Prodrug Self‐Assemblies Based on Plant Volatile Aldehydes with Improved Stability and Antimicrobial Activity Against Plant Pathogens DOI Open Access

Gaohua Hu,

Zhiyuan Zhou, Gang Tang

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Plant volatile aldehydes (PVAs) such as cinnamaldehyde (Cin), citral (Cit), citronellal (Citr), and perillaldehyde (Per) have broad-spectrum antimicrobial activity show great potential in agricultural sustainable production. However, most PVAs not only very high volatility but also are easily degradable environment, which seriously restricts their wide application. To address the inherent problems with PVAs, four prodrugs based on fabricated by conjugating individually Cin, Cit, Citr, Per to sodium bisulfite (Sod) through a simple addition reaction subsequently self-assembled into nanoparticles (prodrug self-assemblies) aqueous solutions. The results showed that pH of 7 temperature 35 °C optimal conditions for formation prodrug self-assemblies highest self-assembly rates. prepared spherical average particle sizes 100-200 nm, almost no volatilization, surface stability, can respond acidic redox microenvironments release PVAs. synergistic activities against Sclerotinia sclerotiorum Penicillium digitatum, good biological safety plants. Therefore, these findings important implications efficient utilization agriculture, ensuring ecological environment realizing development agriculture.

Язык: Английский

Carrier-free self-assembled nanoparticles based on prochloraz and fenhexamid for reducing toxicity to aquatic organism DOI
Zhiyuan Zhou, Gang Tang, Yulu Liu

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 943, С. 173821 - 173821

Опубликована: Июнь 12, 2024

Язык: Английский

Процитировано

6

Nanomaterial-based therapeutics for enhanced antifungal therapy DOI
Fang Liu, Yongcheng Chen, Yue Huang

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(37), С. 9173 - 9198

Опубликована: Янв. 1, 2024

The application of nanotechnology in antifungal therapy is gaining increasing attention. Current drugs have significant limitations, such as severe side effects, low bioavailability, and the rapid development resistance. Nanotechnology offers an innovative solution to address these issues. This review discusses three key strategies enhance efficacy. Firstly, nanomaterials can their interaction with fungal cells

Язык: Английский

Процитировано

4

Sustainable pest management using plant secondary metabolites regulated azadirachtin nano-assemblies DOI Creative Commons
Xiaohong Zhang, Jianhua Xiao, Yuqi Huang

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 18, 2025

Biopesticides have emerged as a global trend to minimize the risks associated with synthetic agrochemicals. However, their stability and efficacies remain challenges for widespread application. Herein, co-assembled nanoparticles (AT NPs or AP NPs) based on azadirachtin (AZA) tannic acid (TA) phenylalanine (PA) are constructed in aqueous solution through self-assembly technology. The small particle size, low PDI, high ζ-potential, related other physicochemical characteristics of can improve wettability, adhesiveness, rain erosion resistance, photostability compared commercial AZA formulation. Importantly, co-assemblies bidirectional pH-responsive disassembly acidic alkaline solutions, allow them respond microenvironmental stimuli targets enable controlled release AZA. nanosystems demonstrated remarkable vitro vivo insecticidal activities against Ostrinia furnacalis Aphis gossypii. This study illustrates distinctive perspective developing eco-friendly nanosystems, highlighting water-based treatment method biopesticides improved properties utilization efficiency. delivery limits Here, is plant secondary metabolites efficient drug delivery, demonstrating pest management, activation defensive capacity, while increasing production yield crops.

Язык: Английский

Процитировано

0

Prodrug self-assemblies based on acifluorfen and glucose for improving the effective utilization and reducing the risks to environment DOI
Jianhua Xiao, Gang Tang, Xiaohong Zhang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161382 - 161382

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Cocrystal engineering for sustained release of dicamba: Mitigating secondary drift and reducing leaching DOI

Chuanhua Wu,

Yuntian Xiao, Na Wang

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 375, С. 178 - 192

Опубликована: Сен. 10, 2024

Язык: Английский

Процитировано

2

Total Soluble Protein Mediated Morphological Traits in Mustard Treated with Thiourea and Salicylic Acid DOI Creative Commons
Shipa Rani Dey, Prasann Kumar, Joginder Singh

и другие.

Nature Environment and Pollution Technology, Год журнала: 2024, Номер 23(2), С. 679 - 694

Опубликована: Июнь 1, 2024

The total soluble protein-mediated morphological traits in mustard treated with Thiourea and Salicylic acid were investigated. In addition, it tested the hypothesis that growth regulator salicylic protects photosynthetic apparatus by up-regulating traits. Under natural environmental conditions, seeds sown field, seed emergence was recorded. For three days after 15-day stage, plants area thiourea allowed to grow for 90 days. Plants harvested assess various A follow-up application of SA improved plant height, leaf area, internodal length, number, accelerated activity. up-regulation may have occurred Thiourea-mediated plants. After treatments, level protein estimated leaves at proposed day intervals.

Язык: Английский

Процитировано

1

Unraveling the Potential of Vitamin B3-Derived Salts with a Salicylate Anion as Dermal Active Agents for Acne Treatment DOI Creative Commons
Adriana Olejniczak, Witold Stachowiak, Daniel Ziental

и другие.

Molecular Pharmaceutics, Год журнала: 2024, Номер 21(9), С. 4634 - 4647

Опубликована: Авг. 14, 2024

This study is focused on the utilization of naturally occurring salicylic acid and nicotinamide (vitamin B

Язык: Английский

Процитировано

1

Fabrication of zein-coated brush-like silica naoncarriers for high foliage deposition and responsive release of pesticide DOI
Yuting Zhang, Tao Hong,

Menghui Wan

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 241, С. 114061 - 114061

Опубликована: Июнь 26, 2024

Язык: Английский

Процитировано

0

pH and Pectinase Dual-Responsive Zinc Oxide Core-Shell Nanopesticide: Efficient Control of Sclerotinia Disease and Reduction of Environmental Risks DOI Creative Commons

Qiongmei Mai,

Yu Lu,

Qianyu Cai

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(24), С. 2022 - 2022

Опубликована: Дек. 16, 2024

Sclerotinia sclerotiorum is one of the fungi that cause plant diseases. It damages plants by secreting large amounts oxalic acid and cell wall-degrading enzymes. To meet this challenge, we designed a new pH/enzyme dual-responsive nanopesticide Pro@ZnO@Pectin (PZP). This uses zinc oxide (ZnO) as carrier prochloraz (Pro) encapsulated with pectin. When encountering released sclerotiorum, acidic environment promotes decomposition ZnO; at same time, pectinase produced can also decompose outer pectin layer PZP, thereby promoting effective release active ingredient. Experimental data showed PZP was able to achieve an efficient rate 57.25% 68.46% when added or under conditions, respectively. In addition, in vitro tests antifungal effect comparable commercial Pro (Pro SC) on market, its efficacy 1.40 times 1.32 original drug TC), Crucially, application significantly alleviated detrimental impacts wheat development. Soil wetting experiments have proved primarily remained soil, decreasing likelihood contaminating water sources reducing potential risks non-target organisms. Moreover, improved foliar wettability Pro, lowering contact angle 75.06°. Residue analyses indicated did not elevate residue levels tomato fruits compared conventional applications, indicating formulation does lead excessive pesticide buildup. summary, shows great promise for effectively managing while minimizing environmental impact.

Язык: Английский

Процитировано

0

Prodrug Self‐Assemblies Based on Plant Volatile Aldehydes with Improved Stability and Antimicrobial Activity Against Plant Pathogens DOI Open Access

Gaohua Hu,

Zhiyuan Zhou, Gang Tang

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Plant volatile aldehydes (PVAs) such as cinnamaldehyde (Cin), citral (Cit), citronellal (Citr), and perillaldehyde (Per) have broad-spectrum antimicrobial activity show great potential in agricultural sustainable production. However, most PVAs not only very high volatility but also are easily degradable environment, which seriously restricts their wide application. To address the inherent problems with PVAs, four prodrugs based on fabricated by conjugating individually Cin, Cit, Citr, Per to sodium bisulfite (Sod) through a simple addition reaction subsequently self-assembled into nanoparticles (prodrug self-assemblies) aqueous solutions. The results showed that pH of 7 temperature 35 °C optimal conditions for formation prodrug self-assemblies highest self-assembly rates. prepared spherical average particle sizes 100-200 nm, almost no volatilization, surface stability, can respond acidic redox microenvironments release PVAs. synergistic activities against Sclerotinia sclerotiorum Penicillium digitatum, good biological safety plants. Therefore, these findings important implications efficient utilization agriculture, ensuring ecological environment realizing development agriculture.

Язык: Английский

Процитировано

0