1, 2025

Language: Английский

Citations

0