Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июнь 8, 2023
Extracellular
vesicles
(EVs)
have
emerged
as
a
promising
platform
for
gene
delivery
owing
to
their
natural
properties
and
phenomenal
functions,
being
able
circumvent
the
significant
challenges
associated
with
toxicity,
problematic
biocompatibility,
immunogenicity
of
standard
approaches.
These
features
are
particularly
interest
targeted
emerging
clustered
regularly
interspaced
short
palindromic
repeat
(CRISPR)/CRISPR-associated
(Cas)
systems.
However,
current
efficiency
EV-meditated
transport
CRISPR/Cas
components
remains
insufficient
due
numerous
exogenous
endogenous
barriers.
Here,
we
comprehensively
reviewed
status
EV-based
In
particular,
explored
various
strategies
methodologies
available
potentially
improve
loading
capacity,
safety,
stability,
targeting,
tracking
system
delivery.
Additionally,
hypothesise
future
avenues
development
systems
that
could
pave
way
novel
clinically
valuable
approaches,
may
bridge
gap
between
editing
technologies
laboratory/clinical
application
therapies.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 615 - 615
Опубликована: Фев. 11, 2023
Poly(lactic-co-glycolic
acid)
(PLGA)
particles
are
a
widely
used
and
extensively
studied
drug
delivery
system.
The
favorable
properties
of
PLGA
such
as
good
bioavailability,
controlled
release,
an
excellent
safety
profile
due
to
the
biodegradable
polymer
backbone
qualified
for
approval
by
authorities
application
platform
in
humas.
In
recent
years,
immunotherapy
has
been
established
potent
treatment
option
variety
diseases.
However,
immunomodulating
drugs
rely
on
targeted
specific
immune
cell
subsets
often
rapidly
eliminated
from
Loading
with
can
protect
therapeutic
compounds
premature
degradation,
direct
tissues
or
cells,
ensure
sustained
release.
These
present
ideal
immunotherapy.
Here,
we
review
advances
particulate
systems
fields
allergy,
autoimmunity,
infectious
diseases,
cancer.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Effective
management
of
serious
respiratory
diseases,
such
as
asthma
and
recalcitrant
rhinitis,
remains
a
global
challenge.
Here,
it
is
shown
that
induced
sputum
supernatants
(ISS)
from
patients
with
contain
higher
levels
cell-free
DNA
(cfDNA)
compared
to
healthy
volunteers.
Although
cfDNA
scavenging
strategies
have
been
developed
for
inflammation
modulation
in
previous
studies,
this
fall
short
clinical
settings
due
the
excessive
neutrophil
extracellular
trap
(NET)
formation,
reactive
oxygen
nitrogen
species
(RONS)
bacterial
infections
injured
airway
tissues.
Based
on
this,
multifunctional
boron-based
2D
nanoplatform
B-PM
designed
by
coating
boron
nanosheets
(B-NS)
polyamidoamine
generation
1
(PG1)
dendrimer,
which
can
simultaneously
target
cfDNA,
NETs,
RONS,
bacteria.
The
effects
promoting
mucosal
repair,
reducing
inflammation,
mucus
production
demonstrated
model
mice,
therapeutic
effect
superior
dexamethasone.
Furthermore,
flow
cytometry
clustering
analysis
transcriptome
RNA-sequencing
are
adopted
comprehensively
evaluate
vivo
anti-inflammation
effects.
These
findings
emphasize
significance
multi-targeting
strategy
modulate
dysregulated
highlight
nanoplatforms
amelioration
inflammatory
diseases.
Pharmacological Research,
Год журнала:
2023,
Номер
199, С. 107022 - 107022
Опубликована: Дек. 1, 2023
Macrophages,
as
highly
phenotypic
plastic
immune
cells,
play
diverse
roles
in
different
pathological
conditions.
Changing
and
controlling
the
phenotypes
of
macrophages
is
considered
a
novel
potential
therapeutic
intervention.
Meanwhile,
specific
transmembrane
proteins
anchoring
on
surface
macrophage
membrane
are
relatively
conserved,
supporting
its
functional
properties,
such
inflammatory
chemotaxis
tumor
targeting.
Thus,
series
drug
delivery
systems
related
to
commonly
used
treat
chronic
diseases.
This
review
summarizes
macrophages-based
strategies
for
diseases,
discusses
regulation
their
polarization
processes,
presents
how
design
apply
site-specific
targeted
vivo
based
derived
receptors.
It
aims
provide
better
understanding
immunoregulation
proposes
approaches
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(5), С. 2039 - 2056
Опубликована: Янв. 27, 2024
Osteosarcoma,
a
prevalent
primary
malignant
bone
tumor,
often
presents
with
lung
metastases,
severely
impacting
patient
survival
rates.
Extracellular
vesicles,
particularly
exosomes,
play
pivotal
role
in
the
formation
and
progression
of
osteosarcoma-related
pulmonary
lesions.
However,
communication
between
osteosarcoma
exosome-mediated
lesions
remains
obscure,
potential
impact
metastatic
foci
on
largely
unknown.
This
study
unveils
an
innovative
mechanism
by
which
exosomes
originating
from
sites
transport
miR-194/215
cluster
to
tumor
site.
transportation
enhances
capability
downregulating
myristoylated
alanine-rich
C-kinase
substrate
(MARCKS)
expression.
Addressing
this
phenomenon,
we
employ
cationic
bovine
serum
albumin
(CBSA)
form
nanoparticles
(CBSA-anta-194/215)
via
electrostatic
interaction
antagomir-miR-194/215.
These
are
loaded
into
nucleic
acid-depleted
exosomal
membrane
vesicles
(anta-194/215@Exo)
targeting
sites.
Intervention
bioengineered
exosome
mimetics
not
only
impedes
but
also
significantly
prolongs
lifespan
tumor-bearing
mice.
findings
suggest
that
foci-derived
initiate
metastasis
transferring
MARCKS,
making
promising
therapeutic
target
for
inhibiting
patients
metastases.
Abstract
Inflammation‐associated
diseases
are
very
common
clinically
with
a
high
incidence;
however,
there
is
still
lack
of
effective
treatments.
Cell‐biomimetic
nanoplatforms
have
led
to
many
breakthroughs
in
the
field
biomedicine,
significantly
improving
efficiency
drug
delivery
and
its
therapeutic
implications
especially
for
inflammation‐associated
diseases.
Macrophages
an
important
component
immune
cells
play
critical
role
occurrence
progression
while
simultaneously
maintaining
homeostasis
modulating
responses.
Therefore,
macrophage‐biomimetic
not
only
inherit
functions
macrophages
including
inflammation
tropism
effect
targeted
drugs
neutralization
pro‐inflammatory
cytokines
toxins
via
membrane
surface
receptors
or
proteins,
but
also
maintain
inner
nanoparticles.
Macrophage‐biomimetic
shown
remarkable
efficacy
excellent
application
potential
In
this
review,
diseases,
physiological
macrophages,
classification
construction
first
introduced.
Next,
latest
applications
different
treatment
summarized.
Finally,
challenges
opportunities
future
biomedical
discussed.
It
hoped
that
review
will
provide
new
ideas
further
development
nanoplatforms.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1899 - 1899
Опубликована: Июль 6, 2023
Recent
studies
have
revealed
the
functional
roles
of
cell
membrane
coated-nanoparticles
(CMNPs)
in
tackling
urological
diseases,
including
cancers,
inflammation,
and
acute
kidney
injury.
Cells
are
a
fundamental
part
pathology
to
regulate
nearly
all
and,
therefore,
naturally
derived
membranes
inherit
role
enhance
biopharmaceutical
performance
their
encapsulated
nanoparticles
on
drug
delivery.
In
this
review,
methods
for
CMNP
synthesis
surface
engineering
summarized.
The
application
different
types
CMNPs
diseases
is
updated,
cancer
membrane,
stem
immune
erythrocytes
membranes,
extracellular
vesicles,
potential
clinical
use
discussed.
