Nanoparticle‐Mediated Radiotherapy Remodels the Tumor Microenvironment to Enhance Antitumor Efficacy

Advanced Materials, Год журнала: 2022, Номер 35(21)

Опубликована: Дек. 16, 2022

Radiotherapy (RT) uses ionizing radiation to eradicate localized tumors and, in rare cases, control outside of the irradiated fields via stimulating an antitumor immune response (abscopal effect). However, therapeutic effect RT is often limited by inherent physiological barriers tumor microenvironment (TME), such as hypoxia, abnormal vasculature, dense extracellular matrix (ECM), and immunosuppressive TME. Thus, it critical develop new strategies that can remodel TME overcome radio-resistance suppression. In past decade, high-Z-element nanoparticles have been developed increase radiotherapeutic indices reducing X-ray doses side effects normal tissues enhance abscopal activating elicit systemic immunity. this review, principles radiosensitization, mechanisms suppression, use various sensitize TMEs for enhanced efficacy are discussed. The challenges clinical translation multifunctional TME-remodeling nanoradiosensitizers also highlighted.

Язык: Английский

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Biomarker-driven molecular imaging probes in radiotherapy

Theranostics, Год журнала: 2024, Номер 14(10), С. 4127 - 4146

Опубликована: Янв. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Язык: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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Engineered Living Materials for Advanced Diseases Therapy

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Июль 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Язык: Английский

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Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(13), С. 8991 - 9003

Опубликована: Март 21, 2024

Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λem = 1105 nm), as first example Ru(II) supramolecular ICD inducer. synergistically potentiates immunomodulatory and reduces adverse through multiple regulated approaches, including NIR-light excitation, increased reactive oxygen species (ROS) generation, selective targeting tumor cells, precision organelle localization, improved penetration/retention capabilities. Specifically, demonstrates excellent depth-activated ROS production (∼1 cm), resistance to diffusion, anti-ROS quenching. Moreover, exhibits promising results cellular uptake generation cancer cells multicellular spheroids. Importantly, induces more efficient an ultralow dose (10 μM) compared conventional agent, oxaliplatin (300 μM). In vivo experiments further confirm Ru1105's potency inducer, eliciting CD8+ T depleting Foxp3+ effects. Our research lays foundation for design secure exceptionally potent metal-based agents immunotherapy.

Язык: Английский

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Advances and applications of nanoparticles in cancer therapy

MedComm – Oncology, Год журнала: 2024, Номер 3(1)

Опубликована: Март 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Язык: Английский

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Immunological nanomaterials to combat cancer metastasis

Chemical Society Reviews, Год журнала: 2024, Номер 53(12), С. 6399 - 6444

Опубликована: Янв. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Язык: Английский

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A Multifunctional Covalent Organic Framework Nanozyme for Promoting Ferroptotic Radiotherapy against Esophageal Cancer

ACS Nano, Год журнала: 2023, Номер 17(20), С. 20445 - 20461

Опубликована: Окт. 6, 2023

Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis an iodine- ferrocene-loaded covalent organic framework (COF) nanozyme, termed TADI-COF-Fc, for enhancement radiotherapeutic efficacy in treatment radioresistant esophageal cancer. The iodine atoms on COF not only exerted a direct effect radiotherapy, increasing its X-ray absorption, but also promoted radiolysis water, increased production reactive oxygen species (ROS). In addition, ferrocene surface decoration disrupted redox homeostasis levels hydroxyl lipid peroxide radicals depleting intracellular antioxidants. Both vitro vivo experiments substantiated excellent response TADI-COF-Fc. This study demonstrates potential COF-based multinanozymes as radiosensitizers suggests possible integration strategy combination oncotherapy.

Язык: Английский

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Advancing nanotechnology for neoantigen-based cancer theranostics

Chemical Society Reviews, Год журнала: 2024, Номер 53(7), С. 3224 - 3252

Опубликована: Янв. 1, 2024

Neoantigens play a pivotal role in the field of tumour therapy, encompassing stimulation anti-tumour immune response and enhancement targeting capability. Nonetheless, numerous factors directly influence effectiveness neoantigens bolstering responses, including neoantigen quantity specificity, uptake rates by antigen-presenting cells (APCs), residence duration within microenvironment (TME), their ability to facilitate maturation APCs for activation. Nanotechnology assumes significant several aspects, facilitating release, promoting delivery cells, augmenting dendritic shielding from protease degradation, optimizing interactions between system. Consequently, development nanotechnology synergistically enhances efficacy cancer theranostics. In this review, we provide an overview sources, mechanisms neoantigen-induced evolution precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic other strategies tailored augment therapeutics. We also discuss current challenges prospects application nanomedicine, aiming expedite its clinical translation.

Язык: Английский

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Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics

BMEMat, Год журнала: 2024, Номер unknown

Опубликована: Март 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Язык: Английский

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