The immune landscape in apical periodontitis: From mechanism to therapy
International Endodontic Journal,
Год журнала:
2024,
Номер
57(11), С. 1526 - 1545
Опубликована: Авг. 1, 2024
Apical
periodontitis
(AP)
is
featured
by
a
persistent
inflammatory
response
and
alveolar
bone
resorption
initiated
microorganisms,
posing
risks
to
both
dental
systemic
health.
Nonsurgical
endodontic
treatment
the
recommended
plan
for
AP
with
high
success
rate,
but
in
some
cases,
periapical
lesions
may
persist
despite
standard
treatment.
Better
comprehension
of
microenvironment
can
help
develop
adjunct
therapies
improve
outcome
This
review
presents
an
overview
immune
landscape
AP,
elucidating
how
microbial
invasion
triggers
host
activation
shapes
microenvironment,
ultimately
impacting
homeostasis.
The
destructive
effect
excessive
on
tissues
emphasized.
aimed
systematically
discuss
immunological
basis
cell
network
thereby
providing
insights
into
potential
immunotherapeutic
strategies
such
as
targeted
therapy,
antioxidant
adoptive
therapy
cytokine
mitigate
AP-associated
tissue
destruction.
Язык: Английский
Causal effects of circulating inflammatory proteins on oral phenotypes: Deciphering immune-mediated profiles in the host-oral axis
International Immunopharmacology,
Год журнала:
2024,
Номер
144, С. 113642 - 113642
Опубликована: Ноя. 22, 2024
Язык: Английский
Yam Carbon Dots Promote Bone Defect Repair by Modulating Histone Demethylase 4B
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 10415 - 10434
Опубликована: Окт. 1, 2024
Chronic
apical
periodontitis
is
a
typical
inflammatory
disease
of
the
oral
cavity,
pathology
characterized
by
an
reaction
with
bone
defects
in
periapical
area.
Chinese
medicine
our
traditional
medicine,
Carbon
Dots
(CDs)
are
new
type
nanomaterials.
The
purpose
this
study
was
to
prepare
Yam
(YAM-CDs)
investigate
mechanism
action
YAM-CDs
on
differentiation
vivo
and
vitro.
Язык: Английский
Insulin-like growth factor binding protein 7 identified in aged dental pulp by single-cell RNA sequencing
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Aging
influences
the
regenerative
and
reparative
functions
of
dental
pulp,
an
in-depth
complete
understanding
aged
pulp
is
highly
important.
Язык: Английский
Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis
Oral Diseases,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 18, 2024
Abstract
Objectives
The
objectives
of
current
study
were
to
investigate
the
role
and
related
mechanism
Ginsenoside
Rb1
(GRb1)
on
regulating
apical
periodontitis
(AP)
prognosis.
Materials
Methods
Clinical
specimens
used
determine
involvement
calcium
overload‐induced
macrophage
pyroptosis
in
periapical
tissues.
Next,
a
ion‐chelating
agent
(BAPTA‐AM)
was
applied
detect
suppression
intracellular
overload
pyroptosis.
Then,
network
pharmacology,
western
blot
(WB)
analysis,
Fluo‐4
assay
conducted
explore
GRb1
overload.
To
gain
better
understanding
linked
AP,
GRb1‐treated
AP
models
established.
Results
We
discovered
clinically
experimentally
that
overload‐dependent
is
involved
pathogenesis,
reducing
greatly
decreased
an
cell
model.
based
GRb1's
inhibitory
aberrant
accumulation,
we
alleviates
by
suppressing
calcium‐dependent
both
vitro
vivo
models.
Conclusions
effective
therapeutic
strategy
rescue
tissues
from
inflammation
due
its
anti‐pyroptosis
function.
Thus,
present
supports
further
investigation
as
adjuvant
therapy
for
AP.
Язык: Английский