Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(18), С. 3925 - 3934
Опубликована: Янв. 1, 2021
We creatively designed a nanodrug delivery system of MnO2-PTX/Ce6@lips based on the catalytic activity MnO2 NPs. synthesized highly dispersible catalase-like nanozyme and successfully encapsulated it into liposomes.
Язык: Английский
Chemical Society Reviews, Год журнала: 2020, Номер 50(2), С. 945 - 985
Опубликована: Ноя. 23, 2020
Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. primitives are characterized by distinctive biological functions, such long-term circulation, tumor specific targeting, immune modulation etc. Moreover, synthetic nanomaterials featuring unique physical/chemical properties been widely used effective drug delivery vehicles or anticancer to treat cancer. The combination these two kinds will catalyze generation innovative biomaterials with multiple high biocompatibility negligible immunogenicity precise In this review, we summarize most recent advances in development cell Different primitives, including bacteria, phages, cells, membranes, other bioactive introduced their strategies combining materials, especially nanoparticulate systems, construction function-enhanced also summarized. Furthermore, foreseeable challenges future perspectives included research direction field.
Язык: Английский
Процитировано
146
Advanced Materials, Год журнала: 2022, Номер 34(41)
Опубликована: Авг. 26, 2022
Currently, the role of lysosome, endoplasmic reticulum, or dictyosome in transcription and translation programmed cell death ligand 1 (PD-L1) is well revealed, but function mitochondria PD-L1 expression tumors still not fully researched, making it hard to offer a novel regulation strategy. In this research, newly revealed that oxidative phosphorylation (OXPHOS) depression can be used as an effective down-regulation method. To ideal high-effective tumor mitochondria-targeted OXPHOS nanosystem, IR-LND prepared by conjugating heptamethine cyanine dye IR-68 with mitochondrial complexes I II agent lonidamine (LND), which then further self-assembled albumin (Alb) form IR-LND@Alb nanoparticles. By doing this, selectively effectively depressed As expected, anti-tumor efficacy such strategy superior conventional anti-PD-L1 monoclonal antibodies. Interestingly, also served promising photodynamic therapy (PDT) drug self-oxygen self-PD-L1 capacity. All all, tumor-selective metabolic reprogramming platform reactivate immunotherapy sensitize for PDT effect, would open new window cancer patients.
Язык: Английский
Процитировано
93
Advanced Materials, Год журнала: 2024, Номер 36(15)
Опубликована: Фев. 2, 2024
Abstract Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella ‐loaded poly(ionic liquid)‐based microneedles (PILMN‐Chl) constructed for microacupuncture oxygen antibacterial therapy against methicillin‐resistant Staphylococcus aureus (MRSA)‐infected The PILMN‐Chl can stably continuously produce more than 30 h due to the photosynthesis of loaded self‐supported . By combining barrier penetration capabilities microneedles, continuous sufficient supply , sterilization activities PIL, accelerate wounds vivo by topical targeted hypoxia relief deep parts Thus, self‐oxygen produced modality may provide a promising facile therapeutic strategy treating chronic, hypoxic, infected
Язык: Английский
Процитировано
44
ACS Nano, Год журнала: 2020, Номер 14(12), С. 16840 - 16853
Опубликована: Ноя. 16, 2020
Photodynamic therapy (PDT), a noninvasive therapeutic strategy for cancer treatment, which always suffers from the low reactive oxygen species (ROS) yield of traditional organic dyes. Herein, we present lipid-encapsulated aggregation-induced emission nanoparticles (AIE NPs) that have high quantum (23%) and maximum two-photon absorption (TPA) cross-section 560 GM irradiated by near-infrared light (800 nm). The AIE NPs can serve as imaging agents spatiotemporal tumor tissues with penetration depth up to 505 μm on mice melanoma model. Importantly, simultaneously generate singlet (1O2) highly toxic hydroxyl radicals (•OH) upon irradiation 800 nm photodynamic ablation. In addition, be effectively cleared mouse body after therapy. This study provides develop theranostic image-guided PDT brightness, superior photostability, biosafety.
Язык: Английский
Процитировано
89
Advanced Materials, Год журнала: 2021, Номер 33(50)
Опубликована: Июнь 13, 2021
Abstract Numerous clinical trials for cancer precision medicine research are limited due to the drug resistance, side effects, and low efficacy. Unsatisfactory outcomes often caused by complex physiologic barriers abnormal immune events in tumors, such as tumor target alterations immunosuppression. Cell/bacteria‐derived materials with unique bioactive properties have emerged attractive tools personalized therapy cancer. Naturally derived materials, cell bacterial therapeutic agents native tropism or good biocompatibility, can precisely tumors effectively modulate microenvironments inhibit tumors. Here, recent advances development of cell/bacteria‐based modulation summarized. Cell/bacterial constituents, including membranes, vesicles, other active substances inherited their targeting antitumor capabilities. Strategies engineering living cell/bacteria overcome biological immunosuppression promote efficacy also Moreover, past ongoing involving promising micro/nano‐biorobotics further discussed, which may become another powerful tool treatment near future.
Язык: Английский
Процитировано
85
Chemical Society Reviews, Год журнала: 2022, Номер 51(23), С. 9759 - 9830
Опубликована: Янв. 1, 2022
Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing to kill tumor cells.
Язык: Английский
Процитировано
68
ACS Nano, Год журнала: 2022, Номер 16(4), С. 5439 - 5453
Опубликована: Март 31, 2022
Hypoxia, the typical and conspicuous characteristic of most solid tumors, worsens tumor invasiveness metastasis. Here, we engineered a sequential ultrasound (US)/hypoxia-sensitive sonochemotherapeutic nanoprodrug by initially synthesizing hypoxia-activated azo bond-containing camptothecin (CPT) prodrug (CPT2-Azo) then immobilizing it into mesopores sonosensitizer-integrated metal organic frameworks (MOF NPs). Upon entering hypoxic microenvironment (TME), structure CPT2-Azo immobilized MOFs (denoted as MCA) was ruptured loaded nontoxic released from MOF NPs. Under US actuation, this not only promoted sonosensitizer-mediated sonodynamic therapy (SDT) via conversion oxygen cytotoxic reactive species (ROS) but also aggravated hypoxia in TME elevating consumption. The exacerbated turn served positive amplifier to boost activation CPT2-Azo, controllable release toxic chemotherapeutic drug (CPT), compensated insufficient treatment efficacy SDT. In vitro vivo evaluations confirmed that SDT sonochemotherapy utmost thereby contributed augmented antitumor efficacy, resulting apoptotic cell death noteworthy suppression vivo. Our work provides distinctive insight exploitation utilizes condition TME, side effect SDT, initiate chemotherapy, thus causing significantly outcome compared conventional
Язык: Английский
Процитировано
66
ACS Nano, Год журнала: 2022, Номер 16(12), С. 20805 - 20819
Опубликована: Ноя. 15, 2022
The emergence of X-ray-induced photodynamic therapy (X-PDT) holds tremendous promise for clinical deep-penetrating cancer therapy. However, the application X-PDT in treatment is still limited due to hypoxic property cancerous tissue, inherent antioxidant system tumor cells, and difficulty matching absorption spectra photosensitizers. Herein, a versatile core–shell radiosensitizer (SCNPs@DMSN@CeOx-PEG, denoted as SSCP) was elaborately designed constructed enhance by coating tunable mesoporous silica on nanoscintillators, followed embedding cerium oxide nanoparticles situ. obtained SSCP demonstrated distinct blue-shift ultraviolet light region, so that it could perfectly absorb converted SCNPs core, resulting formation photoinduced electron–hole (e–-h+) pairs separation generate reactive oxygen species (ROS). In addition, exhibits high glutathione consumption heighten ROS accumulation, catalase-like activity alleviate hypoxia, which further enhances efficiency radiotherapy. Benefiting from abundant Lu Ce elements, computed tomography imaging performance about 3.79-fold contrast agent (iohexol), has great potential both preclinical translation.
Язык: Английский
Процитировано
56
Chemical Engineering Journal, Год журнала: 2023, Номер 468, С. 143685 - 143685
Опубликована: Май 22, 2023
Язык: Английский
Процитировано
31
Small, Год журнала: 2024, Номер 20(35)
Опубликована: Апрель 23, 2024
Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles tumor diagnosis treatment lie their ability to target delivery, minimizing toxicity normal tissues while enhancing therapeutic efficacy. Moreover, responsiveness both endogenous exogenous stimuli opens up new possibilities integrating multiple modalities. This review scrutinizes the burgeoning utility combination with chemotherapy other Commencing elucidation synthesis degradation mechanisms, emphasis placed on these materials (e.g., pH, redox reactions, hypoxia, enzymes) light high-intensity focused ultrasound). this exploration delves into strategies harnessing alone, coupled radiotherapy, photothermal therapy, photodynamic gas immunotherapy, starvation chemodynamic elucidating multimodal synergies. Concluding an assessment advances, challenges, constraints oncology, despite hurdles, future investigations are anticipated augment role cancer therapy. These insights can serve a compass devising more efficacious combined strategies.
Язык: Английский
Процитировано
11