A Computational Framework for Understanding the Impact of Prior Experiences on Pain Perception and Neuropathic Pain DOI Creative Commons
Malin Ramne,

Jon Sensinger

PLoS Computational Biology, Год журнала: 2024, Номер 20(10), С. e1012097 - e1012097

Опубликована: Окт. 31, 2024

Pain perception is influenced not only by sensory input from afferent neurons but also cognitive factors such as prior expectations. It has been suggested that overly precise priors may be a key contributing factor to chronic pain states neuropathic pain. However, it remains an open question how in favor of might arise. Here, we first verify Bayesian approach can describe statistical integration expectations and results phenomena placebo hypoalgesia, nocebo hyperalgesia, pain, spontaneous Our indicate the value prior, which determined internal model parameters, contributor these phenomena. Next, apply hierarchical update parameters based on difference between predicted perceived reflect people integrate experiences their future In contrast with simpler approaches, this structure able show for hypoalgesia hyperalgesia arise form classical conditioning procedure. We demonstrate phenomenon offset analgesia, disproportionally large decrease obtained following minor reduction noxious stimulus intensity. Finally, turn simulations where our corroborates persistent non-neuropathic risk developing denervation, additionally offers interesting prediction complete absence informative painful could similar factor. Taken together, provide insight contribute perception, both experimental improving strategies prevention relief.

Язык: Английский

Peripherally acting anti-CGRP monoclonal antibodies alter cortical gray matter thickness in migraine patients: A prospective cohort study DOI Creative Commons
Edina Szabó, Sait Ashina,

Agustín Melo-Carrillo

и другие.

NeuroImage Clinical, Год журнала: 2023, Номер 40, С. 103531 - 103531

Опубликована: Янв. 1, 2023

Migraine is underpinned by central nervous system neuroplastic alterations thought to be caused the repetitive peripheral afferent barrage brain receives during headache phase (cortical hyperexcitability). Calcitonin gene-related peptide monoclonal antibodies (anti-CGRP-mAbs) are highly effective migraine preventative treatments. Their ability alter morphometry in treatment-responders vs. non-responders not well understood. Our aim was determine effects of anti-CGRP-mAb galcanezumab on cortical thickness after 3-month treatment patients with high-frequency episodic or chronic migraine. High-resolution magnetic resonance imaging performed pre- and post-treatment 36 patients. In this group, 19 were classified responders (≥50% reduction monthly days) 17 considered (<50% days). Following cross-sectional processing analyze baseline differences thickness, two-stage longitudinal symmetrized percent change conducted investigate treatment-related changes. At baseline, no significant found between non-responders. After treatment, decreased (compared baseline) observed regions somatosensory cortex, anterior cingulate medial frontal superior gyrus, supramarginal gyrus. Non-responders demonstrated left dorsomedial cortex We interpret thinning seen responder group as suggesting that head pain could lead changes neural swelling dendritic complexity such reflect recovery process from maladaptive activity. This conclusion further supported our recent study showing 3 months initiation, incidence premonitory symptoms prodromes followed decreases but themselves (that is, relates reductions nociceptive signals responders). speculate a much longer period required allow return more ‘normal’ functioning state whereby occur.

Язык: Английский

Процитировано

18

Hierarchical predictive coding in distributed pain circuits DOI Creative Commons
Zhe Chen

Frontiers in Neural Circuits, Год журнала: 2023, Номер 17

Опубликована: Март 3, 2023

Predictive coding is a computational theory on describing how the brain perceives and acts, which has been widely adopted in sensory processing motor control. Nociceptive pain involves large distributed network of circuits. However, it still unknown whether this completely decentralized or requires networkwide coordination. Multiple lines evidence from human animal studies have suggested that cingulate cortex insula (cingulate-insula network) are two major hubs mediating information afferents spinothalamic inputs, whereas subregions cortices distinct projections functional roles. In mini-review, we propose an updated hierarchical predictive framework for perception discuss its related computational, algorithmic, implementation issues. We suggest active inference as generalized algorithm, hierarchically organized traveling waves independent neural oscillations plausible mechanism to integrate bottom-up top-down across

Язык: Английский

Процитировано

13

Analgesia for the Bayesian Brain: How Predictive Coding Offers Insights Into the Subjectivity of Pain DOI Creative Commons
Friedrich Lersch, Fabienne Frickmann, Richard D. Urman

и другие.

Current Pain and Headache Reports, Год журнала: 2023, Номер 27(11), С. 631 - 638

Опубликована: Июль 8, 2023

Abstract Purpose of Review In order to better treat pain, we must understand its architecture and pathways. Many modulatory approaches pain management strategies are only poorly understood. This review aims provide a theoretical framework perception modulation in assist clinical understanding research analgesia anesthesia. Recent Findings Limitations traditional models for have driven the application new data analysis models. The Bayesian principle predictive coding has found increasing neuroscientific research, providing promising background principles consciousness perception. It can be applied subjective pain. Summary Pain viewed as continuous hierarchical process bottom-up sensory inputs colliding with top-down modulations prior experiences, involving multiple cortical subcortical hubs matrix. Predictive provides mathematical model this interplay.

Язык: Английский

Процитировано

11

Consciousness Research Through Pain DOI Open Access
Dong Ah Shin, Min Cheol Chang

Healthcare, Год журнала: 2025, Номер 13(3), С. 332 - 332

Опубликована: Фев. 6, 2025

Background/Objectives: Consciousness is a complex and elusive phenomenon encompassing self-awareness, sensory perception, emotions, cognition. Despite significant advances in neuroscience, understanding the neural mechanisms underlying consciousness remains challenging. Pain, as subjective multifaceted experience, offers unique lens for exploring by integrating inputs with emotional cognitive dimensions. This study examines relationship between pain, highlighting potential of pain model interplay experience activity. Methods: Literature review. Results: Key theories consciousness, such Global Workspace Theory Integrated Information Theory, provide diverse frameworks interpreting emergence consciousness. Similarly, research emphasizes role interpretation context shaping experiences, reflecting broader challenges studies. The limitations current methodologies, particularly difficulty objectively measuring phenomena, like are also addressed. highlights importance correlates, particular focus on brain regions, anterior cingulate cortex insula, which bridge experiences. By analyzing shared attributes this underscores to serve measurable proxy research. Conclusions: Ultimately, it contributes unraveling philosophical underpinnings offering implications mental health treatment advancements artificial intelligence. fills critical gap leveraging reproducible combining theoretical empirical evidence, novel insights into how emerges from processes.

Язык: Английский

Процитировано

0

Relationship of opioid tolerance to patient and wound factors, and wound micro-environment in patients with open wounds DOI
Jaewon Bae, Amy Campbell, Maria Hein

и другие.

Journal of Wound Care, Год журнала: 2025, Номер 34(Sup2), С. S6 - S16

Опубликована: Фев. 1, 2025

Objective: Opioid tolerance is a criterion for opioid use disorder, which currently an epidemic in the US. Individuals with open wounds are frequently administered opioids; however, phenomenon of has not been examined context wounds. The purpose this exploratory study was to compare patient/wound factors, wound microbiome and inflammatory mediators between individuals who were opioid-tolerant versus those opioid-tolerant. Method: Patients acute enrolled cross-sectional study. All data collected before during one-time dressing change. Results: included total 385 participants. Opioid-tolerant participants significantly younger (p<0.0001); had higher levels depression (p=0.0055) anxiety (p=0.0118); pain catastrophising scores (p=0.0035); reported resting number <30 days' duration (p=0.0486); lower bacterial richness (p=0.0152) than A backward elimination logistic regression model showed that four predictors—resting pain, age, depression—were most important variables predicting opioid-tolerance status. Conclusion: These findings provide first insights into This provides from guide hypothesis-driven research future.

Язык: Английский

Процитировано

0

Thermosensory predictive coding underpins an illusion of pain DOI Creative Commons
Jesper Fischer Ehmsen, Niia Nikolova,

Daniel Elmstrøm Christensen

и другие.

Science Advances, Год журнала: 2025, Номер 11(11)

Опубликована: Март 12, 2025

The human brain has a remarkable ability to learn and update its beliefs about the world. Here, we investigate how thermosensory learning shapes our subjective experience of temperature misperception pain in response harmless thermal stimuli. Through computational modeling, demonstrate that uses probabilistic predictive coding scheme changes based on their uncertainty. We find these expectations directly modulate perception grill illusion. Quantitative microstructural imaging further revealed individual variability parameters related uncertainty-driven decision-making is reflected microstructure regions such as precuneus, posterior cingulate gyrus, cerebellum, well basal ganglia brainstem. These findings provide framework understand infers from innocuous inputs, with important implications for etiology symptoms under chronic conditions.

Язык: Английский

Процитировано

0

Harnessing Extended Reality for Neurocognitive Training in Chronic Pain: State of the Art, Opportunities, and Future Directions DOI Open Access
Javier Guerra-Armas, Alberto Roldán‐Ruiz, Mar Flores-Cortés

и другие.

Healthcare, Год журнала: 2025, Номер 13(11), С. 1338 - 1338

Опубликована: Июнь 4, 2025

Chronic pain is a significant burden affecting more than 30% of people worldwide. Within the multiple biopsychosocial factors affected in suffering from chronic pain, neurocognitive impairments represent but often under-recognized aspect experience that impacts daily life and healthcare. Multiple domains, including attention, executive function, learning, memory, have been commonly associated with pain. novel approaches, extended reality (XR) has highlighted for its potential management. XR offers unique features to enhance traditional interventions, dual tasks, gamification, ecological validity, enriched experience, increase engagement motivation rehabilitation. This systematic–narrative hybrid literature review aims shed light on benefits, challenges, future directions technology address While preliminary evidence suggests XR-based training may be beneficial overcoming found some challenges still need addressed effective translation into clinical practice. transdiagnostic approach, appears valuable across different diagnoses wherein emerge as promising first-line intervention toward personalized multimodal management Despite rapid development substantial growing XR, enhanced methodological rigor reporting quality are recommended studies. More research needed fully understand mechanisms optimal application conditions.

Язык: Английский

Процитировано

0

Pain perception as hierarchical Bayesian inference: A test case for the theory of constructed emotion DOI Creative Commons
Arnaud Poublan‐Couzardot, Deborah Talmi

Annals of the New York Academy of Sciences, Год журнала: 2024, Номер 1536(1), С. 42 - 59

Опубликована: Июнь 1, 2024

Abstract An intriguing perspective about human emotion, the theory of constructed emotion considers emotions as generative models according to Bayesian brain hypothesis. This brings fresh insight existing findings, but its complexity renders it challenging test experimentally. We argue that laboratory studies pain could support because although some may not consider be a genuine must at minimum able explain perception and dysfunction in pathology. review emerging evidence bear on this question. cover behavioral neural computational models, placebo hyperalgesia, chronic pain. conclude there is substantial for predictive processing account painful experience, paving way better understanding neuronal mechanisms other emotions.

Язык: Английский

Процитировано

2

Expectation of pain and relief: A dynamical model of the neural basis for pain-trauma co-morbidity DOI
Irina A. Strigo,

A. D. Craig,

Alan N. Simmons

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 163, С. 105750 - 105750

Опубликована: Июнь 6, 2024

Язык: Английский

Процитировано

2

The Effect of Perioperative Auditory Stimulation with Music on Procedural Pain: A Narrative Review DOI Creative Commons

Fabienne C. S. Frickmann,

Richard D. Urman,

Kaya Siercks

и другие.

Current Pain and Headache Reports, Год журнала: 2023, Номер 27(8), С. 217 - 226

Опубликована: Июль 6, 2023

Music therapy has seen increasing applications in various medical fields over the last decades. In vast range of possibilities through which music can relieve suffering, there is a risk that-given its efficacy-the physiological underpinnings are too little understood. This review provides evidence-based neurobiological concepts for use perioperative pain management.The current neuroscientific literature shows significant convergence matrix and neuronal networks pleasure triggered by music. These functions seem to antagonize each other thus be brought fruition therapy. The encouraging results fMRI EEG studies still await full translation this top-down modulating mechanism into broad clinical practice. We embed framework. involves touching on Bayesian "predictive coding" theories strokes outlining functional units nociception matrix. will help understand findings summarized second part review. There opportunities practitioners, including anesthesiologists treating acute anxiety emergency situations, where could bring patients.

Язык: Английский

Процитировано

4