Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery

Theranostics, Год журнала: 2018, Номер 8(4), С. 1131 - 1145

Опубликована: Янв. 1, 2018

Activation of the vascular endothelium is characterized by increased expression adhesion molecules and chemokines.This activation occurs early in progression several diseases triggers recruitment leukocytes.Inspired tropism leukocytes, we investigated leukocyte-based biomimetic nanoparticles (i.e., leukosomes) as a novel theranostic platform for inflammatory diseases.Methods: Leukosomes were assembled combining phospholipids membrane proteins from leukocytes.For imaging applications, modified with rhodamine gadolinium used.Leukosomes incubated antibodies blocking lymphocyte function-associated antigen 1 (LFA-1) CD45 administered to explore their roles targeting inflammation.In addition, relaxometric assessment NPs was evaluated.Results: Liposomes leukosomes both spherical shape sizes ranging 140-170 nm.Both successfully integrated 8 13 µg gadolinium, respectively, demonstrated less than 4% variation physicochemical features.Leukosomes 16-fold increase breast tumor accumulation relative liposomes.Furthermore, quantification vessels 4.5-fold vessel lumens 14-fold walls.Investigating mechanism action revealed that blockage LFA-1 on resulted 95% decrease accumulation.Whereas yielded 60% significant increases liver spleen accumulation.In when mice atherosclerotic plaques, exhibited 4-fold lesions.Lastly, incorporation into did not impact r1 r2 relaxivities NPs, demonstrating 6 30 mM -1 s , respectively.Conclusion: Our study demonstrates ability target activated vasculature exhibit superior tumors lesions.The versatility phospholipid backbone within permits various contrast agents.Furthermore, can potentially be loaded therapeutics possessing diverse physical properties thus warrant further investigation toward development powerful agents.

Язык: Английский

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Erythrocytes as Carriers: From Drug Delivery to Biosensors

Pharmaceutics, Год журнала: 2020, Номер 12(3), С. 276 - 276

Опубликована: Март 18, 2020

Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug's action due to its gradual release from carrier; bioreactors with encapsulated enzymes performing necessary reactions, while remaining inaccessible immune system and plasma proteases; or tool for targeted drug target organs, primarily cells of reticuloendothelial system, liver spleen. To date, have been studied wide range drugs, such enzymes, antibiotics, anti-inflammatory, antiviral etc., diagnostic purposes (e.g. magnetic resonance imaging). The review focuses only on drugs loaded inside defines main lines research bioactive substances, well advantages limitations their application. Particular attention paid in vivo studies, opening-up potential clinical use into erythrocytes.

Язык: Английский

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Overcoming Hypoxia-Restrained Radiotherapy Using an Erythrocyte-Inspired and Glucose-Activatable Platform

Nano Letters, Год журнала: 2020, Номер 20(6), С. 4211 - 4219

Опубликована: Апрель 30, 2020

Radiotherapy (RT) as one of the most powerful cancer treatment strategies has been greatly restricted by tumor hypoxia. A mounting effort devoted to develop oxygen delivery systems for boosting RT effect. Unluckily, those only supplied modest oxygen, which could not afford more than once and long-time RT. Herein, we describe development a glucose-regulated drug release platform, allowing long-term normoxic microenvironment repeated long time. The cycles resulted in sustained high Endostar plasma levels, dramatically normalized vasculature chronically reversed Taking advantage inexhaustible supply Endo@GOx-ER enabled achieved an impressive output. To best our knowledge, strategy is initial attempt overcome tumor-hypoxia-limited through normalization using erythrocyte-inspired glucose-activatable platform it visually casts light on clinical development.

Язык: Английский

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Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

Chemical Society Reviews, Год журнала: 2022, Номер 51(23), С. 9759 - 9830

Опубликована: Янв. 1, 2022

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing to kill tumor cells.

Язык: Английский

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Tumor Associated Macrophages and TAMs‐Based Anti‐Tumor Nanomedicines

Advanced Healthcare Materials, Год журнала: 2021, Номер 10(18)

Опубликована: Июль 22, 2021

As an important part of tumor microenvironment, associated macrophages (TAMs) play a vital role in the occurrence, development, invasion, and metastasis many malignant tumors can significantly promote formation blood vessels lymphatic vessels, hence TAMs are greatly with poor prognosis. The research on nanomedicine has achieved huge progress, nano-drugs have been widely utilized to treat various diseases through different mechanisms. Therefore, developing that based TAMs-associated anti-tumor mechanisms effectively suppress growth is expected be promising filed. This paper introduces relevant information about terms their origin, roles genesis, development metastasis. Furthermore, TAMs-related summarized. Specifically, wide range targeting at introduced, categorized according therapeutic toward tumors. Additionally, nano delivery platforms using as cell carriers which aim inhibiting reviewed. These two parts elucidate exploration essential study strategies. review also intended provide novel ideas for in-depth investigation molecular nano-drug systems TAMs.

Язык: Английский

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