Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122935 - 122935
Published: Nov. 4, 2024
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 18, 2024
Abstract Acute lung injury ( ALI ) is a common complication in patients with severe burns and has complex pathogenesis high morbidity mortality rates. A variety of drugs have been identified the clinic for treatment ALI, but they toxic side effects caused by easy degradation body distribution throughout body. In recent years, as understanding mechanism underlying improved, scholars developed new nanomaterials that can be safely effectively targeted ALI. Most these methods involve such lipids, organic polymers, peptides, extracellular vesicles or cell membranes, inorganic nanoparticles other nanomaterials, which are to reach tissues perform their functions through active targeting passive targeting, process involves cells organelles. this review, first, mechanisms pathophysiological features occurrence after burn reviewed, potential therapeutic targets summarized, existing classified, possible problems challenges discussed provide reference development
Language: Английский
Citations
11
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(11), P. 944 - 959
Published: July 15, 2024
Language: Английский
Citations
11
BMEMat, Journal Year: 2024, Volume and Issue: unknown
Published: July 17, 2024
Abstract Immunotherapy has recently emerged as a promising therapeutic modality for the treatment of various diseases such cancer, inflammation, autoimmune diseases, and infectious diseases. Despite its potential, immunotherapy faces challenges related to delivery efficiency off‐target toxicity immunotherapeutic drugs. Nano drug systems offer improvements in biodistribution release kinetics but still suffer from shortcomings high immunogenicity, poor penetration across biological barriers, insufficient tissue permeability. Targeted drugs using living cells become an emerging strategy that can take advantage inherent characteristics deal with defects nano systems. Furthermore, themselves be genetically engineered into cellular enhanced immunotherapy. This review provides in‐depth exploration cell‐derived carriers, detailing their properties, functions, commonly used loading strategies. In addition, role modified synergistic effects are also introduced. By summarizing main advancements limitations field, this offers insights potential cell‐based address existing The introduction recent developments evaluation ongoing research will pave way optimization widespread adoption nano/genetically
Language: Английский
Citations
9
Pharmaceutical Research, Journal Year: 2022, Volume and Issue: 39(11), P. 2673 - 2698
Published: July 7, 2022
Language: Английский
Citations
30
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Aug. 22, 2023
Abstract Red blood cells (RBCs) are the most abundant in body, possessing unique biological and physical properties. RBCs have demonstrated outstanding potential as delivery vehicles due to their low immunogenicity, long-circulating cycle, immune characteristics, exhibiting abilities. There been several developments understanding system of derivatives, they applied various aspects biomedicine. This article compared physiological characteristics RBCs, analyzed advantages systems, summarized existing practices Graphical
Language: Английский
Citations
22
Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 10
Published: Jan. 1, 2023
Liposome, a widely used drug delivery system (DDS), still shows several disadvantages such as dominant clearance by liver and poor target organ deposition. To overcome the drawbacks of liposomes, we developed novel red blood cell (RBC)-liposome combined DDS to modulate tumor accumulation extend circulation life existing liposomal DDS. Here, RBCs, an ideal natural carrier DDS, were utilized carry liposomes avoid them undergo fast in blood. In this study, could either absorbed onto RBCs' surface or fuse with membrane merely altering interaction time at 37°C, while between liposome RBCs would not affect characteristics. vivo antitumor therapeutic efficacy 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) attached surfaces exhibited lung targeting effect (via RBC-hitchhiking approach) reduced liver, DPPC fused had prolong up 48 h no enrichment any organ. Furthermore, 20 mol% replaced pH-sensitive phospholipid 1,2-dioleoyl-Sn-glycero-3-phosphoethanolamine (DOPE) it respond low pH microenvironment then accumulate tumor. The DOPE attached/fusion showed partial about 5-8% accumulation, which significantly higher than (about 0.7%) conventional Thus, RBC-liposome composite is able improve clinical application promises using autologous for therapy.
Language: Английский
Citations
21
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: Feb. 21, 2023
Cell therapies are emerging as a promising new therapeutic modality in medicine, generating effective treatments for previously incurable diseases. Clinical success of cell has energized the field cellular engineering, spurring further exploration novel approaches to improve their performance. Engineering surfaces using natural and synthetic materials emerged valuable tool this endeavor. This review summarizes recent advances development technologies decorating with various including nanoparticles, microparticles, polymeric coatings, focusing on ways which surface decorations enhance carrier cells effects. Key benefits surface-modified include protecting cell, reducing particle clearance, enhancing trafficking, masking cell-surface antigens, modulating inflammatory phenotype cells, delivering agents target tissues. While most these still proof-of-concept stage, efficacy constructs from vitro vivo preclinical studies laid strong foundation eventual clinical translation. engineering can imbue diverse range advantages therapy, creating opportunities innovative functionalities, improved efficacy, transforming fundamental translational landscape therapies.
Language: Английский
Citations
20
International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 619, P. 121719 - 121719
Published: April 4, 2022
Language: Английский
Citations
26
Inflammation, Journal Year: 2022, Volume and Issue: 45(6), P. 2124 - 2141
Published: May 31, 2022
Language: Английский
Citations
23
Small, Journal Year: 2024, Volume and Issue: 20(25)
Published: Jan. 9, 2024
Abstract Living cell‐mediated nanodelivery system is considered a promising candidate for targeted antitumor therapy; however, their use restricted by the adverse interactions between carrier cells and nanocargos. Herein, novel erythrocyte‐based developed assembling renal‐clearable copper sulfide (CuS) nanodots on outer membranes of erythrocytes via lipid fusion approach, demonstrate that it an efficient photothermal platform against hepatocellular carcinoma. After intravenous injection system, CuS assembled can be released from accumulate in tumors response to high shear stress bloodstream, show excellent effect under near infrared laser irradiation. Therefore, erythrocyte‐mediated holds many advantages including prolonged blood circulation duration enhanced tumor accumulation. Significantly, elimination half‐life 74.75 ± 8.77 h, which much longer than (33.56 2.36 h). Moreover, other two kinds well onto produce hitchhiking platforms. Together, findings promote not only development systems as potential platforms treatment but also further clinical translation toward personalized healthcare.
Language: Английский
Citations
5