Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

Small Methods, Год журнала: 2023, Номер 8(3)

Опубликована: Ноя. 23, 2023

Abstract Zeolite imidazole framework‐8 (ZIF‐8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability structural regularity, ZIF‐8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, development recent progress various approaches briefly summarized. addition, interesting properties adjustable porosity, excellent thermal, chemical stabilities introduced. Further, five representative biomedical highlighted based on above physicochemical properties. Finally, remaining challenges offered insights into future outlook also discussed. This review aims understand co‐relationships between structures offering opportunity construct attractive materials promising characteristics.

Язык: Английский

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Metal–Organic Framework Nanocomposites in Conquering Hypoxia for Tumor Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(17)

Опубликована: Янв. 3, 2024

Abstract Hypoxia, as a distinctive feature of tumors, is closely related to tumor recurrence, metastasis, and treatment resistance. Metal–organic framework (MOF) exhibits an increasing number advantages in cancer therapy owing its porous structure, large specific surface area, tunable function. The MOF nanocomposites constructed by adjusting components can effectively overcome hypoxia significantly enhance the anti‐tumor effect. In this review, hypoxic characteristics tumors current strategies for constructing that are summarized, including delivering O 2 or endogenously generating elevate intra‐tumor content; inhibiting HIF‐1 induced products alleviate hypoxia; reducing cellular aerobic respiration decrease consumption, exacerbating improve efficacy hypoxia‐activated pre‐drugs. At same time, applications applied different therapeutic methods at present stage described, finally, challenges opportunities further development discussed.

Язык: Английский

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Covalent organic frameworks-derived carbon nanospheres based nanoplatform for tumor specific synergistic therapy via oxidative stress amplification and calcium overload

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 661, С. 908 - 922

Опубликована: Фев. 5, 2024

Язык: Английский

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Designs of metal-organic framework nanoparticles for protein delivery

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 178 - 190

Опубликована: Авг. 4, 2023

Язык: Английский

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Application and prospect of Cu-based metal-organic frameworks in tumor therapy

Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 139984 - 139984

Опубликована: Сен. 11, 2024

Язык: Английский

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Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Янв. 29, 2025

Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at target site to catalyze production reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy PDT depends on PSs, amount oxygen, intensity excitation laser. PSs have been extensively researched, great efforts made develop an ideal photosensitizer. Chlorin-e6 is FDA-approved second-generation that has attracted widespread research interest medical field, especially with respect antitumor anti-inflammatory activity. possesses advantages a large absorption coefficient, high strength, low residue body, relatively safety thus promising application prospects. Here we review use chlorin-e6 discuss prospects further development this technology.

Язык: Английский

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Advances in Nanotherapeutics for Tumor Treatment by Targeting Calcium Overload

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114190 - 114190

Опубликована: Сен. 2, 2024

Язык: Английский

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A hyaluronic acid Schiff base @ hollow calcium peroxide @ copper carbon dots nanoconjugate enhances chemodynamic tumor therapy based on multiple approaches strategy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 311, С. 144039 - 144039

Опубликована: Май 9, 2025

Язык: Английский

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GSH-Triggered/Photothermal-Enhanced H2S Signaling Molecule Release for Gas Therapy

Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2443 - 2443

Опубликована: Окт. 10, 2023

Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic such as phototherapy, chemodynamic therapy, gasodynamic therapy been innovatively developed. High concentrations of hydrogen sulfide (H2S) gas exhibit cancer-suppressive Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced H2S signaling molecule release properties therapy. The as-synthesized nanoplatform confined PB nanoparticles in the structure silica due to electrostatic adsorption. In case GSH overexpressed tumor microenvironment, controllably released. And temperature increases photothermal effects nanoparticles, further enhancing release. same time, excellent peroxide catalytic performance also amplified efficiency Thus, collective therapy/photothermal therapy/catalytic functionalities shows potential promise terms efficient

Язык: Английский

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A Copper Silicate-Based Multifunctional Nanoplatform with Glutathione Depletion and Hypoxia Relief for Synergistic Photodynamic/Chemodynamic Therapy

Materials, Год журнала: 2024, Номер 17(14), С. 3495 - 3495

Опубликована: Июль 15, 2024

Chemodynamic therapy (CDT) alone cannot achieve sufficient therapeutic effects due to the excessive glutathione (GSH) and hypoxia in tumor microenvironment (TME). Developing a novel strategy improve efficiency is urgently needed. Herein, we prepared copper silicate nanoplatform (CSNP) derived from colloidal silica. The Cu(II) CSNP can be reduced Cu(I), which cascades induce subsequent CDT process. Additionally, benefiting GSH depletion oxygen (O

Язык: Английский

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