European Polymer Journal, Год журнала: 2022, Номер 183, С. 111759 - 111759
Опубликована: Дек. 10, 2022
Язык: Английский
Chemical Society Reviews, Год журнала: 2022, Номер 51(13), С. 5365 - 5451
Опубликована: Янв. 1, 2022
The present review details a chronological description of the events that took place during development mesoporous materials, their different synthetic routes and use as drug delivery systems. outstanding textural properties these materials quickly inspired translation to nanoscale dimension leading silica nanoparticles (MSNs). aspects introducing pharmaceutical agents into pores nanocarriers, together with possible biodistribution clearance routes, would be described here. smart nanocarriers are able release high local concentration therapeutic cargo on-demand after application certain stimuli reviewed here, ability deliver precise locations in body. huge progress design MSNs for biomedical applications, including potential treatment diseases, last 20 years will collated required work still needs done achieve clinical materials. This was conceived stand out from past reports since it aims tell story systems by some makers, who could considered among pioneers this area.
Язык: Английский
Процитировано
272
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Июль 7, 2023
Abstract Over the past several decades, mRNA vaccines have evolved from a theoretical concept to clinical reality. These offer advantages over traditional vaccine techniques, including their high potency, rapid development, low-cost manufacturing, and safe administration. However, until recently, concerns instability inefficient distribution of in vivo limited utility. Fortunately, recent technological advancements mostly resolved these concerns, resulting development numerous vaccination platforms for infectious diseases various types cancer. shown promising outcomes both animal models humans. This study highlights potential as alternative approach conventional techniques cancer treatment. review article aims provide thorough detailed examination vaccines, mechanisms action applications immunotherapy. Additionally, will analyze current state technology highlight future directions implementation this platform mainstream therapeutic option. The also discuss challenges limitations such stability distribution, suggest ways overcome issues. By providing comprehensive overview critical analysis contribute advancement innovative
Язык: Английский
Процитировано
82
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115115 - 115115
Опубликована: Окт. 14, 2023
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They been used many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer, anti-microbial theranostic applications are especially prominent due to their exceptional performance deliver small molecules recently biologics (mRNA, siRNA, antigens, antibodies, proteins, peptides) at targeted sites. The physical chemical properties such as large specific surface area, tuneable particle size porosity, excellent biodegradability biocompatibility make them an ideal delivery diagnostic platform. Based on available data pre-clinical SNP, interest has driven these innovative materials towards clinical application with formulations already Phase I II trials. Herein, progress field is reviewed, safety aspects analysed. Importantly, we critically evaluate key structural characteristics overcome biological barriers blood-brain barrier (BBB), skin, tumour mucosal barrier. Future directions, potential pathways, target areas rapid translation also recommended.
Язык: Английский
Процитировано
78
NPG Asia Materials, Год журнала: 2023, Номер 15(1)
Опубликована: Март 31, 2023
Abstract Nanoarchitectonics describes the integration of nanotechnology with other fields as a postnanotechnology concept that elevates it to material science. Based on this fundamental principle, we address pore-engineered nanoarchitectonics application targets for cancer therapy by combining basic descriptions and exemplifying applications in review. The initial two sections briefly summarize basics according classification based (i) porosity (ii) composition. Afterward, main application-oriented section—designing mesoporous therapy—is presented. Various types drug delivery systems, including nanoparticles nanocarriers, endogenous stimuli-responsive delivery, exogenous targeted are described. Importantly, clinical translation materials is further discussed. Mesoporous unique offer network cavities vehicles nanocarriers. Regarding developments allow be broadly used settings, there several challenges should solved their application. From perspective, tremendous processes development materials.
Язык: Английский
Процитировано
43
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 19, 2024
Abstract Humanity is suffering from cancer which has become a root cause of untimely deaths individuals around the globe in recent past. Nanotheranostics integrates therapeutics and diagnostics to monitor treatment response enhance drug efficacy safety. We hereby propose discuss all imaging diagnostic tools, mechanism targeting tumor cells, current nanotheranostic platforms available for cancer. This review discusses various agents novel molecular tools like MRI, CT, PET, SPEC, PAT used diagnostics. Emphasis given gold nanoparticles, silica, liposomes, dendrimers, metal-based agents. also highlight limitations different field research treatment. Due complexity this area, multifunctional hybrid nanoparticles functionalized with targeted moieties or anti-cancer drugs show best feature theranostics that enables them work on carrying delivering active materials desired area requirement early detection diagnosis. Non-invasive techniques have specificity receptor binding internalization processes nanosystems within cells. may provide appropriate medicine at dose patient time. Graphical abstract
Язык: Английский
Процитировано
37
Chemical Society Reviews, Год журнала: 2024, Номер 53(3), С. 1167 - 1315
Опубликована: Янв. 1, 2024
Silicon-based biomaterials have been extensively developed in the past decades. The classification, characteristics, multi-dimensional design, and biomedical applications of silicon-containing are comprehensively elaborated.
Язык: Английский
Процитировано
29
International Journal of Pharmaceutics, Год журнала: 2022, Номер 625, С. 122099 - 122099
Опубликована: Авг. 10, 2022
Язык: Английский
Процитировано
67
Biomaterials Science, Год журнала: 2022, Номер 10(6), С. 1448 - 1455
Опубликована: Янв. 1, 2022
Mesoporous silica nanoparticles with a noncovalent polymer gatekeeper or protein corona shield are capable of efficient drug loading and targeted delivery.
Язык: Английский
Процитировано
50
Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)
Опубликована: Ноя. 16, 2022
Abstract With the economy's globalization and population's aging, cancer has become leading cause of death in most countries. While imposing a considerable burden on society, high morbidity mortality rates have continuously prompted researchers to develop new oncology treatment options. Anti-tumor regimens evolved from early single surgical combined (or not) chemoradiotherapy then current stage tumor immunotherapy. Tumor immunotherapy undoubtedly pulled some patients back death. However, this strategy activating or boosting body's immune system hardly benefits patients. It is limited by low bioavailability, response rate severe side effects. Thankfully, rapid development nanotechnology broken through bottleneck problem anti-tumor Multifunctional nanomaterials can not only kill tumors combining drugs but also be designed enhance immunity thus achieve multi-treatment effect. worth noting that variety nanomaterials, their modifiability, diversity combinations allow them shine antitumor In paper, several nanobiotics commonly used at are discussed, they activate with unique advantages. conclusion, we reviewed recent advances based such as biological cell membrane modification, self-assembly, mesoporous, metal hydrogels, explore directions strategies for
Язык: Английский
Процитировано
39
MedComm, Год журнала: 2023, Номер 4(2)
Опубликована: Апрель 1, 2023
Abstract Cancer is a disease associated with complex pathology and one of the most prevalent leading reasons for mortality in world. Current chemotherapy has challenges cytotoxicity, selectivity, multidrug resistance, formation stemlike cells. Nanomaterials (NMs) have unique properties that make them useful various diagnostic therapeutic purposes cancer research. NMs can be engineered to target cells early detection deliver drugs directly cells, reducing side effects improving treatment efficacy. Several also used photothermal therapy destroy or enhance immune response by delivering immune‐stimulating molecules modulating tumor microenvironment. are being modified overcome issues, such as toxicity, lack increase drug capacity, bioavailability, wide spectrum therapies. To improve targeted delivery using nano‐carriers, noteworthy research required. metal‐based been studied expectation finding cure treatment. In this review, current development potential plant their on size shape discussed along more effective usage diagnosis
Язык: Английский
Процитировано
38