Current Opinion in Microbiology,
Год журнала:
2023,
Номер
76, С. 102381 - 102381
Опубликована: Сен. 11, 2023
Mammalian
microbiomes
have
coevolved
with
their
host
to
establish
a
stable
homeostatic
relationship.
Multifaceted
commensal-host
and
commensal–commensal
interactions
contribute
the
maintenance
of
equilibrium
an
impact
on
diverse
physiological
processes.
Despite
constant
exposure
physical
chemical
insults
from
environment,
skin
harbors
surprisingly
microbiome.
The
fungal
compartment
microbiome,
mycobiome,
is
unique
in
that
it
dominated
by
single
fungus,
Malassezia.
lack
diversity
suggests
may
provide
niche
for
this
genus
Malassezia
efficiently
outcompete
other
fungi
skin.
This
opinion
article
examines
aspects
support
hypothesis,
discusses
how
changes
conditions
associate
mycobiome
dysregulation,
highlights
emerging
example
being
displaced
pathogen
C.
auris,
thereby
generating
predisposing
situation
fatal-invasive
infection.
Cell Reports Medicine,
Год журнала:
2024,
Номер
5(7), С. 101621 - 101621
Опубликована: Июнь 20, 2024
Immune
checkpoint
inhibitors
(ICIs)
activate
anti-cancer
immunity
by
blocking
T
cell
molecules
such
as
programmed
death
1
(PD-1)
and
cytotoxic
lymphocyte-associated
protein
4
(CTLA-4).
Although
ICIs
induce
some
durable
responses
in
various
cancer
patients,
they
also
have
disadvantages,
including
low
response
rates,
the
potential
for
severe
side
effects,
high
treatment
costs.
Therefore,
selection
of
patients
who
can
benefit
from
ICI
is
critical,
identification
biomarkers
essential
to
improve
efficiency
ICIs.
In
this
review,
we
provide
updated
information
on
established
predictive
(tumor
death-ligand
[PD-L1]
expression,
DNA
mismatch
repair
deficiency,
microsatellite
instability
high,
tumor
mutational
burden)
currently
under
investigation
tumor-infiltrated
peripheral
lymphocytes,
gut
microbiome,
signaling
pathways
related
damage
antigen
presentation.
particular,
review
aims
summarize
current
knowledge
biomarkers,
discuss
issues,
further
explore
future
biomarkers.
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
14(2), С. 217 - 217
Опубликована: Фев. 18, 2024
Infectious
diseases
have
long
posed
a
significant
threat
to
global
health
and
require
constant
innovation
in
treatment
approaches.
However,
recent
groundbreaking
research
has
shed
light
on
previously
overlooked
player
the
pathogenesis
of
disease-the
human
microbiome.
This
review
article
addresses
intricate
relationship
between
microbiome
infectious
unravels
its
role
as
crucial
mediator
host-pathogen
interactions.
We
explore
remarkable
potential
harnessing
this
dynamic
ecosystem
develop
innovative
strategies
that
could
revolutionize
management
diseases.
By
exploring
latest
advances
emerging
trends,
aims
provide
new
perspective
combating
by
targeting
Biomedicines,
Год журнала:
2024,
Номер
12(5), С. 1023 - 1023
Опубликована: Май 7, 2024
The
synergic
role
of
vitamin
D
and
the
intestinal
microbiota
in
regulation
immune
system
has
been
thoroughly
described
literature.
Vitamin
deficiency
dysbiosis
have
shown
a
pathogenetic
development
numerous
immune-mediated
allergic
diseases.
physiological
processes
underlying
aging
sex
proven
to
be
capable
having
negative
influence
both
on
values
biodiversity
microbiome.
This
leads
global
increase
levels
systemic
inflammatory
markers,
with
potential
implications
for
all
diseases
conditions.
Our
review
aims
collect
analyze
relationship
between
microbiome
associated
it,
emphasizing
effect
mediated
by
sexual
hormones
aging.
Advanced Gut & Microbiome Research,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
The
microbiome,
a
diverse
ecosystem
of
microorganisms
within
the
human
body,
interacts
intricately
with
immune
system
to
maintain
health
and
prevent
disease.
This
dynamic
partnership
influences
development,
inflammation
regulation,
metabolic
health,
neurological
well‐being,
while
disruptions,
termed
dysbiosis,
have
been
linked
autoimmune
disorders,
chronic
diseases,
mental
issues.
review
highlights
microbiome’s
role
in
educating
system,
modulating
responses,
supporting
physical
barriers,
addressing
key
research
advances,
such
as
microbial
metabolites
regulation
impact
on
cancer
immunotherapy.
Emerging
technologies
like
multiomics
machine
learning
propelled
microbiome
research,
unlocking
potential
for
personalized
medicine
microbiome‐targeted
therapies.
Despite
progress,
challenges
remain
understanding
diversity,
individual
variability,
causation–correlation
microbiome–immune
interactions.
Future
directions
include
precision
medicine,
engineering,
public
interventions,
interdisciplinary
collaborations,
positioning
symbiosis
transformative
frontier
healthcare
innovation.
Abstract
Aging
is
associated
with
low‐grade
inflammation
that
increases
the
risk
of
infection
and
disease,
yet
underlying
mechanisms
remain
unclear.
Gut
microbiota
composition
shifts
age,
harboring
microbes
varied
immunogenic
capacities.
We
hypothesized
gut
acts
as
an
active
driver
during
aging.
Microbiome
patterns
in
aged
mice
strongly
signs
bacterial‐induced
barrier
disruption
immune
infiltration,
including
marked
increased
levels
circulating
lipopolysaccharide
(LPS)‐binding
protein
(LBP)
colonic
calprotectin.
Ex
vivo
immunogenicity
assays
revealed
both
contents
mucosa
harbored
capacity
to
activate
toll‐like
receptor
4
(TLR4)
whereas
TLR5
signaling
was
unchanged.
found
elevated
innate
inflammatory
(colonic
Il6
,
Tnf
Tlr4
)
endotoxemia
(circulating
LBP)
young
germ‐free
after
weeks
colonization
intestinal
from
compared
counterparts,
thus
providing
a
direct
link
between
aging‐induced
host
inflammation.
Additionally,
we
discovered
exhibited
unique
responses
broad‐spectrum
antibiotic
challenge
(Abx),
sustained
elevation
Escherichia
(Proteobacteria)
altered
7
days
post‐Abx
cessation.
Together,
these
data
indicate
old
age
results
differentially
on
TLR
pathways
system.
age‐associated
signatures
are
less
resilient
linked
status.
should
be
considered
critical
factors
mediating
chronic
diseases
disproportionally
impacting
older
populations.
Microorganisms,
Год журнала:
2023,
Номер
11(9), С. 2307 - 2307
Опубликована: Сен. 13, 2023
Recent
advances
in
metagenomic
analyses
have
made
it
easier
to
analyze
microbiota.
The
microbiota,
a
symbiotic
community
of
microorganisms
including
bacteria,
archaea,
fungi,
and
viruses
within
specific
environment
tissues
such
as
the
digestive
tract
skin,
has
complex
relationship
with
host.
studies
revealed
that
microbiota
composition
balance
particularly
affect
health
host
onset
disease.
Influences
diet,
food
preferences,
sanitation
play
crucial
roles
composition.
oral
cavity
is
where
directly
communicates
outside.
Stable
temperature
humidity
provide
optimal
growth
environments
for
many
bacteria.
However,
unique
susceptible
pH
changes,
salinity,
nutrients,
external
pathogens.
emphasized
importance
changes
bacterial
could
contribute
development
systemic
diseases.
This
review
focuses
on
saliva,
IgA,
fermented
foods
because
they
critical
maintaining
by
regulating
its
balance.
More
attention
should
be
paid
regulatory
factors
health.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(43), С. 23422 - 23426
Опубликована: Окт. 23, 2023
An
systematic
phenotypic
screen
of
the
mouse
gut
microbiome
for
metabolites
with
an
immunomodulatory
effect
identified
Muribaculum
intestinale
as
one
only
two
members
oversized
on
T-cell
populations.
Here
we
report
identification
and
characterization
a
lipid,
MiCL-1,
responsible
metabolite.
MiCL-1
is
18:1-16:0
cardiolipin,
whose
close
relatives
are
found
concave
lipid
surfaces
both
mammals
bacteria.
was
synthesized
to
confirm
structural
analysis
functionally
characterized
in
cell-based
assays.
It
has
highly
restrictive
structure–activity
profile,
its
chain-switched
analog
fails
induce
responses
any
our
robustly
induces
production
pro-inflammatory
cytokines
like
TNF-α,
IL-6,
IL-23,
but
no
detectable
anti-inflammatory
cytokine
IL-10.
As
case
other
recently
discovered
lipids,
requires
functional
TLR2
TLR1
not
TLR6
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Март 18, 2024
Driven
by
the
good
developmental
potential
and
favorable
environment
at
this
stage,
Ganoderma
lucidum
is
recognized
as
a
precious
large
fungus
with
medicinal
nutritional
health
care
values.
Among
them,
polysaccharides,
triterpenoids,
oligosaccharides,
trace
elements,
etc.
are
important
bioactive
components
in
G.
.
These
will
have
an
impact
on
gut
flora,
thus
alleviating
diseases
such
hyperglycemia,
hyperlipidemia
obesity
caused
flora
disorder.
While
numerous
studies
demonstrated
ability
of
its
active
to
regulate
systematic
review
mechanism
currently
lacking.
The
purpose
paper
summarize
regulatory
effects
cardiovascular,
gastrointestinal
renal
metabolic
diseases,
research
progress
improving
related
regulating
flora.
Additionally,
delves
into
principle
which
can
treat
or
assist
intestinal
tract
medicine,
food
clinical
application
were
fully
explored
for
researchers.
Immunological Reviews,
Год журнала:
2024,
Номер
325(1), С. 46 - 63
Опубликована: Май 16, 2024
Type
1
diabetes
(T1D)
is
a
chronic
autoimmune
disease
targeting
insulin-producing
pancreatic
beta
cells.
T1D
multifactorial
incorporating
genetic
and
environmental
factors.
In
recent
years,
the
advances
in
high-throughput
sequencing
have
allowed
researchers
to
elucidate
changes
gut
microbiota
taxonomy
functional
capacity
that
accompany
development.
An
increasing
number
of
studies
shown
role
mediating
immune
responses
health
disease,
including
autoimmunity.
Fecal
transplantations
(FMT)
been
largely
used
murine
models
prove
causal
microbiome
progression
be
safe
effective
treatment
inflammatory
human
diseases.
this
review,
we
summarize
discuss
research
regarding
microbiota-host
interactions
T1D,
current
advancement
therapies
for
usefulness
FMT
explore
immunity
encounters
shape
course
type
diabetes.
