ACS Omega,
Год журнала:
2024,
Номер
9(10), С. 11608 - 11614
Опубликована: Фев. 28, 2024
With
the
emergence
of
SARS-CoV-2
and
continued
new
infectious
diseases,
there
is
a
need
to
improve
expand
current
vaccine
technology.
Controlled-release
subunit
vaccines
provide
several
benefits
over
on
market,
including
use
less
antigen
fewer
boost
doses.
Previously,
our
group
reported
molecules
that
alter
NF-κB
signaling
improved
vaccine's
performance
adjuvant-related
tolerability.
In
this
report,
we
test
how
these
immune
potentiators
will
influence
responses
when
included
as
part
controlled-release
poly(lactic-co-glycolic)
formulation.
Murine
in
vivo
studies
revealed
SN50
honokiol
antibody
levels
at
early
time
points.
Microparticles
with
produced
strong
longer
period
compared
microparticles
without
SN50.
The
same
particles
also
increased
T-cell
activity.
All
tested
further
promoted
Th2
humoral
already
exhibited
by
control
CpG
OVA
microparticle
Overall,
under
conditions,
enhance
existing
effects
formulations,
making
it
potentially
beneficial
additive
for
formulations.
Tumor
immunotherapy,
which
utilizes
the
immune
system
to
fight
cancer,
represents
a
revolutionary
method
for
cancer
treatment.
Poly
(lactic-co-glycolic
acid)
(PLGA)
copolymer
has
emerged
as
promising
material
tumor
immunotherapy
due
its
biocompatibility,
biodegradability,
and
versatility
in
drug
delivery.
By
tuning
size,
shape,
surface
properties
of
PLGA-based
systems,
researchers
have
improved
their
ability
align
with
requirements
diverse
modalities.
In
this
review,
basic
PLGA
materials
are
first
introduced
further
principal
forms
systems
controlled
release
summarized
delivery
applications
targeted.
addition,
recent
advances
use
highlighted
enhance
antitumor
responses
terms
vaccines,
immunogenic
cell
death-mediated
responses,
microenvironment
modulation,
combination
immunotherapies.
Finally,
prospects
future
research
clinical
translation
proposed.
Abstract
The
field
of
immunotherapeutics
is
rapidly
evolving
with
the
advent
cell
therapies,
complex
biologics,
and
a
host
other
compounds.
Polymeric
carriers
are
often
used
to
tune
safety
efficacy
profiles
these
novel
drugs.
Despite
their
prevalence
in
pre‐clinical
clinical
applications,
non‐degradable
materials
present
delivery
challenges
including
diffusion‐limited
release,
frustrated
phagocytosis,
limited
clearance.
In
contrast,
biodegradable
polymeric
systems
provide
safer
alternative
addition
displaying
advantageous
properties
for
immunotherapies.
this
review,
discussion
polymers
poly(lactic‐co‐glycolic
acid)
(PLGA),
poly(beta‐amino
esters)
(PBAEs),
acetalated
dextran
(Ace‐DEX),
chitosan,
alginate,
hyaluronic
acid
(HA)
as
immunomodulatory
biomaterial
suggest
that
variety
can
be
generate
tailored
formulations
different
therapeutic
payloads
disease
indications.
These
carrier
enhance
immunotherapies
via
tunable
degradation
rates,
enhanced
antigen‐presentation,
inherent
biomaterials,
among
mechanisms.
Polymers
formulated
applications
synthetic,
semi‐synthetic,
or
naturally
derived.
Therefore,
it
crucial
consider
environmental
impact
polymer
sources,
particle
fabrication
methods,
solvent
usage
sustainably
develop
effective
therapies
field.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1772 - 1772
Опубликована: Июнь 20, 2023
Chronic
inflammation
contributes
to
the
pathogenesis
of
many
diseases,
including
apparently
unrelated
conditions
such
as
metabolic
disorders,
cardiovascular
neurodegenerative
osteoporosis,
and
tumors,
but
use
conventional
anti-inflammatory
drugs
treat
these
diseases
is
generally
not
very
effective
given
their
adverse
effects.
In
addition,
some
alternative
medications,
natural
compounds,
have
scarce
solubility
stability,
which
are
associated
with
low
bioavailability.
Therefore,
encapsulation
within
nanoparticles
(NPs)
may
represent
an
strategy
enhance
pharmacological
properties
bioactive
molecules,
poly
lactic-co-glycolic
acid
(PLGA)
NPs
been
widely
used
because
high
biocompatibility
biodegradability
possibility
finely
tune
erosion
time,
hydrophilic/hydrophobic
nature,
mechanical
by
acting
on
polymer's
composition
preparation
technique.
Many
studies
focused
PLGA-NPs
deliver
immunosuppressive
treatments
for
autoimmune
allergic
or
elicit
protective
immune
responses,
in
vaccination
cancer
immunotherapy.
By
contrast,
this
review
PLGA
preclinical
vivo
models
other
a
key
role
played
chronic
unbalance
between
reparative
phases
inflammation,
particular
focus
intestinal
bowel
disease;
cardiovascular,
neurodegenerative,
osteoarticular,
ocular
diseases;
wound
healing.
Annual Review of Biomedical Engineering,
Год журнала:
2024,
Номер
26(1), С. 273 - 306
Опубликована: Июль 3, 2024
Nanomaterials
are
becoming
important
tools
for
vaccine
development
owing
to
their
tunable
and
adaptable
nature.
Unique
properties
of
nanomaterials
afford
opportunities
modulate
trafficking
through
various
tissues,
complement
or
augment
adjuvant
activities,
specify
antigen
valency
display.
This
versatility
has
enabled
recent
work
designing
nanomaterial
vaccines
a
broad
range
diseases,
including
cancer,
inflammatory
infectious
diseases.
Recent
successes
nanoparticle
during
the
coronavirus
disease
2019
(COVID-19)
pandemic
have
fueled
enthusiasm
further.
In
this
review,
most
developments
in
nanovaccines
disease,
allergic
nanoadjuvants
summarized.
Additionally,
challenges
clinical
translation
unique
class
materials
discussed.
Biomolecules,
Год журнала:
2024,
Номер
14(8), С. 1036 - 1036
Опубликована: Авг. 20, 2024
The
development
of
vaccines
has
entered
a
new
era
with
the
advent
nanotechnology,
particularly
through
utilization
nanoparticles.
This
review
focuses
on
role
nanoparticles
in
enhancing
efficacy
and
stability
mRNA
vaccines.
Nanoparticles,
owing
to
their
unique
properties
such
as
high
surface
area,
tunable
size,
ability
be
functionalized,
have
emerged
powerful
tools
vaccine
development.
Specifically,
lipid
(LNPs)
revolutionized
delivery
by
protecting
fragile
molecules
facilitating
efficient
uptake
cells.
discusses
various
types
employed
formulations,
including
lipid-based,
polymer-based,
inorganic
nanoparticles,
highlighting
advantages
limitations.
Moreover,
it
explores
mechanisms
which
improve
immune
responses,
enhanced
antigen
presentation
prolonged
release
mRNA.
also
addresses
challenges
future
directions
nanoparticle-based
development,
emphasizing
need
for
further
research
optimize
formulations
broader
applications.
By
providing
an
in-depth
analysis
current
advancements
potential
vaccines,
this
aims
shed
light
critical
combating
infectious
diseases
improving
public
health
outcomes.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 12, 2024
Biomaterials
are
substances
that
can
be
injected,
implanted,
or
applied
to
the
surface
of
tissues
in
biomedical
applications
and
have
ability
interact
with
biological
systems
initiate
therapeutic
responses.
Biomaterial-based
vaccine
delivery
possess
robust
packaging
capabilities,
enabling
sustained
localized
drug
release
at
target
site.
Throughout
process,
they
contribute
protecting,
stabilizing,
guiding
immunogen
while
also
serving
as
adjuvants
enhance
efficacy.
In
this
article,
we
provide
a
comprehensive
review
contributions
biomaterials
advancement
development.
We
begin
by
categorizing
biomaterial
types
properties,
detailing
their
reprocessing
strategies,
exploring
several
common
systems,
such
polymeric
nanoparticles,
lipid
hydrogels,
microneedles.
Additionally,
investigated
how
physicochemical
properties
routes
influence
immune
Notably,
delve
into
design
considerations
adjuvants,
showcasing
application
development
for
cancer,
acquired
immunodeficiency
syndrome,
influenza,
corona
virus
disease
2019
(COVID-19),
tuberculosis,
malaria,
hepatitis
B.
review,
highlight
successful
instances
where
enhanced
efficacy
discuss
limitations
future
directions
immunotherapy.
This
aims
offer
researchers
understanding
stimulate
further
progress
related
fields.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Окт. 9, 2023
Dendritic
cells
(DCs)
are
the
major
specialized
antigen-presenting
(APCs),
play
a
key
role
in
initiating
body’s
immune
response,
maintain
balance
of
immunity.
DCs
can
also
induce
tolerance
by
rendering
effector
T
absent
and
anergy,
promoting
expansion
regulatory
cells.
Induction
tolerogenic
has
been
proved
to
be
promising
strategy
for
treatment
autoimmune
diseases,
organ
transplantation,
allergic
diseases
various
laboratory
researches
clinical
trials.
The
development
nano-delivery
systems
led
advances
situ
modulation
phenotype
DCs.
By
changing
material
composition,
particle
size,
zeta-potential,
surface
modification
nanoparticles,
nanoparticles
used
therapeutic
payloads
targeted
delivery
DCs,
endowing
them
with
great
potential
induction
tolerance.
This
paper
reviews
how
modulated
their
diseases.
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
14(10), С. 2788 - 2803
Опубликована: Март 1, 2024
Melanoma
is
the
main
cause
of
death
among
skin
cancers
and
its
incidence
worldwide
has
been
experiencing
an
appalling
increase.
However,
traditional
treatments
lack
effectiveness
in
advanced
or
metastatic
patients.
Immunotherapy,
meanwhile,
shown
to
be
effective
treatment
option,
but
rate
responding
remains
far
from
ideal.
Here
we
have
developed
a
personalized
neoantigen
peptide-based
cancer
vaccine
by
encapsulating
patient
derived
melanoma
neoantigens
polyethylenimine
(PEI)-functionalised
poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs)
coating
them
with
polyinosinic:polycytidylic
acid
(poly(I:C)).
We
found
that
PLGA
NPs
can
effectively
modified
coated
immunoadjuvant
poly(I:C),
as
well
encapsulate
neoantigens.
In
addition,
both
dendritic
cells
(DCs)
lymphocytes
were
stimulated.
Moreover,
NP
was
better
immune
activation
profile
than
without
poly(I:C)
antigen.
Our
results
demonstrate
high
capacity
activate
system,
efficiently
maturing
DCs
present
antigen
choice
promoting
activity
exert
their
cytotoxic
function.
Therefore,
response
generated
optimal
specific
for
elimination
tumour
cells.
