Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(32), С. 17964 - 17976

Опубликована: Авг. 3, 2024

Spinal cord injury (SCI) is one of the most serious health problems, with no effective therapy. Recent studies indicate that Fisetin, a natural polyphenolic flavonoid, exhibits multiple functions, such as life-prolonging, antioxidant, antitumor, and neuroprotection. However, restorative effects Fisetin on SCI underlying mechanism are still unclear. In present study, we found reduced LPS-induced apoptosis oxidative damage in PC12 cells reversed M1 polarization BV2 cells. Additionally, safely effectively promoted motor function recovery mice by attenuating neurological promoting neurogenesis at lesion. Moreover, administration inhibited glial scar formation, modulated microglia/macrophage polarization, neuroinflammation. Network pharmacology, RNA-seq, molecular biology revealed activation JAK2/STAT3 signaling pathway. Notably, Colivelin TFA, an activator signaling, attenuated Fis-mediated neuroinflammation inhibition therapeutic mice. Collectively, promotes functional after inhibiting Thus, may be promising drug for treatment SCI.

Язык: Английский

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Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer

Journal of Complementary and Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract Fisetin, a flavonol belonging to the flavonoid subclass, is ubiquitous dietary present in fruits and vegetables, including fruit peels, has proven potential for anticancer activity, especially lung cancer – leading cause of cancer-related deaths globally. The current paper provides most detailed elaborate list various roles fisetin experimentally induced cells, these include promotion apoptosis, inhibition cell proliferation, migration, invasion, as well regulation autophagy. Among molecular targets, some identified pathways, such PI3K/Akt, MAPK, NF-κB, that affects are crucial tumor formation, so it can be considered chemopreventive agent. Moreover, improves effectiveness conventional treatments chemo- radiosensitizer minimizes side effects. However, overall utility clinical use now somewhat restricted by its poor solubility short half-life. It predicted future development nanotechnologies drug delivery, nanoparticle encapsulation, might help solve difficulties. Further Preclinical investigations required uniformly determine safety, efficacy, standard dosage consumption therapy.

Язык: Английский

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Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Язык: Английский

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Flavonoids in the regulation of microglial-mediated neuroinflammation; focus on fisetin, rutin, and quercetin

Experimental Cell Research, Год журнала: 2025, Номер unknown, С. 114537 - 114537

Опубликована: Март 1, 2025

Язык: Английский

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Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Язык: Английский

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Covalent inhibitors possessing autophagy-modulating capabilities: charting novel avenues in drug design and discovery

Drug Discovery Today, Год журнала: 2025, Номер unknown, С. 104347 - 104347

Опубликована: Апрель 1, 2025

Язык: Английский

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