Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Gouty
arthritis
is
a
prevalent
inflammatory
illness.
Gout
attacks
begin
when
there
an
imbalance
in
the
body’s
uric
acid
metabolism,
which
leads
to
urate
buildup
and
development
of
ailment.
A
family
conserved,
short
non-coding
RNAs
known
as
microRNAs
(miRNAs)
can
regulate
post-transcriptional
protein
synthesis
by
attaching
3′
untranslated
region
(UTR)
messenger
RNA
(mRNA).
An
increasing
amount
research
pointing
miRNAs
potential
players
several
diseases,
including
gouty
arthritis.
may
influence
progression
disease
regulating
immune
function
responses.
This
review
mainly
focused
on
how
they
contribute
It
also
looked
at
could
be
used
diagnostic,
prognostic,
therapeutic
targets.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2025,
Номер
44(1)
Опубликована: Фев. 22, 2025
Abstract
Background
Malignant
mesothelioma
(MM)
is
a
rare
and
aggressive
form
of
cancer
that
affects
the
mesothelial
surfaces,
associated
with
exposure
to
asbestos
fibres.
To
date,
no
cure
available
for
MM
therapeutically
approved
treatments
are
based
on
use
platinum
compounds
often
used
in
combination
other
drugs.
We
have
previously
analysed
efficacy
cisplatin/piroxicam
(CDDP/P)
combined
treatment
showing
this
was
able
reduce
vivo
tumor
growth.
Several
studies
reported
platinum-drug
sensitivity
connected
modulation
expression
non-coding
RNAs.
In
study
we
if
CDDP/P
modulate
miRNAs
MM.
Methods
miRNA
sequencing
performed
MSTO-211
H
cells
treated
CDDP
led
us
identify
miRNA-503
-
downregulated
by
as
novel
acts
an
oncomiR
The
effect
inhibition
evaluated
vitro
analysing
apoptosis
induction
reduction
properties.
Inhibition
miR-503
vivo,
ectopic
mouse
model
using
LNP
encapsulating
anti-mir-503
human
samples.
Results
analysis
confirmed
oncogene
since
its
cell
properties
growth
Its
found
upregulated
patients
compared
normal
pleura.
Bioinformatic
indicated
BTG1,
CCNG1,
EDG1,
TIMP2
putative
target
genes
miRNA-503.
These
showed
opposite
levels
both
Finally,
microarray
affected
well-known
biomarkers:
CXCL8,
SERPINE1
Osteopontin.
Conclusions
Our
first
reporting
role
suggests
inactivation
could
clinical
value
patients.
This
reveals
suggesting
inhibition,
through
delivery,
has
potential
be
considered
therapeutic
strategy
