Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 5, 2023
Abstract
Marine
resources
in
unique
marine
environments
provide
abundant,
cost-effective
natural
biomaterials
with
distinct
structures,
compositions,
and
biological
activities
compared
to
terrestrial
species.
These
marine-derived
raw
materials,
including
polysaccharides,
protein
components,
fatty
acids,
minerals,
etc.,
have
shown
great
potential
preparing,
stabilizing,
or
modifying
multifunctional
nano-/micro-systems
are
widely
applied
drug
delivery,
theragnostic,
tissue
engineering,
etc.
This
review
provides
a
comprehensive
summary
of
the
most
current
biomaterial-based
developed
over
past
three
years,
primarily
focusing
on
therapeutic
delivery
studies
highlighting
their
cure
variety
diseases.
Specifically,
we
first
provided
detailed
introduction
physicochemical
characteristics
biocomponents
state.
Furthermore,
assembly
processes,
functionalities
each
building
block,
thorough
evaluation
pharmacokinetics
pharmacodynamics
advanced
systems
effects
molecular
pathophysiological
processes
were
fully
elucidated.
Finally,
list
unresolved
issues
pivotal
challenges
applications,
such
as
standardized
distinction
long-term
biosafety
vivo,
feasibility
scale-up,
was
presented.
is
expected
serve
roadmap
for
fundamental
research
facilitate
rational
design
diverse
emerging
applications.
Graphical
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2022,
Номер
10
Опубликована: Авг. 5, 2022
As
an
emerging
fringe
science,
bionics
integrates
the
understanding
of
nature,
imitation
and
surpassing
nature
in
one
aspect,
it
organically
combines
synergistic
complementarity
function
structure–function
integrated
materials
which
is
great
scientific
interest.
By
imitating
microstructure
a
natural
biological
surface,
bionic
superhydrophobic
surface
prepared
by
human
beings
has
properties
self-cleaning,
anti-icing,
water
collection,
anti-corrosion
oil–water
separation,
preparation
research
methods
are
increasing.
The
include
vapor
deposition,
etching
modification,
sol–gel,
template,
electrostatic
spinning,
spraying,
can
be
applied
to
fields
such
as
medical
care,
military
industry,
ship
textile.
modification
method
directly
modify
substrate,
so
there
no
need
worry
about
adhesion
between
coating
substrate.
most
obvious
advantage
this
that
obtained
with
substrate
good
stability
corrosion
resistance.
In
article,
different
were
summarized,
especially
methods,
we
discussed
detailed
classification,
advantages,
disadvantages
these
future
development
direction
field
was
prospected.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Май 24, 2023
Introduction:
Reactive
oxygen
species
(ROS)-mediated
therapies
have
typically
been
considered
as
noninvasive
tumor
treatments
owing
to
their
high
selectivity
and
efficiency.
However,
the
harsh
microenvironment
severely
impairs
Methods:
Herein,
biodegradable
Cu-doped
zeolitic
imidazolate
framework-8
(ZIF-8)
was
synthesized
for
loading
photosensitizer
Chlorin
e6
(Ce6)
CaO2
nanoparticles,
followed
by
surface
decoration
hyaluronic
acid
(HA),
obtaining
HA/CaO2-Ce6@Cu-ZIF
nano
platform.
Results
Discussion:
Once
targets
sites,
degradation
of
Ce6
release
from
in
response
environment,
while
Cu2+
active
sites
on
Cu-ZIF
are
exposed.
The
released
decompose
generate
hydrogen
peroxide
(H2O2)
(O2),
which
alleviate
insufficiency
intracellular
H2O2
hypoxia
(TME),
effectively
enhancing
production
hydroxyl
radical
(•OH)
singlet
(1O2)
Cu2+-mediated
chemodynamic
therapy
(CDT)
Ce6-induced
photodynamic
(PDT),
respectively.
Importantly,
Ca2+
originating
could
further
enhance
oxidative
stress
result
mitochondrial
dysfunction
induced
overloading.
Conclusion:
Thus,
H2O2/O2
self-supplying
overloading
ZIF-based
nanoplatform
cascade-amplified
CDT/PDT
synergistic
strategy
is
promising
highly
efficient
anticancer
therapy.
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
Immune
cell-based
therapies
are
a
rapidly
emerging
class
of
new
medicines
that
directly
treat
and
prevent
targeted
cancer.
However
multiple
biological
barriers
impede
the
activity
live
immune
cells,
therefore
necessitate
use
surface-modified
cells
for
cancer
prevention.
Synthetic
and/or
natural
biomaterials
represent
leading
approach
cell
surface
modulation.
Different
types
can
be
applied
to
membranes
through
hydrophobic
insertion,
layer-by-layer
attachment,
covalent
conjugations
acquire
modification
in
mammalian
cells.
These
generate
reciprocity
enable
cell–cell
interactions.
In
this
review,
we
highlight
different
(lipidic
polymeric)-based
advanced
applications
cell–surface
modulation,
few
recognition
moieties,
how
their
interplay
interaction.
We
discuss
cancer-killing
efficacy
NK
followed
by
engineering
treatment.
Ultimately,
review
connects
biologically
active
play
key
roles
immunotherapy
applications.
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 2921 - 2949
Опубликована: Июль 1, 2024
Abstract:
Inflammatory
bowel
disease
(IBD)
is
a
chronic,
non-specific
inflammatory
condition
characterized
by
recurring
inflammation
of
the
intestinal
mucosa.
However,
existing
IBD
treatments
are
ineffective
and
have
serious
side
effects.
The
etiology
multifactorial
encompasses
immune,
genetic,
environmental,
dietary,
microbial
factors.
nanoparticles
(NPs)
developed
based
on
specific
targeting
methodologies
exhibit
great
potential
as
nanotechnology
advances.
Nanoparticles
defined
particles
between
1
100
nm
in
size.
Depending
their
size
surface
functionality,
NPs
different
properties.
A
variety
nanoparticle
types
been
employed
drug
carriers
for
treatment
(IBD),
with
encouraging
outcomes
observed
experimental
models.
They
increase
bioavailability
drugs
enable
targeted
delivery,
promoting
localized
thus
enhancing
efficacy.
Nevertheless,
numerous
challenges
persist
translation
from
nanomedicine
to
clinical
application,
including
enhanced
formulations
preparation
techniques,
safety
profiles,
so
forth.
In
future,
it
will
be
necessary
scientists
clinicians
collaborate
order
study
mechanisms,
develop
new
delivery
strategies,
screen
nanomedicines.
Keywords:
nanoparticles,
diseases,
passive
targeting,
active
system
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 5, 2023
Abstract
Marine
resources
in
unique
marine
environments
provide
abundant,
cost-effective
natural
biomaterials
with
distinct
structures,
compositions,
and
biological
activities
compared
to
terrestrial
species.
These
marine-derived
raw
materials,
including
polysaccharides,
protein
components,
fatty
acids,
minerals,
etc.,
have
shown
great
potential
preparing,
stabilizing,
or
modifying
multifunctional
nano-/micro-systems
are
widely
applied
drug
delivery,
theragnostic,
tissue
engineering,
etc.
This
review
provides
a
comprehensive
summary
of
the
most
current
biomaterial-based
developed
over
past
three
years,
primarily
focusing
on
therapeutic
delivery
studies
highlighting
their
cure
variety
diseases.
Specifically,
we
first
provided
detailed
introduction
physicochemical
characteristics
biocomponents
state.
Furthermore,
assembly
processes,
functionalities
each
building
block,
thorough
evaluation
pharmacokinetics
pharmacodynamics
advanced
systems
effects
molecular
pathophysiological
processes
were
fully
elucidated.
Finally,
list
unresolved
issues
pivotal
challenges
applications,
such
as
standardized
distinction
long-term
biosafety
vivo,
feasibility
scale-up,
was
presented.
is
expected
serve
roadmap
for
fundamental
research
facilitate
rational
design
diverse
emerging
applications.
Graphical
