Mesoporous silica nanoparticles with chiral pattern topological structure function as “antiskid tires” on the intestinal mucosa to facilitate oral drugs delivery DOI Creative Commons
Xin Wei, Lin Wang,

Jiahui Lin

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 18(2), С. 100795 - 100795

Опубликована: Фев. 25, 2023

The weak adhesion between nanocarriers and the intestinal mucosa was one of main reasons caused failure in oral delivery. Inspired by "antiskid tires" with complex chiral patterns, mesoporous silica nanoparticles AT-R@CMSN exhibiting geometrical structure were designed to improve surface/interface roughness nanoscale, employed as hosting system for insoluble drugs nimesulide (NMS) ibuprofen (IBU). Once performing delivery tasks, rigid skeleton protected loaded drug reduced irritation on gastrointestinal tract (GIT), while their porous deprived crystal improved release. More importantly, functioned tire" produce higher friction substantively influenced multiple biological processes, including "contact", "adhesion", "retention", "permeation" "uptake", compared achiral S@MSN, thereby improving adsorption effectiveness such systems. By engineering overcome stability, solubility permeability bottlenecks drugs, orally administered NMS or IBU could achieve relative bioavailability (705.95% 444.42%, respectively) stronger anti-inflammation effect. In addition, displayed favorable biocompatibility biodegradability. Undoubtedly, present finding helped understand process nanocarriers, provided novel insights into rational design nanocarriers.

Язык: Английский

Nanomaterials in tumor immunotherapy: new strategies and challenges DOI Creative Commons
Xudong Zhu, Shenglong Li

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Июнь 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Язык: Английский

Процитировано

119
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

и другие.

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

Процитировано

7
Advanced drug delivery platforms target cancer stem cells DOI Creative Commons

MirAhmad Mazloomi,

Abolfazl Doustmihan, Sajjad Alimohammadvand

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101036 - 101036

Опубликована: Фев. 1, 2025

Процитировано

3
Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy DOI Creative Commons
Yuemin Wang, Duan Wang, Yuyue Zhang

и другие.

Bioactive Materials, Год журнала: 2022, Номер 22, С. 239 - 253

Опубликована: Окт. 7, 2022

Chemodynamic therapy (CDT), a noninvasive strategy, has emerged as promising alternative to conventional chemotherapy for treating tumors. However, its therapeutic effect is limited by the amount of H2O2, pH value, hypoxic environment tumors, and it suboptimal tumor-targeting ability. In this study, tumor cell membrane-camouflaged mesoporous Fe3O4 nanoparticles loaded with perfluoropentane (PFP) glucose oxidase (GOx) are used microenvironment-adaptive nanoplatform ([email protected]2-G), which synergistically enhances antitumor CDT. Mesoporous selected inducers photothermal Fenton reactions nanocarriers. GOx depletes within cells starving cells, while producing H2O2 subsequent ·OH generation. Moreover, PFP, can carry O2, relieves hypoxia in provides O2 cascade reaction. Finally, camouflaged osteosarcoma membranes, endowing homologous targeting immune escape abilities. Both vivo vitro evaluations reveal high synergistic efficacy [email protected]2-G, desirable tumor-inhibition rate (90.50%), indicates great potential platform clinical cancer.

Язык: Английский

Процитировано

56
Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: novel insights and perspectives DOI Creative Commons
Haiying Wang, Qiao Chu,

Qiutong Guan

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 18(4), С. 100829 - 100829

Опубликована: Июль 1, 2023

Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.

Язык: Английский

Процитировано

38
MOFs‐Based Magnetic Nanozyme to Boost Cascade ROS Accumulation for Augmented Tumor Ferroptosis DOI
Ying Yuan, Bo Chen,

Xingxing An

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(20)

Опубликована: Март 26, 2024

The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. A metal-organic frameworks (MOFs)-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid, delivering excellent magnetophotonic response efficient ferroptosis, is reported here. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase-like catalysis to generate O

Язык: Английский

Процитировано

14
Nanozyme-enhanced ferroptosis for cancer treatment DOI Creative Commons
Yue Ming, Mingshu Huang, Yisheng Huang

и другие.

Materials Chemistry Frontiers, Год журнала: 2024, Номер 8(7), С. 1685 - 1702

Опубликована: Янв. 1, 2024

Nanozymes could mimic the catalytic activity of natural enzymes, then stimulate Fenton reaction for reactive oxygen species overproduction and lipid peroxidation, ultimately induce ferroptosis to exert anticancer effects.

Язык: Английский

Процитировано

13
Ferroptosis inducers: A new frontier in cancer therapy DOI
Wenjing Ma,

Naiyuan Hu,

Wenqian Xu

и другие.

Bioorganic Chemistry, Год журнала: 2024, Номер 146, С. 107331 - 107331

Опубликована: Апрель 2, 2024

Язык: Английский

Процитировано

10
Intelligent Size‐Switchable Iron Carbide‐Based Nanocapsules with Cascade Delivery Capacity for Hyperthermia‐Enhanced Deep Tumor Ferroptosis DOI
Jingjing Wang, Zhi Fang, Chenyang Zhao

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(9)

Опубликована: Ноя. 4, 2023

The ferroptosis pathway is recognized as an essential strategy for tumor treatment. However, killing cells in deep regions with agents still challenging because of distinct size requirements intratumoral accumulation and penetration. Herein, intelligent nanocapsules size-switchable capability that responds to acid/hyperthermia stimulation achieve are developed. These constructed using poly(lactic-co-glycolic) acid Pluronic F127 carrier materials, Au-Fe

Язык: Английский

Процитировано

21
Activatable Semiconducting Polymer Nanoinducers Amplify Oxidative Damage via Sono-Ferroptosis for Synergistic Therapy of Bone Metastasis DOI
Yijing Zhang, Qin Zhang,

Fengshuo Wang

и другие.

Nano Letters, Год журнала: 2023, Номер 23(16), С. 7699 - 7708

Опубликована: Авг. 11, 2023

Bone metastases are secondary malignant tumors that commonly occur after the spread of advanced cancer cells. We herein report activatable semiconducting polymer nanoinducers (ASPNFP) can amplify oxidative damage via sono-ferroptosis for bone metastasis treatment. ASPNFP constructed by encapsulating plasma amine oxidase-based nanoparticles (SPNP) and Fe3O4 into singlet oxygen (1O2)-responsive nanocarriers. generate 1O2 under ultrasound (US) irradiation a sonodynamic effect to destroy stability 1O2-responsive nanocarriers, allowing US-triggered releases SPNP nanoparticles. decompose polyamines in tumor cells produce acrolein hydrogen peroxide (H2O2), which H2O2 promotes Fenton reaction mediated inducing enhanced ferroptosis generation hydroxyl radicals (•OH). The generated acrolein, 1O2, •OH simultaneously damage. thus mediate an amplified inhibit growth restrict metastasis.

Язык: Английский

Процитировано

18