Abstract
The
strong
anti‐inflammatory
effect
of
methylprednisolone
(MP)
is
a
necessary
treatment
for
various
severe
cases
including
acute
spinal
cord
injury
(SCI).
However,
concerns
have
been
raised
regarding
adverse
effects
from
MP,
which
also
severely
limits
its
clinical
application.
Natural
polyphenols,
due
to
their
rich
phenolic
hydroxyl
chemical
properties,
can
form
dynamic
structures
without
additional
modification,
achieving
targeted
enrichment
and
drug
release
at
the
disease
lesion,
making
them
highly
promising
carrier.
Considering
application
challenges
natural
polyphenolic
platform
employed
efficient
delivery
reducing
systemic
side
effects.
Both
in
vitro
SCI
models
demonstrated
polyphenols
multiple
advantages
as
carriers
delivering
MP:
(1)
Achieved
maximum
injured
site
2
h
post‐administration,
met
desires
early
diseases;
(2)
Traceless
MP;
(3)
Reducing
effects;
(4)
Endowed
system
with
new
antioxidative
an
aspect
that
needs
be
addressed
diseases
treatment.
This
study
highlighted
prospect
robust
based
on
successfully
overcome
barrier
MP
treatment,
providing
possibility
widespread
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 18, 2024
Abstract
Acute
lung
injury
(
ALI
)
is
a
common
complication
in
patients
with
severe
burns
and
has
complex
pathogenesis
high
morbidity
mortality
rates.
A
variety
of
drugs
have
been
identified
the
clinic
for
treatment
ALI,
but
they
toxic
side
effects
caused
by
easy
degradation
body
distribution
throughout
body.
In
recent
years,
as
understanding
mechanism
underlying
improved,
scholars
developed
new
nanomaterials
that
can
be
safely
effectively
targeted
ALI.
Most
these
methods
involve
such
lipids,
organic
polymers,
peptides,
extracellular
vesicles
or
cell
membranes,
inorganic
nanoparticles
other
nanomaterials,
which
are
to
reach
tissues
perform
their
functions
through
active
targeting
passive
targeting,
process
involves
cells
organelles.
this
review,
first,
mechanisms
pathophysiological
features
occurrence
after
burn
reviewed,
potential
therapeutic
targets
summarized,
existing
classified,
possible
problems
challenges
discussed
provide
reference
development
Abstract
Immunotherapy
has
recently
emerged
as
a
promising
therapeutic
modality
for
the
treatment
of
various
diseases
such
cancer,
inflammation,
autoimmune
diseases,
and
infectious
diseases.
Despite
its
potential,
immunotherapy
faces
challenges
related
to
delivery
efficiency
off‐target
toxicity
immunotherapeutic
drugs.
Nano
drug
systems
offer
improvements
in
biodistribution
release
kinetics
but
still
suffer
from
shortcomings
high
immunogenicity,
poor
penetration
across
biological
barriers,
insufficient
tissue
permeability.
Targeted
drugs
using
living
cells
become
an
emerging
strategy
that
can
take
advantage
inherent
characteristics
deal
with
defects
nano
systems.
Furthermore,
themselves
be
genetically
engineered
into
cellular
enhanced
immunotherapy.
This
review
provides
in‐depth
exploration
cell‐derived
carriers,
detailing
their
properties,
functions,
commonly
used
loading
strategies.
In
addition,
role
modified
synergistic
effects
are
also
introduced.
By
summarizing
main
advancements
limitations
field,
this
offers
insights
potential
cell‐based
address
existing
The
introduction
recent
developments
evaluation
ongoing
research
will
pave
way
optimization
widespread
adoption
nano/genetically
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Фев. 21, 2023
Cell
therapies
are
emerging
as
a
promising
new
therapeutic
modality
in
medicine,
generating
effective
treatments
for
previously
incurable
diseases.
Clinical
success
of
cell
has
energized
the
field
cellular
engineering,
spurring
further
exploration
novel
approaches
to
improve
their
performance.
Engineering
surfaces
using
natural
and
synthetic
materials
emerged
valuable
tool
this
endeavor.
This
review
summarizes
recent
advances
development
technologies
decorating
with
various
including
nanoparticles,
microparticles,
polymeric
coatings,
focusing
on
ways
which
surface
decorations
enhance
carrier
cells
effects.
Key
benefits
surface-modified
include
protecting
cell,
reducing
particle
clearance,
enhancing
trafficking,
masking
cell-surface
antigens,
modulating
inflammatory
phenotype
cells,
delivering
agents
target
tissues.
While
most
these
still
proof-of-concept
stage,
efficacy
constructs
from
vitro
vivo
preclinical
studies
laid
strong
foundation
eventual
clinical
translation.
engineering
can
imbue
diverse
range
advantages
therapy,
creating
opportunities
innovative
functionalities,
improved
efficacy,
transforming
fundamental
translational
landscape
therapies.
Regenerative Biomaterials,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 1, 2023
Liposome,
a
widely
used
drug
delivery
system
(DDS),
still
shows
several
disadvantages
such
as
dominant
clearance
by
liver
and
poor
target
organ
deposition.
To
overcome
the
drawbacks
of
liposomes,
we
developed
novel
red
blood
cell
(RBC)-liposome
combined
DDS
to
modulate
tumor
accumulation
extend
circulation
life
existing
liposomal
DDS.
Here,
RBCs,
an
ideal
natural
carrier
DDS,
were
utilized
carry
liposomes
avoid
them
undergo
fast
in
blood.
In
this
study,
could
either
absorbed
onto
RBCs'
surface
or
fuse
with
membrane
merely
altering
interaction
time
at
37°C,
while
between
liposome
RBCs
would
not
affect
characteristics.
vivo
antitumor
therapeutic
efficacy
1,2-dipalmitoyl-sn-glycero-3-phosphocholine
(DPPC)
attached
surfaces
exhibited
lung
targeting
effect
(via
RBC-hitchhiking
approach)
reduced
liver,
DPPC
fused
had
prolong
up
48
h
no
enrichment
any
organ.
Furthermore,
20
mol%
replaced
pH-sensitive
phospholipid
1,2-dioleoyl-Sn-glycero-3-phosphoethanolamine
(DOPE)
it
respond
low
pH
microenvironment
then
accumulate
tumor.
The
DOPE
attached/fusion
showed
partial
about
5-8%
accumulation,
which
significantly
higher
than
(about
0.7%)
conventional
Thus,
RBC-liposome
composite
is
able
improve
clinical
application
promises
using
autologous
for
therapy.
Theranostics,
Год журнала:
2023,
Номер
14(1), С. 220 - 248
Опубликована: Ноя. 15, 2023
Red
blood
cells
(RBCs)
are
the
most
abundant
cell
type
in
blood,
and
play
a
critical
role
oxygen
transport.With
development
of
nanobiotechnology
synthetic
biology,
scientists
have
found
multiple
ways
to
take
advantage
characteristics
RBCs,
such
as
their
long
circulation
time,
construct
universal
develop
drug
delivery
systems,
transform
therapies
for
cancer
other
diseases.This
article
reviews
component
aging
mystery
methods
applied
application
prospects
engineering
modification
RBCs
used
cytopharmaceuticals
immunotherapy.Finally,
we
summarize
some
perspectives
on
biological
features
provide
further
insights
into
translational
medicine.
