Ginsenoside Re Prevents Depression-like Behaviors via Inhibition of Inflammation, Oxidative Stress, and Activating BDNF/TrkB/ERK/CREB Signaling: An In Vivo and In Vitro Study

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(36), С. 19838 - 19851

Опубликована: Авг. 26, 2024

Depression is a widespread disease, with high mortality and recurrence rates. Recent studies have shown that elevated cytokine levels are implicated in the molecular mechanisms of depression. Oxidative stress contributes to stimulation production. Growing evidence suggests ginsenoside Re (Gs-Re) exerts neuroprotective effect on hippocampus by suppressing oxidative inflammation. However, mechanism Gs-Re treatment depression remain understudied. This study aimed evaluate antidepressant-like effects possible underlying mechanisms. In this article, was studied both vitro (H

Язык: Английский

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Bidirectional associations between dietary diversity and depressive symptoms in Chinese adult women: A retrospective cohort study

Journal of Affective Disorders, Год журнала: 2024, Номер 351, С. 683 - 693

Опубликована: Фев. 3, 2024

Язык: Английский

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Assessment of Sugar-Related Dietary Patterns to Personality Traits and Cognitive–Behavioural and Emotional Functioning in Working-Age Women

Applied Sciences, Год журнала: 2024, Номер 14(8), С. 3176 - 3176

Опубликована: Апрель 10, 2024

This cross-sectional study investigated interactions among sugar-related dietary patterns (DPs), personality traits, and cognitive–behavioural emotional functioning. The involved working-age women aged 18–54. Data were collected between Winter Spring of 2020/21. survey was conducted using anonymised questionnaires. ten-item inventory (TIPI-PL) used to examine traits based on the Big Five trait model. A three-factor eating questionnaire (TFEQ-13) measure following behaviours: cognitive restraint (CR), uncontrolled (UE), (EE). KomPAN frequency intake. Dietary (DPs) derived by principal component analysis (PCA). logistic regression (OR) applied verify associations DPs, Three DPs identified: sweet-Western (SWDP), pro-healthy (PHDP), dairy (DDP). Women with high conscientiousness less likely, 33%, adhere upper tercile SWDP 80% more likely PHDP. Elevated CR intensity increased almost twofold (OR: 1.93; p < 0.001) likelihood adherence SWDP. in EE decreased 37% 0.63; 0.01) Personality behaviours significantly correlated extracted

Язык: Английский

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Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose–Response Meta-analysis of Epidemiologic Studies

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Май 29, 2024

Abstract Context The relation of magnesium (Mg) intake with depression was previously investigated by meta-analyses. However, due to limited data, a dose–response analysis not performed. Objective Considering the recently published articles, systematic review and meta-analysis conducted summarize dietary Mg in adults. Data Sources Medline (PubMed), ISI Web Science, Scopus, Google Scholar were comprehensively searched up August 2023. Extraction Observational studies that reported adults included their data extracted. Analysis A total 63 214 participants from 10 cross-sectional 3 cohort current study. Pooling 15 effect sizes 12 (including 50 275 participants) revealed individuals highest had 34% lower risk depression, compared those lowest (RR: 0.66; 95% CI: 0.57, 0.78). Moreover, linear each 100-mg/d increment associated 7% reduced 0.93; 0.90, 0.96). Additionally, based on nonlinear analysis, increasing 170 370 mg/d depression. Analyses also 9 (49 558 representative populations, similar results found 0.71; 0.61, 0.83) 0.96) analysis. Conclusion study shows an inverse dose–dependent association between intakes both general population manner. Systematic Review Registration PROSPERO registration no. CRD42024506570.

Язык: Английский

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Sex-based disparities in the association between uric acid levels and anxiety: a cross-sectional analysis of nationwide data in Korea

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 23, 2025

Abstract Background Uric acid has antioxidant properties, and several studies have suggested its neuroprotective effects. Despite reports of increased oxidative damage decreased antioxidants in anxiety disorders, findings remain inconclusive. This study investigated the association between serum uric levels symptoms, stratified by sex, using nationwide data from South Korea. Methods Data were derived Korea National Health Nutrition Examination Survey, which included 2,228 males 2,805 females. Presence symptoms was defined as a Generalized Anxiety Disorder 7-item scale (GAD-7) score ≥ 10. Study participants categorized into three groups based on levels: 1 (lowest) to 3 (highest). Multivariable logistic regression analyzed sex. Results Compared reference group 2, females had (odds ratio (OR) 2.28, 95% confidence interval (CI) 1.48–3.49). When GAD-7 5, (OR 1.68, CI 1.30–2.16) 1.35, 1.04–1.74) both showed more than with U-shaped relationship symptoms. In males, weren't significantly linked Conclusions indicates that low are associated higher prevalence only females, suggesting involvement stress disorders sex-based variation.

Язык: Английский

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PPARβ/δ Activation Improves Corticosterone‐Induced Oxidative Stress Damage in Astrocytes by Targeting UBR5/ATM Signaling

Journal of Neurochemistry, Год журнала: 2025, Номер 169(2)

Опубликована: Фев. 1, 2025

Oxidative stress-mediated astrocytic damage contributes to nerve injury and the development of depression, especially under stress conditions. Peroxisomes pexophagy are essential for balancing oxidative protein degradation products. Our previous findings suggest that peroxisome proliferators-activated receptor β/δ (PPARβ/δ) activation significantly alleviates depressive behaviors by preventing injury. However, underlying mechanisms remain unclear. In present study, we established treating astrocytes with corticosterone. Subsequently, PPARβ/δ agonists antagonists were applied determine effects on peroxisomes in astrocytes. The agonist (GW0742) improved cell viability decreased intracellular reactive oxygen species (ROS) production induced corticosterone, while pretreatment PPARβ/δ, antagonist GSK3787 reversed GW0742. Moreover, activating promoted peroxisomal biogenesis factor 5 (PEX5)-mediated enhancing phosphorylation ataxia-telangiectasia mutated (ATM) kinase. Conversely, blocking partially abolished Further investigations demonstrated not only transcription ubiquitin ligase E3 component n-recognin (UBR5) but also enhanced interaction between UBR5, contributing ATM interactor (ATMIN) degradation, increased phosphorylated kinase levels. Therefore, this study revealed improves corticosterone-induced pexophagy. directly interacts UBR5 facilitate ATMIN promotes phosphorylation, thereby maintaining balance These is a potential target promoting upon stress.

Язык: Английский

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Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y

European Journal of Nutrition, Год журнала: 2025, Номер 64(2)

Опубликована: Фев. 11, 2025

Язык: Английский

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Assessing oxidative, inflammatory and serotonergic pathways of coenzyme Q10 on anxiety and depression-like behavior caused by abstinence following co-administration of ethanol and nicotine in adolescent Wistar male rats

Heliyon, Год журнала: 2025, Номер unknown, С. e42752 - e42752

Опубликована: Фев. 1, 2025

Язык: Английский

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The brown alga Padina pavonica methanol and hexane partitions prevented depressive behavior induced by dexamethasone in mice

Research in Pharmaceutical Sciences, Год журнала: 2025, Номер 20(2), С. 241 - 249

Опубликована: Март 1, 2025

Background and purpose: Padina pavonica , a brown alga, displays protection against oxidative stress, neuroinflammation, neurodegenerative disorders. Considering the beneficial effects of P. since its antidepressant have not yet been studied, we investigated methanol hexane partitions (PMP PHP) in mice model. Experimental approach: In male (25 ± 2 g), depression was initiated by administrating dexamethasone (15 μg/kg) subcutaneously. PMP or PHP (80-160 mg/kg) administered intraperitoneally. All injections continued for two weeks. After locomotor test, different criteria were evaluated forced swim test (FST), marble burying (MBT), sucrose preference (SP) novelty-suppressed feeding (NSFT). Findings/Results: (160 showed effects, immobility time decreased significantly during FST (84.6 10.4 s) compared to control, food intake increased NSFT (21.1 2.5 mg/g) versus SP 81%. (80 reduced 124.5 6.7 s vehicle 85%. Dexamethasone-induced depression. While co-treatment with prevented dexamethasone. Only number buried marbles after 30 min control. The applied doses did cause significant changes activity. Conclusion implications: exhibited antidepressant-like mice. also marbles, implying reduction obsessive-like behavior. These observations underscore constituents inherent PHP, which merit further exploration elucidate their potential therapeutic applications.

Язык: Английский

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Early consumption of Stevia rebaudiana Bertoni on rat females: actions on their fertility, progeny and behavior

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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