bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Chronic
variable
stress
(CVS)
procedures
are
widely
used
to
model
depression
in
laboratory
rodents.
We
systematically
documented
the
experimental
design
mouse
CVS
studies,
and
of
behavioural
tests
evaluate
effect
CVS.
In
a
subset
we
measured
sizes
tests.
Across
202
82%
unique
procedure.
took
advantage
this
variability
ask
whether
duration
intensity
correlated
with
effects
obtained
five
commonly-used
tests:
sucrose
preference
test
(SPT),
tail
suspension
(TST),
forced
swim
(FST),
open
field
(OFT)
elevated
plus
maze
(EPM).
The
most
evident
impact
procedure
on
were
seen
FST
where
longer-duration
more
diverse
types
stressors
associated
smaller
size.
Next,
between
explore
these
might
measure
similar
or
different
consequences
found
positive
correlation
TST
FST,
OFT
EPM,
but
two
strongest
correlations
EPM
TST,
FST.
studies
deliberately
impose
suffering
over
long
periods,
our
data
raise
scientific
ethical
questions
around
them.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8189 - 8210
Опубликована: Авг. 1, 2024
Ferroptosis,
a
unique
form
of
regulated
cell
death
driven
by
iron-dependent
lethal
lipid
peroxidation,
is
implicated
in
various
stress-related
diseases
like
neurodegeneration,
vasculopathy,
and
metabolic
disturbance.
Stress-related
encompass
widespread
medical
disorders
that
are
influenced
or
exacerbated
stress.
These
stressors
can
manifest
organ
tissue
systems
have
significant
implications
for
human
overall
health.
Understanding
ferroptosis
these
offers
insights
therapeutic
strategies
targeting
relevant
pathways.
This
review
explores
mechanisms,
its
role
pathophysiology,
connection
to
diseases,
the
potential
ferroptosis-targeted
nanomedicines
treating
conditions.
monograph
also
delves
into
engineering
tackling
including
cancer,
cardia-cerebrovascular,
neurodegenerative,
inflammatory
diseases.
Anyhow,
nanotherapy
holds
promise
both
promoting
suppressing
managing
Current Cancer Drug Targets,
Год журнала:
2024,
Номер
24(11), С. 1089 - 1103
Опубликована: Янв. 29, 2024
Chronic
inflammation
is
associated
with
a
prolonged
increase
in
various
inflammatory
factors.
According
to
clinical
data,
it
can
be
linked
both
cancer
and
autoimmune
diseases
the
same
patients.
This
raises
critical
question
of
how
chronic
relates
seemingly
opposing
-
tumors,
which
there
immunosuppression,
diseases,
over-activation
immune
system.
In
this
review,
we
consider
as
prerequisite
for
suppression
an
increased
likelihood
damage.
We
also
discuss
potential
disease-modifying
therapies
targeting
inflammation,
helpful
autoimmunity.
On
one
hand,
pro-inflammatory
factors
persisting
areas
stimulate
production
anti-inflammatory
due
negative
feedback
loop,
eliciting
suppression.
other
bring
baseline
immunity
closer
threshold
level
required
triggering
response
using
bystander
activation
cells.
Focusing
on
role
may
open
prospects
more
intensive
drug
discovery
inflammation.
Cells,
Год журнала:
2024,
Номер
13(22), С. 1906 - 1906
Опубликована: Ноя. 18, 2024
Inflammation
is
an
essential
biological
process
that
serves
as
the
body's
first
line
of
defence
against
harmful
stimuli,
including
pathogens,
damaged
cells,
and
irritants
[...].
