Machine Learning Screening for Disulfidptosis Genes-Associated Immunosuppression Status in Osteosarcoma and Rhabdomyosarcoma DOI

RuiZong Wang,

J. Zhang, Kai Zhong

и другие.

Опубликована: Янв. 1, 2023

The discovery of Disulfidptosis as a novel form cell death has provided new insights for the treatment cancer and various diseases. Osteosarcoma rhabdomyosarcoma are malignant sarcomas that predominantly affect children, but molecular mechanisms underlying development these diseases remain unclear. Therefore, our study aimed to investigate involvement in both osteosarcoma rhabdomyosarcoma. To accomplish this, we analyzed bulk RNA transcriptome sequencing data obtained from Gene Expression Omnibus (GEO) datasets Therapeutically Applicable Research Generate Effective Treatments (TARGET) databases. By employing non-negative matrix factorization (NMF), successfully identified an immunosuppressive subtype based on genes associated with Disulfidptosis. Notably, this exhibited poor immune infiltration. Furthermore, employed combination 100 machine learning algorithms identify five most representative related Disulfidptosis: ACTN4, MYH9, FLNA, MYH10, IQGAP1. These played crucial role characterizing subtypes determining patient's risk score. Particularly, IQGAP1 independent prognostic effects showed promise potential therapeutic target marker. Additionally, findings suggested strong association between macrophages Disulfidptosis, which may further impact prognosis patients osteosarcoma.

Язык: Английский

Prospect of extracellular vesicles in tumor immunotherapy DOI Creative Commons

Wenbo Xia,

Yunhan Tan,

Y.-P. Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 26, 2025

Extracellular vesicles (EVs), as cell-derived small vesicles, facilitate intercellular communication within the tumor microenvironment (TME) by transporting biomolecules. EVs from different sources have varied contents, demonstrating differentiated functions that can either promote or inhibit cancer progression. Thus, regulating formation, secretion, and intake of becomes a new strategy for intervention. Advancements in EV isolation techniques spurred interest EV-based therapies, particularly immunotherapy. This review explores multifaceted various immunotherapy, highlighting their potential vaccines adoptive cell therapy. Furthermore, we explore nanoparticle delivery systems Finally, discuss current state clinical settings future directions, aiming to provide crucial information advance development application treatment.

Язык: Английский

Процитировано

0
Sophisticated roles of tumor microenvironment in resistance to immune checkpoint blockade therapy in hepatocellular carcinoma DOI Open Access
Yizhe Zhang, Yunshu Ma,

Ensi Ma

и другие.

Cancer Drug Resistance, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Hepatocellular carcinoma (HCC) remains a serious threat to global health, with rising incidence and mortality rates. Therapeutic options for advanced HCC are quite limited, the overall prognosis poor. Recent advancements in immunotherapy, particularly immune-checkpoint blockade (ICB) targeting anti-PD1/PD-L1 anti-CTLA4, have facilitated paradigm shift cancer treatment, demonstrating substantial survival benefits across various types, including HCC. However, only subset of patients exhibit favorable response ICB therapy, its efficacy is often hindered by development resistance. There many studies explore underlying mechanisms response. In this review, we compiled latest progression immunotherapies systematically summarized sophisticated which components tumor microenvironment (TME) regulate resistance therapy. Additionally, also outlined some scientific rationale strategies boost antitumor immunity enhance These insights may serve as roadmap future research help improve outcomes patients.

Язык: Английский

Процитировано

0
Epigenetic regulators combined with tumour immunotherapy: current status and perspectives DOI Creative Commons
Huan Zhang, Yuepeng Pang, Ling Yi

и другие.

Clinical Epigenetics, Год журнала: 2025, Номер 17(1)

Опубликована: Март 21, 2025

Immunotherapy, particularly immune checkpoint inhibitor therapy, has demonstrated clinical benefits in solid tumours. Despite its satisfactory efficacy, it still faces several issues, such as limited eligibility, low response rates and cytotoxicity. Cancer epigenetics implies that tumour cells exhibit unique phenotypes because of their characteristics, thus reprogramming the epigenome holds promise for cancer therapy. Epigenetic regulation plays an important role regulating gene expression during development maintenance. regulators induce cell cycle arrest, apoptosis differentiation cells, thereby exerting anti-tumour effects. Recent studies have revealed a significant correlation between epigenetic regulatory factors Epigenetics can modulate various aspects microenvironment to enhance sensitivity immunotherapy, lowering concentration required mitigating This review primarily discusses DNA methyltransferase inhibitors, histone deacetylase enhancer zeste homolog 2 inhibitors lysine-specific demethylase 1 which are associated with transcriptional repression. repression alters genes involved checkpoint, enhancing effectiveness immunotherapy. We also discuss potential challenges immunotherapy highlight advantages, application research on integrating

Язык: Английский

Процитировано

0
Cycloastragenol Inhibits Colorectal Cancer Metastasis by Attenuating the Activation of Pro-Tumor Macrophages Via Extracellular Vesicles-Mediated Glutamine-Γ-Aminobutyric Acid Metabolism DOI

Jing Zhou,

Ling Li,

Yunzhou Pu

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Characterization of Extrachromosomal Circular DNA in Primary and Cisplatin-Resistant High-Grade Serous Ovarian Cancer DOI Open Access

Youya Wang,

He Li, Qinglan Li

и другие.

Genes, Год журнала: 2025, Номер 16(5), С. 517 - 517

Опубликована: Апрель 29, 2025

Cisplatin resistance is a major cause of tumor recurrence and mortality in high-grade serous ovarian cancer (HGSOC). Extrachromosomal circular DNA (eccDNA) has emerged as critical factor evolution drug resistance. However, the specific contribution eccDNA to cisplatin HGSOC remains unclear. We performed whole-genome sequencing, Circle-Seq, RNA-Seq four pairs primary cisplatin-resistant (cisR) cell lines characterize genome-wide distribution features. Functional enrichment analyses were subsequently conducted on differentially expressed eccDNA-related genes. In SKOV3 cisR line, we identified large extrachromosomal (ecDNA) carrying HIF1A gene, which regulates repair, efflux, epithelial-mesenchymal transition, contributing Using detected total 161,062 eccDNAs, most less than 1000 bp distributed across all chromosomes. Notably, number eccDNAs chromosome 21 differed significantly between lines. Additionally, predominantly located non-coding repetitive elements. analysis genes revealed that, compared lines, associated with mitotic spindle assembly, regulation vascular permeability, differentiation. involved these pathways include MISP, WIPF1, RHOD, KRT80, PLVAP. Our findings suggest that particularly ecDNA amplifications like HIF1A, contribute mechanisms HGSOC. These insights highlight potential target for overcoming therapeutic improving treatment outcomes cancer.

Язык: Английский

Процитировано

0
Extracellular vesicles as biomarkers and drug delivery systems for tumor DOI Creative Commons
Xue Wang, Wenjing Chen, Wei Zeng

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Interactions in hepatic tumor microenvironment: Potential targets and modulations for effective therapy DOI
Farag M. A. Altalbawy, Ahmed Hussein Zwamel, Gaurav Sanghvi

и другие.

Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 156074 - 156074

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0
Interplay of Extracellular Vesicles and TLR4 Signaling in Hepatocellular Carcinoma Pathophysiology and Therapeutics DOI Creative Commons
Stavros P. Papadakos, Konstantinos Arvanitakis, Ioanna Ε. Stergiou

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2460 - 2460

Опубликована: Окт. 13, 2023

Hepatocellular carcinoma (HCC) stands as a significant contributor to global cancer-related mortality. Chronic inflammation, often arising from diverse sources such viral hepatitis, alcohol misuse, nonalcoholic fatty liver disease (NAFLD), and steatohepatitis (NASH), profoundly influences HCC development. Within this context, the interplay of extracellular vesicles (EVs) gains prominence. EVs, encompassing exosomes microvesicles, mediate cell-to-cell communication cargo transfer, impacting various biological processes, including inflammation cancer progression. Toll-like receptor 4 (TLR4), key sentinel innate immune system, recognizes both pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs), thereby triggering signaling cascades pro-inflammatory cytokine release. The intricate involvement TLR4 pathway in chronic pathogenesis is discussed study. Moreover, we delve into therapeutic potential modulating using EVs novel agents for HCC. This review underscores multifaceted role context proposes innovative avenues targeted interventions against formidable disease.

Язык: Английский

Процитировано

7
MISP Is Overexpressed in Intestinal Metaplasia and Gastric Cancer DOI Creative Commons

Tomás Vilarinho,

Diana Pádua, Bruno Pereira

и другие.

Current Oncology, Год журнала: 2024, Номер 31(5), С. 2769 - 2779

Опубликована: Май 14, 2024

Gastric cancer is the fifth most common and fourth cause of global mortality. The identification new biomarkers drug targets crucial to allow better prognosis treatment patients. mitotic spindle positioning (MISP) protein has function correcting centrosome clustering been implicated in cytokinesis migration cells. goal this work was evaluate expression clinical relevance MISP gastric cancer. evaluated by immunohistochemistry a single hospital series (n = 286) adenocarcinomas compared with normal mucosa intestinal metaplasia, preneoplastic lesion. detected on membrane 83% cases, being overexpressed 10). Its negatively associated diffuse poorly cohesive types. On other hand, it strongly expressed metaplasia where MUC2 CDX2 expression. Furthermore, when we silenced vitro, significant decrease viability carcinoma cells observed. In conclusion, cancer, an phenotype carcinogenesis having role cellular proliferation.

Язык: Английский

Процитировано

1
Extracellular Vesicles in Viral Liver Diseases DOI Creative Commons
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki

и другие.

Viruses, Год журнала: 2024, Номер 16(11), С. 1785 - 1785

Опубликована: Ноя. 17, 2024

Extracellular vesicles (EVs) are bilayer released by cells in the microenvironment of liver including parenchymal and non-parenchymal cells. They third important mechanism communications between cells, besides secretion cytokines chemokines direct cell-to-cell contact. The aim this review is to discuss role EVs viral disease, as there increasing evidence that transportation proteins, all types RNA, particles complete virions implicated pathogenesis both cirrhosis viral-related hepatocellular carcinoma. biogenesis discussed their diseases presented. Their use diagnostic prognostic biomarkers also analyzed. Most importantly, significance possible novel treatment strategies for fibrosis carcinoma presented, although available data based on experimental clinical trials have not been reported.

Язык: Английский

Процитировано

1