Abstract
Genetic
testing
plays
an
important
role
in
human
health
management
and
disease
prevention.
However,
traditional
genetic
methods
have
been
unable
to
fulfill
the
current
diagnostic
needs
owing
several
limitations,
including
high
cost,
complexity,
difficulty
performing.
Smartphones
multiple
inherent
advantages,
such
as
easy
portability,
ubiquity,
fast
processing
speed,
excellent
imaging
capabilities,
enormous
potential
realizing
rapid
on‐site
testing.
The
present
review
documents
research
progress
of
smartphone‐based
optical
biosensors
fields
colorimetry,
fluorescence,
microscopic
for
Furthermore,
describes
their
applications
diagnostics,
which
range
from
infectious
diseases
hereditary
cancers.
Finally,
challenges
perspectives
regarding
are
discussed.
Abstract
MXene
emerged
as
decent
2D
material
and
has
been
exploited
for
numerous
applications
in
the
last
decade.
The
remunerations
of
ideal
metallic
conductivity,
optical
absorbance,
mechanical
stability,
higher
heterogeneous
electron
transfer
rate,
good
redox
capability
have
made
a
potential
candidate
biosensing
applications.
hydrophilic
nature,
biocompatibility,
antifouling,
anti‐toxicity
properties
opened
avenues
to
perform
vitro
vivo
analysis.
In
this
review,
concept,
operating
principle,
detailed
mechanism,
characteristic
are
comprehensively
assessed
compiled
along
with
breakthroughs
fabrication
conjugation
strategies
development
unique
electrochemical
biosensors.
Further,
current
challenges
summarized
suggested
future
aspects.
This
review
article
is
believed
shed
some
light
on
will
open
new
opportunities
advanced
translational
application
bioassays.
Abstract
Sensing
devices
are
key
nodes
for
information
detection,
processing,
and
conversion
widely
applied
in
different
fields
such
as
industrial
production,
environmental
monitoring,
defense.
However,
increasing
demand
of
these
has
complicated
the
application
scenarios
diversified
detection
targets
thereby
promoting
continuous
development
sensing
materials
methods.
In
recent
years,
Ti
n+1
C
n
T
x
(
=
1,
2,
3)
MXenes
with
outstanding
optical,
electrical,
thermal,
mechanical
properties
have
been
developed
ideal
candidates
to
apply
physical,
chemical,
biological
fields.
this
review,
depending
on
optical
electrical
signals,
we
systematically
summarize
nine
categories
sensors
strain,
gas,
fluorescence
sensors.
The
excellent
allow
its
further
emerging
intelligent
bionic
devices,
including
smart
flexible
E-skin,
neural
network
coding
learning,
soft
robot,
well
artificial
eardrum,
which
all
discussed
briefly
review.
Finally,
present
a
positive
outlook
potential
future
challenges
perspectives
MXene-based
shown
vigorous
momentum
applications
can
drive
an
number
new
technologies.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Ноя. 4, 2022
MXene-based
nanozymes
have
garnered
considerable
attention
because
of
their
potential
environmental
and
biomedical
applications.
These
materials
encompass
alluring
manageable
catalytic
performances
physicochemical
features,
which
make
them
suitable
as
(bio)sensors
with
high
selectivity/sensitivity
efficiency.
structures
electrical
conductivity,
biocompatibility,
large
surface
area,
optical/magnetic
properties,
thermal/mechanical
features
can
be
applied
in
designing
innovative
area-dependent
electrocatalytic
performances.
Despite
the
advances
made,
there
is
still
a
long
way
to
deploy
nanozymes,
especially
medical
healthcare
applications;
limitations
pertaining
peroxidase-like
activity
sensitivity/selectivity
may
restrict
further
practical
applications
pristine
MXenes.
Thus,
developing
an
efficient
engineering
tactic
required
fabricate
multifunctional
excellent
activity.
To
obtain
unique
stability,
some
crucial
steps
such
hybridization
modification
ought
performed.
Notably,
(nano)toxicological
long-term
biosafety
analyses
along
clinical
translation
studies
need
comprehensively
addressed.
Although
very
limited
reports
exist
potentials
future
explorations
should
transition
toward
extensive
research
detailed
realize
additional
these
biomedicine
focus
on
industrial
aspects.
In
this
perspective,
therapeutic,
diagnostic,
theranostic
are
deliberated
perspectives
more
successful
translational
studies.
The
current
state-of-the-art
use
well
developmental
challenges
prospects
also
highlighted.
view
fascinating
properties
open
significant
new
opportunities
bio-
nanomedicine.
Abstract
Infectious
pathogens
cause
severe
human
illnesses
and
great
deaths
per
year
worldwide.
Rapid,
sensitive,
accurate
detection
of
is
importance
for
preventing
infectious
diseases
caused
by
optimizing
medical
healthcare
systems.
Inspired
a
microbial
defense
system
(i.e.,
CRISPR/
CRISPR‐associated
proteins
(Cas)
system,
an
adaptive
immune
protecting
microorganisms
from
being
attacked
invading
species),
many
new
biosensors
have
been
successfully
developed
widely
applied
in
the
viruses
pathogenic
bacteria.
Moreover,
advanced
nanotechnologies
also
integrated
into
these
to
improve
their
stability,
sensitivity,
accuracy.
In
this
review,
recent
advance
CRISPR/Cas
systems‐based
nano/biosensors
applications
bacteria
are
comprehensively
reviewed.
First
all,
categories
working
principles
systems
establishing
simply
introduced.
Then,
design
construction
discussed.
end,
attentions
focused
on
Impressively,
remaining
opportunities
challenges
further
development
system‐based
promising
proposed.
Chemical Communications,
Год журнала:
2024,
Номер
60(17), С. 2301 - 2319
Опубликована: Янв. 1, 2024
This
feature
article
summarises
the
latest
advances,
potential
challenges,
and
future
prospects
of
CRISPR/Cas
gene-editing
technologies
in
conjunction
with
emerging
nanodevices
for
refinement
precision
liquid
biopsy
techniques.
