2D MXene‐Based Biosensing: A Review

Small, Journal Year: 2022, Volume and Issue: 19(2)

Published: Nov. 22, 2022

Abstract MXene emerged as decent 2D material and has been exploited for numerous applications in the last decade. The remunerations of ideal metallic conductivity, optical absorbance, mechanical stability, higher heterogeneous electron transfer rate, good redox capability have made a potential candidate biosensing applications. hydrophilic nature, biocompatibility, antifouling, anti‐toxicity properties opened avenues to perform vitro vivo analysis. In this review, concept, operating principle, detailed mechanism, characteristic are comprehensively assessed compiled along with breakthroughs fabrication conjugation strategies development unique electrochemical biosensors. Further, current challenges summarized suggested future aspects. This review article is believed shed some light on will open new opportunities advanced translational application bioassays.

Language: Английский

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MXene sensors based on optical and electrical sensing signals: from biological, chemical, and physical sensing to emerging intelligent and bionic devices

PhotoniX, Journal Year: 2023, Volume and Issue: 4(1)

Published: May 5, 2023

Abstract Sensing devices are key nodes for information detection, processing, and conversion widely applied in different fields such as industrial production, environmental monitoring, defense. However, increasing demand of these has complicated the application scenarios diversified detection targets thereby promoting continuous development sensing materials methods. In recent years, Ti n+1 C n T x ( = 1, 2, 3) MXenes with outstanding optical, electrical, thermal, mechanical properties have been developed ideal candidates to apply physical, chemical, biological fields. this review, depending on optical electrical signals, we systematically summarize nine categories sensors strain, gas, fluorescence sensors. The excellent allow its further emerging intelligent bionic devices, including smart flexible E-skin, neural network coding learning, soft robot, well artificial eardrum, which all discussed briefly review. Finally, present a positive outlook potential future challenges perspectives MXene-based shown vigorous momentum applications can drive an number new technologies.

Language: Английский

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Fabrication of highly efficient Rh-doped cobalt–nickel-layered double hydroxide/MXene-based electrocatalyst with rich oxygen vacancies for hydrogen evolution

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 640, P. 338 - 347

Published: Feb. 27, 2023

Language: Английский

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Near-infrared light-activatable, analgesic nanocomposite delivery system for comprehensive therapy of diabetic wounds in rats

Biomaterials, Journal Year: 2024, Volume and Issue: 305, P. 122467 - 122467

Published: Jan. 7, 2024

Language: Английский

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DNA-encoded MXene-Pt nanozyme for enhanced colorimetric sensing of mercury ions

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 442, P. 136072 - 136072

Published: March 26, 2022

Language: Английский

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MXene-Based Composites as Nanozymes in Biomedicine: A Perspective

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: Nov. 4, 2022

MXene-based nanozymes have garnered considerable attention because of their potential environmental and biomedical applications. These materials encompass alluring manageable catalytic performances physicochemical features, which make them suitable as (bio)sensors with high selectivity/sensitivity efficiency. structures electrical conductivity, biocompatibility, large surface area, optical/magnetic properties, thermal/mechanical features can be applied in designing innovative area-dependent electrocatalytic performances. Despite the advances made, there is still a long way to deploy nanozymes, especially medical healthcare applications; limitations pertaining peroxidase-like activity sensitivity/selectivity may restrict further practical applications pristine MXenes. Thus, developing an efficient engineering tactic required fabricate multifunctional excellent activity. To obtain unique stability, some crucial steps such hybridization modification ought performed. Notably, (nano)toxicological long-term biosafety analyses along clinical translation studies need comprehensively addressed. Although very limited reports exist potentials future explorations should transition toward extensive research detailed realize additional these biomedicine focus on industrial aspects. In this perspective, therapeutic, diagnostic, theranostic are deliberated perspectives more successful translational studies. The current state-of-the-art use well developmental challenges prospects also highlighted. view fascinating properties open significant new opportunities bio- nanomedicine.

Language: Английский

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CRISPR/Cas Systems‐Inspired Nano/Biosensors for Detecting Infectious Viruses and Pathogenic Bacteria

Small Methods, Journal Year: 2022, Volume and Issue: 6(10)

Published: Sept. 16, 2022

Abstract Infectious pathogens cause severe human illnesses and great deaths per year worldwide. Rapid, sensitive, accurate detection of is importance for preventing infectious diseases caused by optimizing medical healthcare systems. Inspired a microbial defense system (i.e., CRISPR/ CRISPR‐associated proteins (Cas) system, an adaptive immune protecting microorganisms from being attacked invading species), many new biosensors have been successfully developed widely applied in the viruses pathogenic bacteria. Moreover, advanced nanotechnologies also integrated into these to improve their stability, sensitivity, accuracy. In this review, recent advance CRISPR/Cas systems‐based nano/biosensors applications bacteria are comprehensively reviewed. First all, categories working principles systems establishing simply introduced. Then, design construction discussed. end, attentions focused on Impressively, remaining opportunities challenges further development system‐based promising proposed.

Language: Английский

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CRISPR/Cas detection with nanodevices: moving deeper into liquid biopsy

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(17), P. 2301 - 2319

Published: Jan. 1, 2024

This feature article summarises the latest advances, potential challenges, and future prospects of CRISPR/Cas gene-editing technologies in conjunction with emerging nanodevices for refinement precision liquid biopsy techniques.

Language: Английский

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CRISPR integrated biosensors: A new paradigm for cancer detection

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 569, P. 120179 - 120179

Published: Feb. 1, 2025

Language: Английский

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Dual-Accelerated Signal Amplification in Biosensing via Spatial Confining Catalytic Hairpin Assembly-Activated Spherical CRISPR/Cas12a System for Trans-Cleavage of Hairpin DNA Reporters

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and implicated in various diseases, including cancer. Due to their critical role diagnostics, there is a growing need for sensitive, specific, rapid detection methods miRNAs. In this study, we present dual-accelerated signal amplification platform miRNA biosensing, which integrates spatial confining catalytic hairpin assembly (SC-CHA) with spherical CRISPR/Cas12a (S-CRISPR/Cas12a) system (SC-CHA@S-CRISPR/Cas12a) trans-cleavage of DNA reporters. The method employs biotinylated palindrome-rich sequence (PAS) form nanoballs, serve as scaffold the operation SC-CHA upon binding. products bind crRNA Cas 12a protein, activating S-CRISPR/Cas12a cleave reporter generate detectable fluorescence signal. uniqueness lies combined use nanoballs reporters, both significantly accelerate reaction kinetics, resulting generation. Additionally, nanostructure, integrated system, greatly enhances biostability accelerating kinetics. These features enable exhibit high sensitivity, limit (LOD) low 13.75 fM, excellent specificity, successfully distinguishing miRNA-21 from other assay also biostable, demonstrating reliable performance complex biological samples such human serum. This dual-acceleration approach offers promising solution rapid, specific potential applications early cancer diagnosis clinical monitoring.

Language: Английский

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