Engineered Extracellular Vesicles: A potential treatment for regeneration DOI Creative Commons
Wen‐Chih Cheng, Chenyu Xu, Yuran Su

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(11), P. 108282 - 108282

Published: Oct. 24, 2023

Extracellular vesicles (EVs) play a critical role in various physiological and pathological processes. EVs have gained recognition regenerative medicine due to their biocompatibility low immunogenicity. However, the practical application of faces challenges such as limited targeting ability, yield, inadequate therapeutic effects. To overcome these limitations, engineered emerged. This review aims comprehensively analyze engineering methods utilized for modifying donor cells EVs, with focus on comparing potential between natural EVs. Additionally, it investigate specific cell effects that crucial promoting repair regeneration, while also exploring underlying mechanisms involved field medicine.

Language: Английский

PLGA Particles in Immunotherapy DOI Creative Commons
Dennis J. Horvath, Michael Basler

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 615 - 615

Published: Feb. 11, 2023

Poly(lactic-co-glycolic acid) (PLGA) particles are a widely used and extensively studied drug delivery system. The favorable properties of PLGA such as good bioavailability, controlled release, an excellent safety profile due to the biodegradable polymer backbone qualified for approval by authorities application platform in humas. In recent years, immunotherapy has been established potent treatment option variety diseases. However, immunomodulating drugs rely on targeted specific immune cell subsets often rapidly eliminated from Loading with can protect therapeutic compounds premature degradation, direct tissues or cells, ensure sustained release. These present ideal immunotherapy. Here, we review advances particulate systems fields allergy, autoimmunity, infectious diseases, cancer.

Language: Английский

Citations

29
Airway epithelial-targeted nanoparticle reverses asthma in inhalation therapy DOI

Yinglan Yu,

Mingjie Ni,

Yaxian Zheng

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 223 - 234

Published: Jan. 26, 2024

Language: Английский

Citations

11
Biomimetic nanoparticles with cell-membrane camouflage for rheumatoid arthritis DOI Creative Commons
Jingjing Gan, Danqing Huang,

Junyi Che

et al.

Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 794 - 825

Published: Jan. 15, 2024

Language: Английский

Citations

9
Multifunctional Boron‐based 2D Nanoplatforms Ameliorate Severe Respiratory Inflammation by Targeting Multiple Inflammatory Mediators DOI Creative Commons
Changyi Xu,

Ming Liu,

Xinran Xie

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Effective management of serious respiratory diseases, such as asthma and recalcitrant rhinitis, remains a global challenge. Here, it is shown that induced sputum supernatants (ISS) from patients with contain higher levels cell-free DNA (cfDNA) compared to healthy volunteers. Although cfDNA scavenging strategies have been developed for inflammation modulation in previous studies, this fall short clinical settings due the excessive neutrophil extracellular trap (NET) formation, reactive oxygen nitrogen species (RONS) bacterial infections injured airway tissues. Based on this, multifunctional boron-based 2D nanoplatform B-PM designed by coating boron nanosheets (B-NS) polyamidoamine generation 1 (PG1) dendrimer, which can simultaneously target cfDNA, NETs, RONS, bacteria. The effects promoting mucosal repair, reducing inflammation, mucus production demonstrated model mice, therapeutic effect superior dexamethasone. Furthermore, flow cytometry clustering analysis transcriptome RNA-sequencing are adopted comprehensively evaluate vivo anti-inflammation effects. These findings emphasize significance multi-targeting strategy modulate dysregulated highlight nanoplatforms amelioration inflammatory diseases.

Language: Английский

Citations

1
Treatment of food allergy DOI
Sayantani Sindher,

Claire Hillier,

Brent W. Anderson

et al.

Annals of Allergy Asthma & Immunology, Journal Year: 2023, Volume and Issue: 131(1), P. 29 - 36

Published: April 25, 2023

Language: Английский

Citations

18
Macrophage-related therapeutic strategies: Regulation of phenotypic switching and construction of drug delivery systems DOI Creative Commons
Xi Wang, Yixuan Li,

Xueyu Pu

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107022 - 107022

Published: Dec. 1, 2023

Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different pathological conditions. Changing and controlling the phenotypes of macrophages is considered a novel potential therapeutic intervention. Meanwhile, specific transmembrane proteins anchoring on surface macrophage membrane are relatively conserved, supporting its functional properties, such inflammatory chemotaxis tumor targeting. Thus, series drug delivery systems related to commonly used treat chronic diseases. This review summarizes macrophages-based strategies for diseases, discusses regulation their polarization processes, presents how design apply site-specific targeted vivo based derived receptors. It aims provide better understanding immunoregulation proposes approaches

Language: Английский

Citations

18
Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS DOI Creative Commons

Pei Yu,

Yubao Han,

Lulu Meng

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2039 - 2056

Published: Jan. 27, 2024

Osteosarcoma, a prevalent primary malignant bone tumor, often presents with lung metastases, severely impacting patient survival rates. Extracellular vesicles, particularly exosomes, play pivotal role in the formation and progression of osteosarcoma-related pulmonary lesions. However, communication between osteosarcoma exosome-mediated lesions remains obscure, potential impact metastatic foci on largely unknown. This study unveils an innovative mechanism by which exosomes originating from sites transport miR-194/215 cluster to tumor site. transportation enhances capability downregulating myristoylated alanine-rich C-kinase substrate (MARCKS) expression. Addressing this phenomenon, we employ cationic bovine serum albumin (CBSA) form nanoparticles (CBSA-anta-194/215) via electrostatic interaction antagomir-miR-194/215. These are loaded into nucleic acid-depleted exosomal membrane vesicles (anta-194/215@Exo) targeting sites. Intervention bioengineered exosome mimetics not only impedes but also significantly prolongs lifespan tumor-bearing mice. findings suggest that foci-derived initiate metastasis transferring MARCKS, making promising therapeutic target for inhibiting patients metastases.

Language: Английский

Citations

8
Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair DOI

Tianjing Sun,

Mo Li,

Qi Liu

et al.

Frontiers of Medicine, Journal Year: 2024, Volume and Issue: 18(2), P. 258 - 284

Published: Jan. 13, 2024

Language: Английский

Citations

6
Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment DOI
Mengjun Zhang,

Huiyang Jiang,

Lan Wu

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 422 - 437

Published: Oct. 31, 2022

Language: Английский

Citations

23
Macrophage‐Biomimetic Nanoplatform‐Based Therapy for Inflammation‐Associated Diseases DOI
Ying Qu, Bingyang Chu, Jianan Li

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 8(7)

Published: Nov. 30, 2023

Abstract Inflammation‐associated diseases are very common clinically with a high incidence; however, there is still lack of effective treatments. Cell‐biomimetic nanoplatforms have led to many breakthroughs in the field biomedicine, significantly improving efficiency drug delivery and its therapeutic implications especially for inflammation‐associated diseases. Macrophages an important component immune cells play critical role occurrence progression while simultaneously maintaining homeostasis modulating responses. Therefore, macrophage‐biomimetic not only inherit functions macrophages including inflammation tropism effect targeted drugs neutralization pro‐inflammatory cytokines toxins via membrane surface receptors or proteins, but also maintain inner nanoparticles. Macrophage‐biomimetic shown remarkable efficacy excellent application potential In this review, diseases, physiological macrophages, classification construction first introduced. Next, latest applications different treatment summarized. Finally, challenges opportunities future biomedical discussed. It hoped that review will provide new ideas further development nanoplatforms.

Language: Английский

Citations

16