Food & Function,
Год журнала:
2024,
Номер
15(16), С. 8395 - 8407
Опубликована: Янв. 1, 2024
Capsaicin
(CAP),
the
active
ingredient
in
hot
chilli
peppers,
has
anti-inflammatory
and
hepatoprotection
effects.
Acute
alcoholic
liver
injury
(AALI)
is
damage
caused
by
acute
alcohol
abuse,
which
can
lead
to
severe
lesions
even
be
life-threatening.
Pyroptosis
inflammation-related
programmed
cell
death
characterized
membrane
rupture
plays
a
key
role
AALI.
The
endosomal
sorting
complexes
required
for
transport
(ESCRT)
proteins
gather
at
damaged
areas
of
facilitate
process
sealing
membrane.
In
this
study,
we
found
that
CAP
could
relieve
alcohol-induced
pyroptosis
hepatocytes
vitro
vivo.
Mechanically,
alleviate
activating
ESCRT-III-dependent
repair
machinery.
Furthermore,
data
showed
induced
ESCRT-III
protein
expression
transient
receptor
potential
vanilloid
member
1
(TRPV1)
on
Ca2+
influx.
TRPV1
inhibitor
capsazepine
(CPZ)
inhibited
relief
effect
pyroptosis.
Overall,
these
results
might
activate
machinery
through
influx,
regulated
calcium
channels,
therefore
mitigating
Our
research
provides
new
perspective
naturally
food
product
promote
Journal of Clinical Investigation,
Год журнала:
2024,
Номер
134(3)
Опубликована: Фев. 1, 2024
Alcohol-associated
liver
disease
(ALD)
is
a
major
cause
of
chronic
worldwide,
and
comprises
spectrum
several
different
disorders,
including
simple
steatosis,
steatohepatitis,
cirrhosis,
superimposed
hepatocellular
carcinoma.
Although
tremendous
progress
has
been
made
in
the
field
ALD
over
last
20
years,
pathogenesis
remains
obscure,
there
are
currently
no
FDA-approved
drugs
for
treatment
ALD.
In
this
Review,
we
discuss
new
insights
into
therapeutic
targets
ALD,
utilizing
study
multiomics
other
cutting-edge
approaches.
The
potential
translation
these
studies
clinical
practice
therapy
deliberated.
We
also
preclinical
models
interplay
metabolic
dysfunction,
alcohol-associated
cancer,
heterogeneity
some
translational
research
prospects
Hepatology,
Год журнала:
2024,
Номер
80(6), С. 1342 - 1371
Опубликована: Май 1, 2024
The
growing
recognition
of
the
role
gut
microbiome’s
impact
on
alcohol-associated
diseases,
especially
in
liver
disease,
emphasizes
need
to
understand
molecular
mechanisms
involved
governing
organ-organ
communication
identify
novel
avenues
combat
diseases.
gut-liver
axis
refers
bidirectional
and
interaction
between
liver.
Intestinal
microbiota
plays
a
pivotal
maintaining
homeostasis
within
axis,
this
significant
disease.
intricate
intestine
involves
multiple
cellular
components
each
organ
that
enable
them
carry
out
their
physiological
functions.
In
review,
we
focus
approaches
understanding
how
chronic
alcohol
exposure
impacts
microbiome
individual
cells
intestine,
as
well
ethanol
machinery
required
for
intraorgan
interorgan
communication.
Cellular and Molecular Gastroenterology and Hepatology,
Год журнала:
2024,
Номер
18(3), С. 101352 - 101352
Опубликована: Янв. 1, 2024
Alcohol-associated
hepatitis
(AH)
is
an
acute-on-chronic
liver
injury
that
occurs
in
patients
with
chronic
alcohol-associated
disease
(ALD).
Patients
severe
AH
have
high
short-term
mortality
and
lack
effective
pharmacologic
therapies.
Inflammation
believed
to
be
one
of
the
key
factors
promoting
progression
has
been
actively
investigated
as
therapeutic
targets
over
last
several
decades,
but
no
inflammatory
identified
so
far.
In
this
review,
we
discuss
how
cells
mediators
produced
by
these
contribute
development
AH,
focus
on
neutrophils
macrophages.
The
crosstalk
between
nonparenchymal
pathogenesis
elaborated.
We
also
deliberate
application
recent
cutting-edge
technologies
characterizing
inflammation
AH.
Finally,
potential
for
are
briefly
summarized.
Clinical and Molecular Hepatology,
Год журнала:
2024,
Номер
30(4), С. 620 - 648
Опубликована: Июль 11, 2024
Steatotic
liver
diseases
(SLD)
are
the
principal
worldwide
cause
of
cirrhosis
and
end-stage
cancer,
affecting
nearly
a
quarter
global
population.
SLD
includes
metabolic
dysfunction-associated
alcoholic
disease
(MetALD)
steatotic
(MASLD),
resulting
in
asymptomatic
steatosis,
fibrosis,
associated
complications.
The
immune
processes
include
gut
dysbiosis,
adiposeliver
organ
crosstalk,
hepatocyte
death
cell-mediated
inflammatory
processes.
Notably,
various
cells
such
as
B
cells,
plasma
dendritic
conventional
CD4<sup>+</sup>
CD8<sup>+</sup>
T
innate-like
platelets,
neutrophils
macrophages
play
vital
roles
development
MetALD
MASLD.
Immunological
modulations
targeting
death,
reactions
microbiome
N-acetylcysteine,
selonsertib,
F-652,
prednisone,
pentoxifylline,
anakinra,
JKB-121,
HA35,
obeticholic
acid,
probiotics,
prebiotics,
antibiotics
fecal
microbiota
transplantation.
Understanding
immunological
mechanisms
underlying
is
crucial
for
advancing
clinical
therapeutic
strategies.
AJP Gastrointestinal and Liver Physiology,
Год журнала:
2024,
Номер
326(5), С. G483 - G494
Опубликована: Март 5, 2024
Fatty
acid
oxidation
(FAO)
releases
the
energy
stored
in
fat
to
maintain
basic
biological
processes.
Dehydrogenation
is
a
major
way
oxidize
fatty
acids,
which
needs
NAD
Mitochondria
are
intracellular
organelles
responsible
for
energy
production,
glucose
and
lipid
metabolism,
cell
death,
proliferation,
innate
immune
response.
highly
dynamic
that
constantly
undergo
fission,
fusion,
trafficking,
as
well
degradation
biogenesis.
Mitochondrial
dysfunction
has
been
implicated
in
a
variety
of
chronic
liver
diseases
including
alcohol-associated
disease,
metabolic
dysfunction–associated
steatohepatitis,
HCC.
In
this
review,
we
provide
detailed
overview
mitochondrial
dynamics,
mitophagy,
DNA–mediated
response,
how
dysregulation
these
processes
affects
the
pathogenesis
disease
dynamics
response
may
thereby
represent
an
attractive
therapeutic
target
ameliorating
