Saudi Journal of Biological Sciences,
Год журнала:
2022,
Номер
30(2), С. 103523 - 103523
Опубликована: Дек. 5, 2022
Biofilm
could
be
defined
as
a
complex
communities
of
microorganisms
seen
affixed
to
surfaces,
they
form
clusters
without
sticking
any
surface
and
buried
firmly
in
an
extracellular
matrix
(ECM).
This
is
formed
by
the
formation
either
polymeric
substances
(EPSS)
or
polymer.
Many
reviews
have
addressed
negative
consequences
biofilm
production
food
industry,
among
which
we
talk
about
biofilms
being
responsible
for
spoilage
foodborne
pathogens
such
Listeria
monocytogenes,
Bacillus
cereus
etc.
These
contamination
linked
presence
processing
plant.
Although
researches
tried
conferring
solutions
these
challenges
however,
this
review
focus
on
positive
impact
industry.
It
critically
expedient
while
trying
find
solution
industry
develop
give
major
advantages
has
been
greatly
neglected.
Hence
article,
highlighted
some
impacts
like
enhancing
plant
health
productivity
products,
agent
water
wastewater
treatment
tool
reducing
amount
excess
sludge
The
development
edible
biofilms,
fermented
products
biodegradable
packaging
are
also
part
beneficial
roles
industries.
Antibiotics,
Год журнала:
2023,
Номер
12(2), С. 328 - 328
Опубликована: Фев. 4, 2023
Most
bacteria
attach
to
biotic
or
abiotic
surfaces
and
are
embedded
in
a
complex
matrix
which
is
known
as
biofilm.
Biofilm
formation
especially
worrisome
clinical
settings
it
hinders
the
treatment
of
infections
with
antibiotics
due
facilitated
acquisition
antibiotic
resistance
genes
(ARGs).
Environmental
now
considered
pivotal
for
driving
biofilm
formation,
biofilm-mediated
development
dissemination.
Several
studies
have
demonstrated
that
environmental
biofilms
can
be
hotspots
dissemination
ARGs.
These
encoded
on
mobile
genetic
elements
(MGEs)
such
conjugative
mobilizable
plasmids
integrative
(ICEs).
ARGs
rapidly
transferred
through
horizontal
gene
transfer
(HGT)
has
been
shown
occur
more
frequently
than
planktonic
cultures.
models
promising
tools
mimic
natural
study
via
HGT.
This
review
summarizes
state-of-the-art
techniques
visualize
three
main
HGT
mechanisms
biofilms:
transformation,
transduction,
conjugation.
Abstract
Bacterial
biofilm‐related
infectious
diseases
severely
influence
human
health.
Under
typical
situations,
pathogens
can
colonize
inert
or
biological
surfaces
and
form
biofilms.
Biofilms
are
functional
aggregates
that
coat
bacteria
with
extracellular
polymeric
substances
(EPS).
The
main
reason
for
the
failure
of
biofilm
infection
treatment
is
low
permeability
enrichment
therapeutic
agents
within
biofilm,
which
results
from
particular
features
matrix
barriers
such
as
negatively
charged
components
highly
viscous
compact
EPS
structures.
Hence,
developing
novel
strategies
enhanced
penetrability
crucial.
Herein,
current
progress
nanotechnology
methods
to
improve
agents’
against
matrix,
regulating
material
morphology
surface
properties,
utilizing
physical
penetration
nano/micromotors
microneedle
patches,
equipping
nanoparticles
degradation
enzymes
signal
molecules,
first
summarized.
Finally,
challenges,
perspectives,
future
implementations
engineered
delivery
systems
manage
infections
presented
in
detail.
Due
to
the
continuous
rise
in
biofilm-related
infections,
biofilms
seriously
threaten
human
health.
The
formation
of
makes
conventional
antibiotics
ineffective
and
dampens
immune
clearance.
Therefore,
it
is
important
understand
mechanisms
biofilm
develop
novel
strategies
treat
more
effectively.
This
review
article
begins
with
an
introduction
various
clinical
scenarios
their
corresponding
therapy.
Established
models
used
research
are
then
summarized.
potential
targets
which
may
assist
development
new
for
combating
further
discussed.
technologies
developed
recently
prevention
treatment
including
antimicrobial
surface
coatings,
physical
removal
biofilms,
molecules,
delivery
agents
subsequently
presented.
Finally,
directions
future
studies
pointed
out.
Pathogens,
Год журнала:
2024,
Номер
13(5), С. 393 - 393
Опубликована: Май 8, 2024
Medical
devices
such
as
venous
catheters
(VCs)
and
urinary
(UCs)
are
widely
used
in
the
hospital
setting.
However,
implantation
of
these
is
often
accompanied
by
complications.
About
60
to
70%
nosocomial
infections
(NIs)
linked
biofilms.
The
main
complication
ability
microorganisms
adhere
surfaces
form
biofilms
which
protect
them
help
persist
host.
Indeed,
crossing
skin
barrier,
insertion
VC
inevitably
allows
flora
or
accidental
environmental
contaminants
access
underlying
tissues
cause
fatal
complications
like
bloodstream
(BSIs).
In
fact,
80,000
central
catheters-BSIs
(CVC-BSIs)-mainly
occur
intensive
care
units
(ICUs)
with
a
death
rate
12
25%.
Similarly,
catheter-associated
tract
(CA-UTIs)
most
commonlyhospital-acquired
(HAIs)
worldwide.These
represent
up
40%
NIs.In
this
review,
we
present
summary
biofilm
formation
steps.
We
provide
an
overview
two
important
clinical
settings
medical
devices,
namely
catheter-asociated
(CA-BSIs)
(CA-UTIs),
highlight
also
multidrug
resistant
bacteria
implicated
infections.
Furthermore,
draw
attention
toseveral
useful
prevention
strategies,
advanced
antimicrobial
antifouling
approaches
developed
reduce
bacterial
colonization
on
catheter
incidence
catheter-related
Abstract
Biofilm‐associated
infections
are
one
of
the
most
challenging
healthcare
threats
for
humans,
accounting
80%
bacterial
infections,
leading
to
persistent
and
chronic
infections.
The
conventional
antibiotics
still
face
their
dilemma
poor
therapeutic
effects
due
high
tolerance
resistance
led
by
biofilm
barriers.
Nanotechnology‐based
antimicrobials,
nanoparticles
(NPs),
paid
attention
extensively
considered
as
promising
alternative.
This
review
focuses
on
whole
journey
NPs
against
biofilm‐associated
clarify
it
clearly,
is
divided
into
four
processes
in
sequence
1)
Targeting
biofilms,
2)
Penetrating
barrier,
3)
Attaching
cells,
4)
Translocating
through
cell
envelope.
Through
outlining
compositions
properties
biofilms
bacteria
recent
advances
present
strategies
each
process
comprehensively
discussed
combat
well
combined
these
with
drug
resistance,
aiming
guide
rational
design
facilitate
wide
application
Processes,
Год журнала:
2024,
Номер
12(2), С. 280 - 280
Опубликована: Янв. 27, 2024
A
biofilm
is
a
biologically
active
matrix
attached
to
the
surface
of
cells
and
their
extracellular
products.
As
they
are
mixture
many
microorganisms,
microbiological
activity
biofilms
varies
according
position
in
aggregate.
With
particular
emphasis
on
drinking
water
distribution
systems,
this
review
focuses
process
formation,
associated
bacteria,
chlorine
resistance
predominant
materials.
We
have
compiled
studies
bacteria
systems
interactions
with
formation
different
materials,
we
also
analysed
chlorine-resistant
problems
networks.
The
materials
used
network
significantly
affected
by
disinfection
method
produce
that
adheres
them.
Some
propose
material
inconsequential,
being
most
significant
factor.
Studies
suggest
based
plastics
(such
as
PVC
HDPE)
tend
be
more
effective
controlling
or
removal
than
those
metals
stainless
steel),
which
been
found
less
some
instances.
Chlorine-resistant
strains
becoming
common
networks,
resulting
occurrence
diseases
such
typhus
cholera.
Journal of Materials Research and Technology,
Год журнала:
2024,
Номер
31, С. 213 - 243
Опубликована: Июнь 12, 2024
Additive
manufacturing
(AM)
has
obtained
great
attentions
in
the
productions
of
customizable
implants
with
complex
shapes
and
good
mechanical
properties.
AM
fabricated
Ti
alloy
(Ti),
stainless
steel
(SS),
cobalt
chromium
(CoCr),
iron
(Fe)
have
been
revolutionized
medical
instruments,
such
as
artificial
organs,
including
heart
stents,
drug
delivery,
scaffolds
orthopedic
implants.
However,
high
Young's
modulus,
superior
characteristic,
lack
surface
integration,
corrosions,
failed
bone
remodeling,
antibacterial
performance
are
still
incomparable
to
be
used
anatomical
structure.
This
review
studied
issue
metallic
designed
by
powder
bed
fusion
selective
laser
melting
(SLM)
techniques
on
morphology,
stress
shielding
effects,
osseointegration,
capabilities
owing
implant
failure.
The
rate
degradation
corrosion
resistance
SLM
implant,
which
would
an
impact
cell
proliferation
remodeling
between
surrounding
tissue,
were
discussed.
current
article
also
highlighted
various
parameters,
like
mechanical,
chemical,
biological
modifications,
that
might
enhance
implant.
Finally,
applications,
challenges,
opportunities,
future
developments
using
addressed.
Journal of Applied Biomaterials & Functional Materials,
Год журнала:
2021,
Номер
19
Опубликована: Янв. 1, 2021
The
implants
are
increasingly
being
a
part
of
modern
medicine
in
various
surgical
procedures
for
functional
or
cosmetic
purposes.
progressive
use
is
associated
with
increased
infectious
complications
and
prevention
such
infections
always
remains
precedence
the
clinical
settings.
preventive
approaches
include
systemic
administration
antimicrobial
agents
before
after
as
well
local
application
antibiotics.
relevant
literature
existing
practices
have
highlighted
role
coating
infections,
although
applications
these
strategies
not
yet
standardized,
efficacy
much
clear.
adequate
data
from
randomized
control
trials
challenging
because
unavailability
large
sample
size
it
compulsory
this
context
to
assess
preemptive
practices.
This
review
compares
prospects
antimicrobial-coated
preventing
implant-related
infections.
