Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 20, 2024
Objective
The
relationship
between
post-traumatic
stress
disorder
(PTSD)
and
autoimmune
thyroid
disease
(AITD)
needs
further
evaluation.
This
study
employs
Mendelian
randomization
(MR)
to
investigate
the
causal
correlations
of
PTSD
with
thyroiditis
(AIT)
Graves’
(GD).
Methods
Datasets
for
PTSD,
AIT,
GD
were
obtained
from
FinnGen.
exposure-outcome
was
assessed
using
inverse
variance
weighted,
MR-Egger,
weighted
median.
Horizontal
pleiotropy
evaluated
through
MR-Egger
intercept,
heterogeneity
examined
Cochran’s
Q
test,
robustness
via
leave-one-out
sensitivity
analysis.
Results
MR
analysis
indicated
no
significant
AIT
(OR
0.920,
95%
CI
0.832
1.017,
p
=
0.103),
but
a
potential
increase
in
risk
associated
1.056,
1.008
1.105,
0.021).
intercept
showed
horizontal
(
>
0.05),
0.05).
Sensitivity
suggested
results
robust.
Conclusions
Evidence
an
association
genetic
liability
increased
provided,
evidence
AIT.
findings
indicate
that
individuals
may
have
likelihood
developing
GD,
underscoring
importance
research
comprehend
intricate
interplay
disorders.
Current Cancer Drug Targets,
Год журнала:
2024,
Номер
24(11), С. 1089 - 1103
Опубликована: Янв. 29, 2024
Chronic
inflammation
is
associated
with
a
prolonged
increase
in
various
inflammatory
factors.
According
to
clinical
data,
it
can
be
linked
both
cancer
and
autoimmune
diseases
the
same
patients.
This
raises
critical
question
of
how
chronic
relates
seemingly
opposing
-
tumors,
which
there
immunosuppression,
diseases,
over-activation
immune
system.
In
this
review,
we
consider
as
prerequisite
for
suppression
an
increased
likelihood
damage.
We
also
discuss
potential
disease-modifying
therapies
targeting
inflammation,
helpful
autoimmunity.
On
one
hand,
pro-inflammatory
factors
persisting
areas
stimulate
production
anti-inflammatory
due
negative
feedback
loop,
eliciting
suppression.
other
bring
baseline
immunity
closer
threshold
level
required
triggering
response
using
bystander
activation
cells.
Focusing
on
role
may
open
prospects
more
intensive
drug
discovery
inflammation.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8189 - 8210
Опубликована: Авг. 1, 2024
Ferroptosis,
a
unique
form
of
regulated
cell
death
driven
by
iron-dependent
lethal
lipid
peroxidation,
is
implicated
in
various
stress-related
diseases
like
neurodegeneration,
vasculopathy,
and
metabolic
disturbance.
Stress-related
encompass
widespread
medical
disorders
that
are
influenced
or
exacerbated
stress.
These
stressors
can
manifest
organ
tissue
systems
have
significant
implications
for
human
overall
health.
Understanding
ferroptosis
these
offers
insights
therapeutic
strategies
targeting
relevant
pathways.
This
review
explores
mechanisms,
its
role
pathophysiology,
connection
to
diseases,
the
potential
ferroptosis-targeted
nanomedicines
treating
conditions.
monograph
also
delves
into
engineering
tackling
including
cancer,
cardia-cerebrovascular,
neurodegenerative,
inflammatory
diseases.
Anyhow,
nanotherapy
holds
promise
both
promoting
suppressing
managing
Cells,
Год журнала:
2024,
Номер
13(22), С. 1906 - 1906
Опубликована: Ноя. 18, 2024
Inflammation
is
an
essential
biological
process
that
serves
as
the
body's
first
line
of
defence
against
harmful
stimuli,
including
pathogens,
damaged
cells,
and
irritants
[...].
