Prodrug Self‐Assemblies Based on Plant Volatile Aldehydes with Improved Stability and Antimicrobial Activity Against Plant Pathogens DOI Open Access

Gaohua Hu,

Zhiyuan Zhou, Gang Tang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Plant volatile aldehydes (PVAs) such as cinnamaldehyde (Cin), citral (Cit), citronellal (Citr), and perillaldehyde (Per) have broad-spectrum antimicrobial activity show great potential in agricultural sustainable production. However, most PVAs not only very high volatility but also are easily degradable environment, which seriously restricts their wide application. To address the inherent problems with PVAs, four prodrugs based on fabricated by conjugating individually Cin, Cit, Citr, Per to sodium bisulfite (Sod) through a simple addition reaction subsequently self-assembled into nanoparticles (prodrug self-assemblies) aqueous solutions. The results showed that pH of 7 temperature 35 °C optimal conditions for formation prodrug self-assemblies highest self-assembly rates. prepared spherical average particle sizes 100-200 nm, almost no volatilization, surface stability, can respond acidic redox microenvironments release PVAs. synergistic activities against Sclerotinia sclerotiorum Penicillium digitatum, good biological safety plants. Therefore, these findings important implications efficient utilization agriculture, ensuring ecological environment realizing development agriculture.

Language: Английский

Carrier-free self-assembled nanoparticles based on prochloraz and fenhexamid for reducing toxicity to aquatic organism DOI
Zhiyuan Zhou, Gang Tang, Yulu Liu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 943, P. 173821 - 173821

Published: June 12, 2024

Language: Английский

Citations

6
Nanomaterial-based therapeutics for enhanced antifungal therapy DOI
Fang Liu, Yongcheng Chen, Yue Huang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(37), P. 9173 - 9198

Published: Jan. 1, 2024

The application of nanotechnology in antifungal therapy is gaining increasing attention. Current drugs have significant limitations, such as severe side effects, low bioavailability, and the rapid development resistance. Nanotechnology offers an innovative solution to address these issues. This review discusses three key strategies enhance efficacy. Firstly, nanomaterials can their interaction with fungal cells

Language: Английский

Citations

4
Sustainable pest management using plant secondary metabolites regulated azadirachtin nano-assemblies DOI Creative Commons
Xiaohong Zhang, Jianhua Xiao, Yuqi Huang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 18, 2025

Biopesticides have emerged as a global trend to minimize the risks associated with synthetic agrochemicals. However, their stability and efficacies remain challenges for widespread application. Herein, co-assembled nanoparticles (AT NPs or AP NPs) based on azadirachtin (AZA) tannic acid (TA) phenylalanine (PA) are constructed in aqueous solution through self-assembly technology. The small particle size, low PDI, high ζ-potential, related other physicochemical characteristics of can improve wettability, adhesiveness, rain erosion resistance, photostability compared commercial AZA formulation. Importantly, co-assemblies bidirectional pH-responsive disassembly acidic alkaline solutions, allow them respond microenvironmental stimuli targets enable controlled release AZA. nanosystems demonstrated remarkable vitro vivo insecticidal activities against Ostrinia furnacalis Aphis gossypii. This study illustrates distinctive perspective developing eco-friendly nanosystems, highlighting water-based treatment method biopesticides improved properties utilization efficiency. delivery limits Here, is plant secondary metabolites efficient drug delivery, demonstrating pest management, activation defensive capacity, while increasing production yield crops.

Language: Английский

Citations

0
Prodrug self-assemblies based on acifluorfen and glucose for improving the effective utilization and reducing the risks to environment DOI
Jianhua Xiao, Gang Tang, Xiaohong Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161382 - 161382

Published: March 1, 2025

Language: Английский

Citations

0
Cocrystal engineering for sustained release of dicamba: Mitigating secondary drift and reducing leaching DOI

Chuanhua Wu,

Yuntian Xiao, Na Wang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 178 - 192

Published: Sept. 10, 2024

Language: Английский

Citations

2
Total Soluble Protein Mediated Morphological Traits in Mustard Treated with Thiourea and Salicylic Acid DOI Creative Commons
Shipa Rani Dey, Prasann Kumar, Joginder Singh

et al.

Nature Environment and Pollution Technology, Journal Year: 2024, Volume and Issue: 23(2), P. 679 - 694

Published: June 1, 2024

The total soluble protein-mediated morphological traits in mustard treated with Thiourea and Salicylic acid were investigated. In addition, it tested the hypothesis that growth regulator salicylic protects photosynthetic apparatus by up-regulating traits. Under natural environmental conditions, seeds sown field, seed emergence was recorded. For three days after 15-day stage, plants area thiourea allowed to grow for 90 days. Plants harvested assess various A follow-up application of SA improved plant height, leaf area, internodal length, number, accelerated activity. up-regulation may have occurred Thiourea-mediated plants. After treatments, level protein estimated leaves at proposed day intervals.

Language: Английский

Citations

1
Unraveling the Potential of Vitamin B3-Derived Salts with a Salicylate Anion as Dermal Active Agents for Acne Treatment DOI Creative Commons
Adriana Olejniczak, Witold Stachowiak, Daniel Ziental

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(9), P. 4634 - 4647

Published: Aug. 14, 2024

This study is focused on the utilization of naturally occurring salicylic acid and nicotinamide (vitamin B

Language: Английский

Citations

1
Fabrication of zein-coated brush-like silica naoncarriers for high foliage deposition and responsive release of pesticide DOI
Yuting Zhang, Tao Hong,

Menghui Wan

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114061 - 114061

Published: June 26, 2024

Language: Английский

Citations

0
pH and Pectinase Dual-Responsive Zinc Oxide Core-Shell Nanopesticide: Efficient Control of Sclerotinia Disease and Reduction of Environmental Risks DOI Creative Commons

Qiongmei Mai,

Yu Lu,

Qianyu Cai

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(24), P. 2022 - 2022

Published: Dec. 16, 2024

Sclerotinia sclerotiorum is one of the fungi that cause plant diseases. It damages plants by secreting large amounts oxalic acid and cell wall-degrading enzymes. To meet this challenge, we designed a new pH/enzyme dual-responsive nanopesticide Pro@ZnO@Pectin (PZP). This uses zinc oxide (ZnO) as carrier prochloraz (Pro) encapsulated with pectin. When encountering released sclerotiorum, acidic environment promotes decomposition ZnO; at same time, pectinase produced can also decompose outer pectin layer PZP, thereby promoting effective release active ingredient. Experimental data showed PZP was able to achieve an efficient rate 57.25% 68.46% when added or under conditions, respectively. In addition, in vitro tests antifungal effect comparable commercial Pro (Pro SC) on market, its efficacy 1.40 times 1.32 original drug TC), Crucially, application significantly alleviated detrimental impacts wheat development. Soil wetting experiments have proved primarily remained soil, decreasing likelihood contaminating water sources reducing potential risks non-target organisms. Moreover, improved foliar wettability Pro, lowering contact angle 75.06°. Residue analyses indicated did not elevate residue levels tomato fruits compared conventional applications, indicating formulation does lead excessive pesticide buildup. summary, shows great promise for effectively managing while minimizing environmental impact.

Language: Английский

Citations

0
Prodrug Self‐Assemblies Based on Plant Volatile Aldehydes with Improved Stability and Antimicrobial Activity Against Plant Pathogens DOI Open Access

Gaohua Hu,

Zhiyuan Zhou, Gang Tang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Plant volatile aldehydes (PVAs) such as cinnamaldehyde (Cin), citral (Cit), citronellal (Citr), and perillaldehyde (Per) have broad-spectrum antimicrobial activity show great potential in agricultural sustainable production. However, most PVAs not only very high volatility but also are easily degradable environment, which seriously restricts their wide application. To address the inherent problems with PVAs, four prodrugs based on fabricated by conjugating individually Cin, Cit, Citr, Per to sodium bisulfite (Sod) through a simple addition reaction subsequently self-assembled into nanoparticles (prodrug self-assemblies) aqueous solutions. The results showed that pH of 7 temperature 35 °C optimal conditions for formation prodrug self-assemblies highest self-assembly rates. prepared spherical average particle sizes 100-200 nm, almost no volatilization, surface stability, can respond acidic redox microenvironments release PVAs. synergistic activities against Sclerotinia sclerotiorum Penicillium digitatum, good biological safety plants. Therefore, these findings important implications efficient utilization agriculture, ensuring ecological environment realizing development agriculture.

Language: Английский

Citations

0