Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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Tumour microenvironment-responded Fe-doped carbon dots-sensitized cubic Cu2O for Z-scheme heterojunction-enhanced sono-chemodynamic synergistic tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 665, С. 681 - 692

Опубликована: Март 27, 2024

Язык: Английский

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Enhanced Efficacy of Immune Checkpoint Inhibitors by Folate-targeted Multifunctional Drug through Synergistic Therapy Inducing Ferroptosis and Immunogenic Cell Death in Bladder Cancer

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101584 - 101584

Опубликована: Фев. 21, 2025

Язык: Английский

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Sono-promoted piezocatalysis and low-dose drug penetration for personalized therapy via tumor organoids

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 675, С. 192 - 206

Опубликована: Июль 3, 2024

Язык: Английский

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Recent progress on photothermal nanomaterials: Design, mechanism, and applications

Green Energy & Environment, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Current advances in nanozyme-based nanodynamic therapies for cancer

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Injectable self-healing hydrogel as a rising therapeutic strategy for the loco-regional management of cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 98, С. 105913 - 105913

Опубликована: Июнь 26, 2024

Язык: Английский

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Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216207 - 216207

Опубликована: Сен. 13, 2024

Язык: Английский

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External Stimuli-Driven Catalytic Hydrogels for Biomedical Applications

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses design strategies for external stimuli-driven hydrogels with in situ catalytic processes. It highlights precise control over the properties, elucidating regulatory mechanisms and deepening understanding of applications.

Язык: Английский

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