Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 22, 2025

Physical exercise effectively prevents anxiety disorders caused by environmental stress. The neural circuitry mechanism, however, remains incomplete. Here, we identified a previously unrecognized pathway originating from the primary motor cortex (M1) to medial prefrontal (mPFC) via ventromedial thalamic (VM) nuclei in male mice. Besides anatomical evidence, both ex vivo and recordings showed enhanced excitability of M1-VM inputs prelimbic (PrL) region mPFC upon 14-day treadmill on chronic restraint stress (CRS) mouse model. Further functional interrogations demonstrated that activation this circuit is necessary sufficient direct anxiolytic effect training CRS Our findings provide more insights into circuits connecting mental regions under paradigm implicate potential targets for neuromodulation treating disorders. relieves disorders, while authors show input cortex, nuclei.

Язык: Английский

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The Impact of COVID-19 on Anxiety Disorders in Youth

Child and Adolescent Psychiatric Clinics of North America, Год журнала: 2023, Номер 32(3), С. 531 - 542

Опубликована: Фев. 3, 2023

Язык: Английский

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A systematic review and meta-analysis of neuroticism and anxiety during the COVID-19 pandemic

Frontiers in Psychiatry, Год журнала: 2024, Номер 14

Опубликована: Янв. 5, 2024

Introduction In response to the global impact of COVID-19 pandemic, concerns about mental health, particularly anxiety levels, have become prominent. This study aims explore relationship between neuroticism, a personality trait associated with emotional instability, and during outbreak. Methods A comprehensive literature search was conducted using Cochrane Library, HINARI, Google Scholar, PUBMED, resulting in identification 26 relevant papers. The protocol has been registered PROSPERO under number CRD42023452418. Thorough meta-analysis performed Comprehensive Meta-Analysis V4 software. Results Meta-analysis revealed significant positive studies supporting this association (OR = 3.213, 95% CI 2.352 4.391). findings underscore importance considering traits, understanding psychological responses major crises such as epidemic. Discussion observed connection neuroticism heightened levels emphasizes need for targeted interventions, especially individuals high neuroticism. Further research into potential therapeutic approaches mitigating consequences context catastrophe is warranted. Systematic Review Registration https://www.crd.york.ac.uk/prospero/#CRD42023452418 .

Язык: Английский

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Utilization of antidepressants, anxiolytics, and hypnotics during the COVID-19 pandemic

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 4, 2024

Abstract Since the onset of COVID-19 pandemic, there have been concerns over mental health impact COVID-19. This is a review utilization antidepressants, anxiolytics, and hypnotics since pandemic was declared on March 11th 2020. A number reports so far based large prescription databases for administrative use at national or regional level, but mainly in high-income countries. We found studies reporting increased rates during 2020, which has interpreted as hoarding such medications. In following months, most antidepressant did not display clear pattern change compared with prepandemic trends. later phases small increases higher than predicted rates, consistent finding, especially youth. countries, were increasing trends antidepressants also before needs to be considered when estimating whereas anxiolytics hypnotics, patterns prescriptions more varying. Overall, after 2020 we could find any distinct changes pandemic. Most contain information about prevalence indicated psychiatric disorders studied populations. More are needed long-term effects COVID-19, particularly regarding antidepressants. Research relating major depression anxiety would promote better understanding how well reflect population.

Язык: Английский

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Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: A monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 156, С. 113930 - 113930

Опубликована: Окт. 28, 2022

Depression is one of the most serious chronic psychiatric disorders affecting people worldwide. Subthreshold depression (SD) a form subclinical with increased risk major depressive disorder (MDD). Patients diagnosed SD may not be eligible for antidepressant drugs and, particularly in case MDD, these antidepressants have adverse effects which outweigh their therapeutic effects, leading to discontinuation therapy. Food supplements could provide an alternative strategy. The aim this study demonstrate efficacy food supplement based on combination S-adenosyl methionine (SAMe, 200 mg/day) and probiotics (Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175, 3 ×109 CFU/day) reducing symptoms monocentric, randomised, double-blind, placebo-controlled, cross-over clinical trial. 80 Subjects were recruited offered or placebo daily three months, according trial design, followed by six-week follow-up period. was measured means "Hamilton Rating Scale" (HAM-D) "Patient Health Questionnaire-9" (PHQ-9), using mixed analysis variance model, random intercept, statistical analysis. showed significant decrease PHQ-9 HAM-D scores resulting reduced MDD as compared placebo. In conclusion, intake SAMe probiotic strains period months effective improving quality life subjects who are therapies, patients suffering from mild-to-moderate sensitive cannot tolerate conventional drugs.

Язык: Английский

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Hepatology consultation is associated with decreased early return to alcohol use after discharge from an inpatient alcohol use disorder treatment program

Hepatology Communications, Год журнала: 2024, Номер 8(5)

Опубликована: Апрель 12, 2024

Background: Alcohol cessation is the only intervention that both prevents and halts progressions of alcohol-associated liver disease. The aim this study was to assess relationship between a return alcohol use consultation with hepatology in treatment-seeking patients disorder (AUD). Methods: Two hundred forty-two AUD were enrolled an inpatient treatment program, provided for 143 (59%) at request primary team. Patients not seen by served as controls. outcome any after discharge assessed using AUDIT-C 26 weeks discharge. Results: For endpoint, AUDIT week 26, 61% group 28% controls completed questionnaire ( p =0.07). secondary endpoint 52, these numbers 22% 11% = 0.6). At 39 (45%) versus 31 (70%) 0.006) returned use. evaluated had decreased rates hazardous compared controls, 36 (41%) 29 (66%) 0.008) patients, respectively, reporting There no significant differences baseline characteristics groups difference prescribing therapy. outcomes 52 weeks. Conclusions: significantly lower drinking but These findings suggest evaluation during may lead early

Язык: Английский

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Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 5, 2024

Abstract The major anxiety disorders (ANX; including generalized disorder, panic and phobias ) are highly prevalent, often onset early, persist throughout life, cause substantial global disability. Although distinct in their clinical presentations, they likely represent differential expressions of a dysregulated threat-response system. Here we present genome-wide association meta-analysis comprising 122,341 European ancestry ANX cases 729,881 controls. We identified 58 independent significant risk variants 66 genes with robust biological support. In an sample 1,175,012 self-report 1,956,379 controls, 51 the associated were replicated. As predicted by twin studies, found genetic correlation between depression, neuroticism, other internalizing phenotypes. Follow-up analyses demonstrated enrichment all brain regions highlighted GABAergic signaling as one potential mechanism underlying risk. These results advance our understanding architecture prioritize for functional follow-up studies.

Язык: Английский

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Investigating Best Practices for Ecological Momentary Assessment: Nationwide Factorial Experiment

Journal of Medical Internet Research, Год журнала: 2024, Номер 26, С. e50275 - e50275

Опубликована: Авг. 12, 2024

Background Ecological momentary assessment (EMA) is a measurement methodology that involves the repeated collection of real-time data on participants’ behavior and experience in their natural environment. While EMA allows researchers to gain valuable insights into dynamic behavioral processes, need for frequent self-reporting can be burdensome disruptive. Compliance with protocols important accurate, unbiased sampling; yet, there no “gold standard” study design promote compliance. Objective The purpose this was use factorial identify optimal factors, or combinations achieving highest completion rates smartphone-based EMAs. Methods Participants recruited from across United States were randomized 1 2 levels each 5 factors 2×2×2×2×2 (32 conditions): factor 1—number questions per survey (15 vs 25); 2—number EMAs day (2 4); 3—EMA prompting schedule (random fixed times); 4—payment type (US $1 paid payment based percentage completed); 5—EMA response scale (ie, slider-type Likert-type scale; only within-person factor; participant complete slider- first 14 days second period). All participants asked prompted 28 days. effect examined, as well effects interactions completion. Finally, relations between demographic socioenvironmental examined. Results (N=411) aged 48.4 (SD 12.1) years; 75.7% (311/411) female, 72.5% (298/411) White, 18.0% (74/411) Black African American, 2.7% (11/411) Asian, 1.5% (6/411) American Indian Alaska Native, 5.4% (22/411) belonged more than one race, 9.6% (38/396) Hispanic/Latino. On average, completed 83.8% (28,948/34,552) scheduled EMAs, 96.6% (397/411) follow-up survey. indicated significant main compliance interactions. Analyses also older adults, those without history substance problems, current depression tended counterparts. No other related rates. app liked system usability score=82.7), statistically positive association liking Conclusions Study results have broad implications developing best practices guidelines future studies methodologies. Trial Registration ClinicalTrials.gov number NCT05194228; https://clinicaltrials.gov/study/NCT05194228

Язык: Английский

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Association between non-carious cervical lesions, dentin hypersensitivity and anxiety in young adults: A cross-sectional study

Journal of Dentistry, Год журнала: 2025, Номер 153, С. 105563 - 105563

Опубликована: Янв. 8, 2025

Язык: Английский

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The concept of routine in nursing care: methodological reflections

Pielegniarstwo XXI wieku / Nursing in the 21st Century, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Introduction. Routine is a common concept in nursing practice, often perceived as repetitive yet essential for ensuring effi ciency and consistency care delivery. However, its role complex, balancing between providing structure hindering personalized care. Aim. This paper explores the of routine across multiple disciplines, including sociology, psychology, organizational studies, highlighting implications healthcare, nursing, research. Method. An overview literature. Conclusions. Given lack conceptual clarity routine, which may aff ect development recommendations on research are off ered. Key words: care, usual standard practice

Язык: Английский

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