The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 14, 2024

Abstract Context High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults is uncertain. Objective This study aimed synthesize findings on effects severity depressive symptoms depression. Data Sources PubMed, Cochrane CENTRAL, PsycINFO, Scopus, and Web Science were systematically searched from database inception March 2023. The Preferred Reporting Items for Systematic Review Meta-Analyses guidelines recommendations followed. We included randomized controlled trials (RCTs) comparing outcomes after control conditions disorders or symptoms. Extraction Two authors extracted data independently. Sidik-Jonkman estimator, I2 metric, prediction interval used estimate between-study heterogeneity. To determine bias certainty evidence RCTs, we Collaboration’s Risk Bias 2 Grades Recommendation, Assessment, Development, Evaluation tools, respectively. Analysis In total, 1507 participants (mean age range: 22.0 years–53.3 years) initially 5 RCTs this review. Compared conditions, significantly young middle-aged major mild moderate (standardized mean difference: –0.53; 95% confidence interval: –0.90 –0.16; = 87.1%). ranged –1.86 0.81. overall was within range “some concerns” “high,” while low. Conclusion appear have substantial potential alleviating people experiencing However, establish robust recommendations, there remains need high-quality, large-scale, long-term RCTs. Registration PROSPERO registration no. CRD42022341895.

Язык: Английский

---

Oral d-ribose causes depressive-like behavior by altering glycerophospholipid metabolism via the gut-brain axis

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Янв. 9, 2024

Abstract Our previous work has shown that d -ribose (RIB)-induced depressive-like behaviors in mice. However, the relationship between variations RIB levels and depression as well potential participation depressive disorder is yet unknown. Here, a reanalysis of metabonomics data from depressed patients model rats performed to clarify whether increased level positively correlated with severity depression. Moreover, we characterize intestinal epithelial barrier damage, gut microbial composition function, microbiota-gut-brain metabolic signatures RIB-fed mice using colonic histomorphology, 16 S rRNA gene sequencing, untargeted metabolomics analysis. The results show caused impairment axis dysbiosis. These modules are consistently enriched peripheral (fecal, colon wall, serum) central (hippocampus) glycerophospholipid metabolism. In addition, three differential genera (Lachnospiraceae_UCG-006, Turicibacter, Akkermansia) two types glycerophospholipids (phosphatidylcholine phosphatidylethanolamine) have greater contributions overall correlations glycerophospholipids. findings suggest disturbances microbiota by may contribute onset via regulating metabolism, providing new insight for understanding function

Язык: Английский

---

Effect of Different Dietary Patterns on Patients with Depressive Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients, Год журнала: 2025, Номер 17(3), С. 563 - 563

Опубликована: Янв. 31, 2025

Objectives: This study aimed to investigate the effects of different dietary patterns on depressive disorders. Methods: PubMed/MEDLINE, Cochrane CENTRAL, Embase, PsycINFO, Scopus, and ProQuest databases were systematically searched until 30 April 2024 for randomized controlled trials (RCTs) assessing symptoms in adults with Secondary outcomes included remission rates, quality life, safety. Standardized mean difference (SMD) 95% confidence intervals (CIs) aggregated using a random-effects model. Study was assessed Risk Bias (RoB)-2 tool, certainty evidence determined Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. Results: Five RCTs (n = 952) included, all investigating Mediterranean diet (MD) individuals major disorder or elevated depression levels. The analysis found no significant effect short-term MD intervention severity compared active (SMD −1.25 [95% CI: −5.11 2.61]) passive −0.22 −0.74 0.29]) controls. There life controls 0.71 CI −3.38 4.79]). Intermediate long-term results similar. overall risk bias “some concerns”, “very low” most results. Conclusions: appears have potential influence disorder. However, this finding should be interpreted cautiously due limited number RCTs. Further studies disorders are needed more robust conclusions. Systematic Review Registration: PROSPERO registration no. CRD42024541885.

Язык: Английский

---

Association between dietary patterns and suicide ideation among depressed adults: Insights from NHANES 2007–2020

Journal of Affective Disorders, Год журнала: 2025, Номер 377, С. 235 - 244

Опубликована: Фев. 21, 2025

Язык: Английский

---

The Economics of Treatment for Depression

Annual Review of Public Health, Год журнала: 2023, Номер 45(1), С. 527 - 551

Опубликована: Дек. 15, 2023

The global prevalence of depression has risen over the past three decades across all socioeconomic groups and geographic regions, with a particularly rapid increase in among adolescents (aged 12-17 years) United States. Depression imposes large health, economic, societal costs, including reduced life span quality life, medical educational attainment workplace productivity. A wide range treatment modalities for are available, but disparities access driven by lack culturally tailored options, stigma, provider shortages, other barriers. This review highlights need comparative research to better understand treatments' relative efficacy, cost-effectiveness, scalability, potential heterogeneity efficacy country cultural contexts. To address growing burden depression, mental health policy could consider reducing restrictions on supply providers, implementing digital interventions, promoting healthy lifestyles.

Язык: Английский

---

Association of composite dietary antioxidant index with depression and all-cause mortality in middle-aged and elderly population

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 29, 2024

Abstract Current research has shown an increasing acceptance of interventions for depression through dietary modifications. However, whether composite antioxidant index (CDAI) is associated with and all-cause mortality in middle-aged elderly population remains unknown. This study aimed to explore those associations American population. Weighted logistic regression models weighted Cox proportional hazard were used assess the association CDAI, covariates, depression, mortality, respectively. The stability results was also determined by a linear trend test based on CDAI quintiles. Restricted cubic spline curves employed non-linear relationships. In model adjusted all significant found ORs (95% CI) [0.77 (0.67, 0.89)] HRs mortality[0.91 (0.83, 1.00)]. Upon conducting restricted curves, we that between linear, whereas inflection point -0.19. Statistical significance only before point. this Americans, linearly negatively non-linearly mortality.

Язык: Английский

---

Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Advances in Nutrition, Год журнала: 2024, Номер 15(2), С. 100169 - 100169

Опубликована: Янв. 5, 2024

The risk of depression and anxiety is higher in people with metabolic conditions, but whether dietary approaches, which are central to the management can also improve uncertain. primary aim this systematic review meta-analysis was evaluate effects interventions on adults conditions. secondary hypocaloric isocaloric these outcomes. Four databases (MEDLINE, PsychINFO, EMBASE, CINAHL) were searched from inception March 2023. Randomized controlled trials (RCTs) including conditions (type 2 diabetes mellitus, hyperlipidemia, hypertension, and/or overweight/obesity) that assessed as outcomes included. Overall, 13 RCTs included review, ≤13 meta-analysis. Estimates pooled using random-effect for compared controls. Improvements scores found meta-analytic models all [pooled estimate standardized mean difference (SMD) = -0.20 (95% CI: -0.35, -0.05); P 0.007] only diets [SMD -0.27 -0.44, -0.10); 0.002]. There no improvements -0.14 -0.38, 0.10); 0.27]. In addition, there significant any scores. improved depression, not anxiety. These findings suggest play an important role This has been registered PROSPERO (CRD42021252307).

Язык: Английский

---

Mediterranean Diet and Mental Health in Children and Adolescents: A Systematic Review

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Май 17, 2024

Abstract Context Childhood and adolescence are periods of critical importance in the development mental health disorders. The Mediterranean diet (MD) has been linked to multiple positive outcomes, including reduced incidence disorders fewer psychiatric symptoms. Objective This study aimed investigate association between adherence an MD outcomes children adolescents. Methods A systematic literature review was conducted original research that explored relationship symptoms or MD. search on PubMed, Scopus, Web Science, MEDES, Dialnet, Latindex from inception November 2022, Newcastle-Ottawa Scale used evaluate quality studies. Results total 13 studies (6 cross-sectional, 4 case-control, 2 randomized clinical trials, 1 longitudinal cohort) out 450 met inclusion criteria. 3058 adolescents with a mean age range 8.6 16.2 years were included. Among reviewed studies, 5 (71.42%) those looking at attention-deficit/hyperactivity disorder, (80%) examining depression, (50%) assessing anxiety found significant protective association. Seven articles (53.84%) be high 6 (46.15%) moderate quality. Conclusion Adherence could factor for child adolescent populations. suggests promoting help prevent onset symptoms, reduce symptom severity, improve prognosis young patients. Systematic Review Registration PROSPERO registration no. CRD42021276316.

Язык: Английский

---

Ultra-Processed Foods and Mental Health: Where Do Eating Disorders Fit into the Puzzle?

Nutrients, Год журнала: 2024, Номер 16(12), С. 1955 - 1955

Опубликована: Июнь 19, 2024

Ultra-processed foods (UPFs) like pastries, packaged snacks, fast foods, and sweetened beverages have become dominant in the modern food supply are strongly associated with numerous public health concerns. While physical consequences of UPF intake been well documented (e.g., increased risks cardiometabolic conditions), less empirical discussion has emphasized mental chronic consumption. Notably, unique characteristics UPFs artificially high levels reinforcing ingredients) influence biological processes dopamine signaling) a manner that may contribute to poorer psychological functioning for some individuals. Importantly, gold-standard behavioral lifestyle interventions treatments specifically disordered eating do not acknowledge direct role play sensitizing reward-related neural functioning, disrupting metabolic responses, motivating subsequent cravings intake. The lack consideration influences on is particularly problematic given growing scientific support addictive properties these utility ultra-processed addiction (UPFA) as novel clinical phenotype endorsed by 14–20% individuals across international samples. overarching aim present review summarize science how affect health, emphasizing contributing mechanisms. Specifically, authors will (1) describe corporate-sponsored research financial agendas contributed contention debate about health; (2) define their nutritional characteristics; (3) observed associations between conditions, especially depression; (4) outline evidence UPFA; (5) nuanced treatment considerations comorbid UPFA disorders.

Язык: Английский

---

Association between the lean-to-fat mass ratio and depressive symptoms in adult Peruvian population: A cross-sectional analysis

Journal of Affective Disorders Reports, Год журнала: 2025, Номер unknown, С. 100868 - 100868

Опубликована: Янв. 1, 2025

Язык: Английский

---