Brain, Год журнала: 2023, Номер 146(12), С. 4916 - 4934
Опубликована: Окт. 18, 2023
Alzheimer's disease is a complex neurodegenerative disorder leading to decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor by showing specific alterations microbiome composition of patients rodent models. However, it unknown whether are causal manifestation symptoms. To understand involvement patient host physiology behaviour, we transplanted faecal from age-matched healthy controls into microbiota-depleted young adult rats. We found impairments behaviours reliant on hippocampal neurogenesis, essential process for certain memory functions mood, resulting transplants. Notably, severity correlated with clinical scores donor patients. Discrete changes rat caecal metabolome were also evident. As neurogenesis cannot be measured living humans but modulated circulatory systemic environment, assessed impact environment proxy readouts. Serum decreased human cells vitro associated key microbial genera. Our findings reveal first time, that symptoms can transferred organism via microbiota, confirming role disease, highlight converging central cellular regulating gut-mediated factors Alzheimer's.
Язык: Английский
Процитировано
114The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review
Nutrients, Год журнала: 2024, Номер 16(7), С. 1054 - 1054
Опубликована: Апрель 4, 2024
The microbiota-gut-brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health disease. Dysbiosis, disturbance in gut microbiome equilibrium, can significantly impact MGB axis, leading to alterations microbial composition function. Emerging evidence highlights connection between microbiota neurological psychiatric disorders, including depression. This review explores potential psychobiotics managing depressive emphasizing their role restoring balance axis. Psychobiotics exhibit positive effects on intestinal barrier, immune response, cortisol levels, hypothalamic-pituitary-adrenal (HPA) Studies suggest that probiotics may serve as an adjunct therapy for depression, especially treatment-resistant cases. discusses key findings from studies interventions, gut-brain mental health. increasing acceptance expanded concept underscores importance microorganisms well-being. As our understanding microbiome's disease grows, emerge promising agents addressing issues, providing new avenues therapeutic interventions disorders.
Язык: Английский
Процитировано
13Gut microbiome promotes mice recovery from stress-induced depression by rescuing hippocampal neurogenesis
Neurobiology of Disease, Год журнала: 2024, Номер 191, С. 106396 - 106396
Опубликована: Янв. 2, 2024
Studies from rodents to primates and humans indicate that individuals vary in how resilient they are stress, understanding the basis of these variations may help improve treatments for depression. Here we explored potential contribution gut microbiome such variation. Mice were exposed chronic unpredictable mild stress (CUMS) 4 weeks then allowed recover 3 weeks, after which subjected behavioral tests categorized as showing low or high resilience. The two types mouse compared terms hippocampal gene expression using RNA sequencing, fecal microbiomes 16S extent neurogenesis hippocampus immunostaining brain sections. Fecal microbiota transplanted either type into previously stress-exposed stress-naïve animals, effects transplantation on stress-induced behaviors examined. Finally, blocked temozolomide explore role promoted by enhancing resilience stress. Results showed highly stress-resilient mice, but not those with resilience, improved significantly measures anhedonia, despair, anxiety 3-week recovery CUMS. Their feces greater abundance Lactobacillus, Bifidobacterium Romboutsia than mice well lower Staphylococcus, Psychrobacter Corynebacterium. Similarly, animals Transplanting CUMS-exposed recipients rescued hippocampus, facilitating depression cognitive decline. Blockade abolished CUMS-induced decline In conclusion, our results suggested remodeling reverse impairment thereby promote
Язык: Английский
Процитировано
12Stress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions
Nature Mental Health, Год журнала: 2024, Номер 2(8), С. 935 - 950
Опубликована: Июнь 21, 2024
Язык: Английский
Процитировано
9Comparative Genomics of Pesticide-Degrading Enterococcus Symbionts of Spodoptera frugiperda (Lepidoptera: Noctuidae) Leads to the Identification of Two New Species and the Reappraisal of Insect-Associated Enterococcus Species
Microbial Ecology, Год журнала: 2023, Номер 86(4), С. 2583 - 2605
Опубликована: Июль 11, 2023
Язык: Английский
Процитировано
16A role of gut–brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress
Pharmacology Biochemistry and Behavior, Год журнала: 2024, Номер 238, С. 173736 - 173736
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
5Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review
Asian Journal of Psychiatry, Год журнала: 2023, Номер 91, С. 103861 - 103861
Опубликована: Дек. 13, 2023
Язык: Английский
Процитировано
12Gut–brain axis modulation by sudachi peel extract enhances resilience to chronic social defeat stress in mice
Journal of Affective Disorders, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice
Molecular Brain, Год журнала: 2024, Номер 17(1)
Опубликована: Ноя. 7, 2024
Chronic exposure to glucocorticoids in response long-term stress is thought be a risk factor for major depression. Depression associated with disturbances the gut microbiota composition and peripheral central energy metabolism. However, relationship between chronic glucocorticoid exposure, microbiota, brain metabolism remains largely unknown. In this study, we first investigated effects of corticosterone on various domains behavior adult male C57BL/6J mice treated evaluate them as an animal model We then examined microbial plasma metabolome corticosterone-treated mice. treatment resulted reduced locomotor activity, increased anxiety-like depression-related behaviors, decreased rotarod latency, acoustic startle response, social behavior, working memory deficits, impaired contextual fear memory, enhanced cued memory. also altered which has been reported depression, such abundance Bifidobacterium, Turicibacter, Corynebacterium Barnesiella. Metabolomic data revealed that led decrease neurotransmitter metabolites, serotonin, 5-hydroxyindoleacetic acid, acetylcholine, gamma-aminobutyric well changes betaine methionine metabolism, indicated by levels adenosine, dimethylglycine, choline, brain. These results indicate have good face construct validity studying anxiety depression offering new insights into neurobiological basis arising from gut-brain axis dysfunction caused prolonged excessive glucocorticoids.
Язык: Английский
Процитировано
3Genomics of insecticide-metabolizing bacteria associated with >i<Spodoptera frugiperda>/i< (Lepidoptera: Noctuidae) and their potential role in host detoxification
Опубликована: Фев. 7, 2024
Genomics of insecticide-metabolizing bacteria associated with Spodoptera frugiperda (Lepidoptera: Noctuidae)
Язык: Английский
Процитировано
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