Regenerative Biomaterials,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 1, 2023
Abstract
Nanoparticles
(NPs)
hold
tremendous
targeting
potential
in
cardiovascular
disease
and
regenerative
medicine,
exciting
clinical
applications
are
coming
into
light.
Vascular
endothelial
cells
(ECs)
exposure
to
different
magnitudes
patterns
of
shear
stress
(SS)
generated
by
blood
flow
could
engulf
NPs
the
blood.
However,
an
unclear
understanding
role
SS
on
NP
uptake
is
hindering
progress
improving
therapies.
Here,
temporal
spatial
distribution
vascular
ECs
effect
highlighted.
The
mechanism
affecting
through
regulating
cellular
ROS
level,
glycocalyx
membrane
fluidity
summarized,
molecules
containing
clathrin
caveolin
engulfment
process
elucidated.
expected
overcome
current
bottlenecks
change
field
nanomedicine.
This
assessment
how
affects
cell
marginalization
vessels
guide
future
research
biology
drugs.
The
nanosystems
for
delivering
drugs
which
have
evolved
with
time,
are
being
designed
greater
drug
efficiency
and
lesser
side-effects,
also
complemented
by
the
advancement
of
numerous
innovative
materials.
In
comparison
to
organic
nanoparticles,
inorganic
nanoparticles
stable,
a
wide
range
physicochemical,
mechanical,
magnetic,
optical
characteristics,
capability
get
modified
using
some
ligands
enrich
their
attraction
towards
molecules
at
target
site,
makes
them
appealing
bio-imaging
delivery
applications.
One
strong
benefits
nanoparticles-drug
conjugate
is
possibility
affected
cells
locally,
thus
reducing
side-effects
like
cytotoxicity,
facilitating
higher
efficacy
therapeutic
drug.
This
review
features
direct
indirect
effects
such
gold,
silver,
graphene-based,
hydroxyapatite,
iron
oxide,
ZnO,
CeO2
in
developing
effective
carrier
systems.
article
has
remarked
peculiarities
these
nanoparticle-based
systems
pulmonary,
ocular,
wound
healing,
antibacterial
deliveries
as
well
across
Blood-Brain-Barrier
(BBB)
acting
agents
cancer
theranostics.
Additionally,
sheds
light
on
plausible
modifications
that
can
be
carried
out
from
researcher's
perspective,
could
open
new
pathway.
Abstract
In
cancer
research
and
personalized
medicine,
mesoporous
silica
nanoparticles
(MSNs)
have
emerged
as
a
significant
breakthrough
in
both
treatment
diagnosis.
MSNs
offer
targeted
drug
delivery,
enhancing
therapeutic
effectiveness
while
minimizing
adverse
effects
on
healthy
cells.
Due
to
their
unique
characteristics,
provide
maximizing
with
minimal
The
review
thoroughly
investigates
the
role
of
potent
carriers,
noted
for
high
drug‐loading
capacity
controlled
release,
which
significantly
improves
permeability
retention.
Additionally,
it
discusses
surface
modification
techniques
that
enable
target
cells
precisely.
manuscript
provides
comprehensive
insights
into
various
MSN
applications,
including
diagnosis,
design
advanced
biosensors,
development
conventional
stimuli‐responsive
delivery
platforms.
Special
focus
is
given
stimuli‐triggered
systems,
responsive
internal
stimuli
(e.g.,
pH,
redox,
enzyme)
external
temperature,
magnetic
field,
light,
ultrasound),
highlighting
cutting‐edge
progress
technology.
delves
immunogenicity
biosafety
aspects
MSNs,
underscoring
potential
clinical
translation.
Besides
summarizing
current
state
oncology,
this
also
illuminates
path
future
advancements
applications.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(44), С. 50953 - 50961
Опубликована: Окт. 26, 2023
Tumor
hypoxia
poses
a
significant
challenge
in
photodynamic
therapy
(PDT),
which
uses
molecular
oxygen
to
produce
reactive
species
upon
light
excitation
of
photosensitizer.
For
mitigation,
an
enzyme
catalase
(CAT)
can
be
beneficially
used
convert
intracellular
hydrogen
peroxide
oxygen,
but
its
utility
is
significantly
limited
due
the
intrinsic
membrane
impermeability.
Herein,
we
present
direct
integration
CAT
into
outer
surface
unmodified
metal-organic
framework
(MOF)
nanoparticles
(NPs)
via
supramolecular
interactions
for
effective
cellular
entry
and
consequent
enhancement
PDT.
The
results
demonstrated
that
CAT-loaded
MOF
NPs
could
successfully
enter
hypoxic
cancer
cells,
after
intracellularly
delivered
molecules
became
dissociated
from
efficiently
initiate
generation
PDT
process
along
with
co-delivered
photosensitizer
IR780.
This
achievement
suggests
our
protein-MOF
strategy
holds
great
potential
biomedical
studies
overcome
tumor
as
well
deliver
biomolecular
cargos.
Micromachines,
Год журнала:
2023,
Номер
14(2), С. 451 - 451
Опубликована: Фев. 15, 2023
The
use
of
gold
nanoparticles
as
drug
delivery
systems
has
received
increasing
attention
due
to
their
unique
properties,
such
high
stability
and
biocompatibility.
However,
have
a
affinity
for
proteins,
which
can
result
in
rapid
clearance
from
the
body
limited
loading
capabilities.
To
address
these
limitations,
we
coated
with
silica
PEG,
are
known
improve
nanoparticles.
synthesis
was
carried
out
using
reduction
method.
nanoparticles’
size,
morphology,
capacity
were
also
studied.
SEM
images
showed
spherical
homogeneous
morphology;
they
that
coatings
increased
average
size
results
this
study
provide
insight
into
potential
PEG
systems.
We
used
ibuprofen
model
found
highest
load
occurred
PEG-coated
then
silica-coated
nanoparticles,
while
uncoated
had
lower
capacity.
significantly
properties
making
them
promising
candidates
further
development
targeted
controlled
release
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Март 29, 2023
Abstract
Malignant
gliomas
are
a
type
of
primary
brain
tumour
that
originates
in
glial
cells.
Among
them,
glioblastoma
multiforme
(GBM)
is
the
most
common
and
aggressive
adults,
classified
as
grade
IV
by
World
Health
Organization.
The
standard
care
for
GBM,
known
Stupp
protocol
includes
surgical
resection
followed
oral
chemotherapy
with
temozolomide
(TMZ).
This
treatment
option
provides
median
survival
prognosis
only
16–18
months
to
patients
mainly
due
recurrence.
Therefore,
enhanced
options
urgently
needed
this
disease.
Here
we
show
development,
characterization,
vitro
vivo
evaluation
new
composite
material
local
therapy
GBM
post-surgery.
We
developed
responsive
nanoparticles
were
loaded
paclitaxel
(PTX),
showed
penetration
3D
spheroids
cell
internalization.
These
found
be
cytotoxic
2D
(U-87
cells)
spheroids)
models
GBM.
incorporation
these
into
hydrogel
facilitates
their
sustained
release
time.
Moreover,
formulation
containing
PTX-loaded
free
TMZ
was
able
delay
recurrence
after
surgery.
our
represents
promising
approach
develop
combined
therapies
against
using
injectable
hydrogels
nanoparticles.
Abstract
Bacteria
extracellular
vesicles
(BEVs),
characterized
as
the
lipid
bilayer
membrane-surrounded
nanoparticles
filled
with
molecular
cargo
from
parent
cells,
play
fundamental
roles
in
bacteria
growth
and
pathogenesis,
well
facilitating
essential
interaction
between
host
systems.
Notably,
benefiting
their
unique
biological
functions,
BEVs
hold
great
promise
novel
nanopharmaceuticals
for
diverse
biomedical
potential,
attracting
significant
interest
both
industry
academia.
Typically,
are
evaluated
promising
drug
delivery
platforms,
on
account
of
intrinsic
cell-targeting
capability,
ease
versatile
engineering,
capability
to
penetrate
physiological
barriers.
Moreover,
attributing
considerable
immunogenicity,
able
interact
immune
system
boost
immunotherapy
nanovaccine
against
a
wide
range
diseases.
Towards
these
directions,
this
review,
we
elucidate
nature
role
activating
response
better
understanding
BEV-based
nanopharmaceuticals’
development.
Additionally,
also
systematically
summarize
recent
advances
achieving
target
genetic
material,
therapeutic
agents,
functional
materials.
Furthermore,
vaccination
strategies
using
carefully
covered,
illustrating
flexible
potential
combating
bacterial
infections,
viral
cancer.
Finally,
current
hurdles
further
outlook
will
be
provided.
Graphical
Journal of Applied Biomaterials & Functional Materials,
Год журнала:
2025,
Номер
23
Опубликована: Янв. 1, 2025
In
this
study,
biocomposite
membranes
were
developed
by
incorporating
resveratrol
(RSV)-loaded
PCL-PEG
composites,
modified
with
graphene
oxide
(GO)
and
hydroxyapatite
(HAP).
The
aim
was
to
enhance
hydrophilicity
GO
improve
bioactivity
HAP.
release
kinetics
of
RSV
evaluated
using
Franz
diffusion
cells
compared
various
kinetic
models,
including
Korsmeyer-Peppas,
Higuchi,
Baker,
all
which
showed
high
correlation
coefficients
(
R²)
close
0.99.
Mechanical
tests
performed
determine
the
suitability
these
for
tissue
engineering
applications.
composite
membrane
HAP
exhibited
tensile
strength
105.2
±
5.8
MPa,
modulus
3895
159
elongation
at
break
8.4
0.9%,
toughness
5.88
0.46
MJ/m³.
vitro
cell
adhesion
studies,
visualized
DAPI
fluorescence
staining,
demonstrated
increased
over
periods
1,
3,
5,
7,
14
days.
These
findings
highlight
potential
RSV-loaded
membranes,
enhanced
HAP,
applications
in
bone
engineering.
Polymers,
Год журнала:
2025,
Номер
17(7), С. 833 - 833
Опубликована: Март 21, 2025
Polymeric
nanoparticles
(PNPs)
represent
a
groundbreaking
advancement
in
targeted
drug
delivery,
offering
significant
benefits
over
conventional
systems.
This
includes
their
versatility,
biocompatibility,
and
ability
to
encapsulate
diverse
therapeutic
agents
provide
controlled
release,
improving
efficacy
while
minimizing
side
effects.
The
polymers
used
PNP
formulations
are
critical,
as
they
influence
the
nanoparticles'
physicochemical
properties
such
size,
shape,
surface
charge,
drug-loading
capacity.
Recent
developments
polymer
chemistry
nanotechnology
have
led
creation
of
smart
PNPs
that
can
respond
specific
stimuli,
enabling
precise
release
environments.
review
explores
mechanisms
innovations
polymeric
formulations,
fabrication
characterization
techniques
enhance
delivery
Additionally,
it
discusses
challenges
future
directions
field,
highlighting
potential
for
personalized
medicine
role
artificial
intelligence
optimizing
nanoparticle
design.
By
examining
relationship
between
characteristics
performance,
aims
promote
innovative
strategies
modern
medicine.
Despite
promise
polymer-based
systems,
toxicity,
stability,
scalability,
regulatory
compliance
must
be
addressed.
Future
research
should
focus
on
rigorous
testing,
clear
risk
communication,
sustainable
practices
support
clinical
translation
commercial
viability.
Overall,
integration
these
elements
is
crucial
advancing
applications.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 31, 2025
Abstract
Background
Breast
cancer
remains
one
of
the
leading
causes
death
among
women
globally,
with
traditional
therapies
often
limited
by
challenges
such
as
drug
resistance
and
significant
side
effects.
Combination
therapies,
coupled
nanotechnology-based
co-delivery
systems,
offer
enhanced
efficacy
targeting
multiple
pathways
in
progression.
In
this
study,
we
developed
an
injectable,
stimuli-responsive
nanosystem
using
a
chitosan
hydrogel
embedded
mesoporous
silica
nanoparticles
for
co-administration
5-fluorouracil
everolimus.
This
approach
aims
to
optimize
controlled
release,
enhance
synergistic
anticancer
effect,
overcome
associated
co-loading
different
therapeutic
agents.
Methods
Various
techniques
were
employed
characterize
hydrogel.
Cell
uptake,
apoptosis,
proliferation
4T1
breast
cells
evaluated
flow
cytometry
Resazurin
assay,
respectively.
The
Balb/C
mice
model
cancer,
which
received
therapeutical
nanoplatforms
subcutaneously
near
tumoral
region
was
used
examine
tumor
size
lung
metastases.
Results
results
revealed
that
had
suitable
loading
capacity
high
cellular
uptake.
release
pH-sensitive
synergistic.
By
incorporating
into
hydrogel,
cell
rate
apoptosis
increased
significantly,
due
effects
co-delivered
drugs.
Additionally,
combination
treatment
groups
showed
reduction
metastasis
compared
monotherapy
control
groups.
Conclusions
These
findings
underscore
potential
nanocomposite
develop
novel
system
outcomes,
reduce
effects,
provide
promising
new
strategy
future
treatments.
