Nanoparticles: Taking a Unique Position in Medicine

Nanomaterials, Год журнала: 2023, Номер 13(3), С. 574 - 574

Опубликована: Янв. 31, 2023

The human nature of curiosity, wonder, and ingenuity date back to the age humankind. In parallel with our history civilization, interest in scientific approaches unravel mechanisms underlying natural phenomena has been developing. Recent years have witnessed unprecedented growth research area pharmaceuticals medicine. optimism that nanotechnology (NT) applied medicine drugs is taking serious steps bring about significant advances diagnosing, treating, preventing disease-a shift from fantasy reality. growing future medical applications NT leads emergence a new field for nanomaterials (NMs) biomedicine. recent years, NMs emerged as essential game players modern medicine, clinical ranging contrast agents imaging carriers drug gene delivery into tumors. Indeed, there are instances where nanoparticles (NPs) enable analyses therapies cannot be performed otherwise. However, NPs also unique environmental societal challenges, particularly concerning toxicity. Thus, should revisited, deep understanding effects pathophysiologic basis disease may more sophisticated diagnostic opportunities yield effective preventive features. Correspondingly, this review highlights contributions systems. This study attempted glimpse impact pharmaceuticals.

Язык: Английский

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Recent advances in point of care testing for COVID-19 detection

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 153, С. 113538 - 113538

Опубликована: Авг. 12, 2022

The World Health Organizations declaration of the COVID-19 pandemic was a milestone for scientific community. high transmission rate and huge number deaths, along with lack knowledge about virus evolution disease, stimulated relentless search diagnostic tests, treatments, vaccines. main challenges were differential diagnosis development specific, rapid, sensitive tests that could reach all people. RT-PCR remains gold standard diagnosing COVID-19. However, new methods, such as other molecular techniques immunoassays emerged. Also, need accessible quick results boosted point care (POCT) are fast, automated, precision accuracy. This assay reduces dependence on laboratory conditions mass testing population, dispersing pressure regarding screening detection. review summarizes advances in field since started, emphasizing various detecting We reviewed existing well POCT under development, starting detection, but also exploring nucleic acid techniques, digital PCR, loop-mediated isothermal amplification-based (RT-LAMP), clustered regularly interspaced short palindromic repeats (CRISPR), next-generation sequencing (NGS), immunoassay nanoparticle-based biosensors, developed portable instruments rapid

Язык: Английский

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New insights from nanotechnology in SARS-CoV-2 detection, treatment strategy, and prevention

Materials Today Chemistry, Год журнала: 2023, Номер 29, С. 101478 - 101478

Опубликована: Март 3, 2023

Язык: Английский

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Interface‐Engineered Field‐Effect Transistor Electronic Devices for Biosensing

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Дек. 4, 2023

Promising advances in molecular medicine have promoted the urgent requirement for reliable and sensitive diagnostic tools. Electronic biosensing devices based on field-effect transistors (FETs) exhibit a wide range of benefits, including rapid label-free detection, high sensitivity, easy operation, capability integration, possessing significant potential application disease screening health monitoring. In this perspective, tremendous efforts achievements development high-performance FET biosensors past decade are summarized, with emphasis interface engineering FET-based electrical platforms biomolecule identification. First, an overview strategies modulation recognition element design is discussed detail. For further step, applications vitro detection real-time monitoring biological systems comprehensively reviewed. Finally, key opportunities challenges electronic discussed. It anticipated that comprehensive understanding will inspire additional techniques developing highly sensitive, specific, stable as well emerging designs next-generation electronics.

Язык: Английский

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Opportunities and Challenges for Inhalable Nanomedicine Formulations in Respiratory Diseases: A Review

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1509 - 1538

Опубликована: Фев. 1, 2024

Abstract: Lungs experience frequent interactions with the external environment and have an abundant supply of blood; therefore, they are susceptible to invasion by pathogenic microorganisms tumor cells. However, limited pharmacokinetics conventional drugs in lungs poses a clinical challenge. The emergence different nano-formulations has been facilitated advancements nanotechnology. Inhaled nanomedicines exhibit better targeting prolonged therapeutic effects. Although great potential, still present several unknown risks. Herein, we review (1) physiological anatomy their biological barriers, (2) toxicology nanomaterial formulations lungs; (3) current nanomaterials that can be applied respiratory system related design strategies, (4) applications inhaled treating disorders, vaccine design, imaging detection based on characteristics nanomaterials. Finally, (5) analyze summarize challenges prospects for disease applications. We believe nanomaterials, particularly nano-formulations, excellent application diseases. emphasize simultaneous toxic side effects must considered during these emerging medicines. This study aims offer comprehensive guidelines valuable insights conducting research domain system. Keywords: nanoparticles, system, lungs, nanotechnology

Язык: Английский

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Principles for optimization and validation of mRNA lipid nanoparticle vaccines against COVID-19 using 3D bioprinting

Nano Today, Год журнала: 2022, Номер 43, С. 101403 - 101403

Опубликована: Янв. 20, 2022

Язык: Английский

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Diagnostic assay and technology advancement for detecting SARS-CoV-2 infections causing the COVID-19 pandemic

Analytical and Bioanalytical Chemistry, Год журнала: 2022, Номер 414(9), С. 2903 - 2934

Опубликована: Фев. 25, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused COVID-19 pandemic has transmitted to humans in practically all parts of the world, producing socio-economic turmoil. There is an urgent need for precise, fast, and affordable diagnostic testing be widely available detecting SARS-CoV-2 its mutations various phases disease. Early diagnosis with great precision been achieved using real-time polymerase chain reaction (RT-PCR) similar other molecular methods, but theseapproaches are costly involve rigorous processes that not easily obtainable. Conversely, immunoassays detect a small number antibodies have employed quick, low-cost tests, their efficiency diagnosing infected people restricted. use biosensors detection vital pandemic's control. This review gives overview approaches currently being developed as well nanomaterial-based biosensor technologies, aid future technological advancement innovation. These can integrated into point-of-care (POC) devices quickly identify large patients asymptomatic carriers. ongoing research endeavors developments complementary technologies will play significant role curbing spread fill knowledge gaps current accuracy capacity.

Язык: Английский

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The use of nanotechnology in the fight against viruses: A critical review

Coordination Chemistry Reviews, Год журнала: 2022, Номер 464, С. 214559 - 214559

Опубликована: Апрель 13, 2022

Язык: Английский

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COVID-19 inflammation and implications in drug delivery

Journal of Controlled Release, Год журнала: 2022, Номер 346, С. 260 - 274

Опубликована: Апрель 27, 2022

Язык: Английский

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Emerging importance of nanotechnology-based approaches to control the COVID-19 pandemic; focus on nanomedicine iterance in diagnosis and treatment of COVID-19 patients

Journal of Drug Delivery Science and Technology, Год журнала: 2021, Номер 67, С. 102967 - 102967

Опубликована: Ноя. 6, 2021

Язык: Английский

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