Pathogens,
Год журнала:
2023,
Номер
12(6), С. 766 - 766
Опубликована: Май 26, 2023
In
a
mutually
beneficial
connection
with
its
host,
the
gut
microbiota
affects
host's
nutrition,
immunity,
and
metabolism.
An
increasing
number
of
studies
have
shown
links
between
certain
types
disease
dysbiosis
or
specific
microorganisms.
Fecal
transplantation
(FMT)
is
strongly
advised
for
treatment
recurrent
resistant
Clostridium
difficile
infection
(CDI)
due
to
outstanding
clinical
effectiveness
against
CDI.
The
therapeutic
potential
FMT
other
disorders,
particularly
inflammatory
bowel
diseases
malignancies,
currently
gaining
more
attention.
We
summarized
most
recent
preclinical
evidence
show
promise
in
management
cancer
as
well
complications
related
after
reviewing
research
on
relationship
cancer.
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 616 - 616
Опубликована: Март 8, 2024
Autoimmune
diseases
are
complex
multifactorial
disorders,
and
a
mixture
of
genetic
environmental
factors
play
role
in
their
onset.
In
recent
years,
the
microbiota
has
gained
attention
as
it
helps
to
maintain
host
health
immune
homeostasis
is
relevant
player
interaction
between
our
body
outside
world.
Alterations
(dysbiosis)
its
composition
or
function
have
been
linked
different
pathologies,
including
autoimmune
diseases.
Among
functions,
there
activation/modulation
cells
that
can
protect
against
infections.
However,
if
dysbiosis
occurs,
compromise
host’s
ability
pathogens,
contributing
development
progression
some
cases,
infections
trigger
by
several
mechanisms,
alteration
gut
permeability
activation
innate
produce
pro-inflammatory
cytokines
recruit
autoreactive
T
B
cells.
this
scenario,
we
cannot
neglect
critical
hormones’
roles
regulating
responses.
Different
hormones,
especially
estrogens,
shown
influence
modulating
activity
system
ways.
review,
summarized
main
mechanisms
connection
infections,
microbiota,
immunity,
hormones
diseases’
onset
given
hormone
levels
on
pathogenesis.
detail,
focused
rheumatoid
arthritis,
multiple
sclerosis,
systemic
lupus
erythematosus.
Abstract
Noncanonical
pyroptosis
is
triggered
by
Caspase
4/5/11,
which
cleaves
Gasdermin
D
(GSDMD),
leading
to
cell
lysis.
While
GSDMD
has
been
studied
previously
in
systemic
lupus
erythematosus
(SLE),
the
role
of
SLE
pathogenesis
remains
unclear
and
contentious,
with
limited
understanding
11‐mediated
this
condition.
In
study,
we
explored
level
SLE,
identifying
both
upstream
pathways
interaction
between
adaptive
immune
responses.
We
observed
increased
5/11
GSDMD‐dependent
macrophages/monocytes
patients
mice.
identified
serum
lipopolysaccharide
(LPS),
released
from
gut
due
a
compromised
barrier,
as
signal
that
triggers
11
activation
MRL/lpr
further
discovered
pyroptotic
macrophages
promote
differentiation
mature
B
cells
independently
T
cells.
Additionally,
inhibiting
preventing
LPS
leakage
proved
effective
improving
symptoms
These
findings
suggest
elevated
LPS,
resulting
damaged
induces
11/GSDMD‐mediated
pyroptosis,
turn
promotes
enhances
autoimmune
responses
SLE.
Thus,
targeting
could
be
viable
therapeutic
strategy
for
Nutrients,
Год журнала:
2023,
Номер
15(15), С. 3359 - 3359
Опубликована: Июль 28, 2023
Numerous
interrelationships
are
known
in
the
literature
that
have
final
effect
of
unmasking
or
influencing
various
pathologies.
Among
these,
present
article
aims
to
discuss
connection
between
systemic
lupus
erythematosus
(SLE)
and
human
microbiome.
The
main
purpose
this
work
is
popularize
information
about
impact
dysbiosis
on
pathogenesis
evolutionary
course
pediatric
patients
with
SLE.
Added
interest
knowledge
awareness
adjunctive
therapeutic
means
has
ultimate
goal
increasing
quality
life.
by
which
can
be
achieved
briefly
divided
into
prophylactic
curative,
depending
phase
condition
patient
is.
We
thus
reiterate
importance
clinician
acquiring
an
overview
SLE
microbiome,
doubled
in-depth
physio-pathogenic
interactions
two
(in
part
through
much-studied
gut-target
organ
axes—brain,
heart,
lung,
skin),
target
objective
being
obtaining
individualized,
multimodal
efficient
management
for
each
individual
patient.
Pathogens,
Год журнала:
2023,
Номер
12(6), С. 766 - 766
Опубликована: Май 26, 2023
In
a
mutually
beneficial
connection
with
its
host,
the
gut
microbiota
affects
host's
nutrition,
immunity,
and
metabolism.
An
increasing
number
of
studies
have
shown
links
between
certain
types
disease
dysbiosis
or
specific
microorganisms.
Fecal
transplantation
(FMT)
is
strongly
advised
for
treatment
recurrent
resistant
Clostridium
difficile
infection
(CDI)
due
to
outstanding
clinical
effectiveness
against
CDI.
The
therapeutic
potential
FMT
other
disorders,
particularly
inflammatory
bowel
diseases
malignancies,
currently
gaining
more
attention.
We
summarized
most
recent
preclinical
evidence
show
promise
in
management
cancer
as
well
complications
related
after
reviewing
research
on
relationship
cancer.
