International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
661, С. 124420 - 124420
Опубликована: Июль 5, 2024
Colorectal
cancer
represents
a
worldwide
spread
type
of
and
it
is
regarded
as
one
the
leading
death
causes,
along
with
lung,
breast,
prostate
cancers.
Since
conventional
surgical
resection
chemotherapy
proved
limited
efficiency,
use
alternative
drug
delivery
systems
that
ensure
controlled
release
cytostatic
agents
possess
immense
potential
for
treatment.
In
this
regard,
present
study
aimed
to
develop
evaluate
efficiency
series
irinotecan-loaded
magnetite-silica
core-shell
systems.
The
magnetite
particles
were
obtained
through
solvothermal
treatment,
while
silica
shell
was
Stöber
method
directly
onto
surface
particles.
Subsequently,
physico-chemically
morpho-structurally
evaluated
trough
X-ray
diffraction
(XRD)
(high-resolution)
transmission
electron
microscopy
((HR-)TEM)
equipped
High
Annular
Angular
Dark
Field
Detector
(HAADF)
elemental
mapping.
After
irinotecan
loading,
Fourier-transform
infrared
spectroscopy
(FT-IR),
thermogravimetry
differential
scanning
calorimetry
(TG-DSC),
UV-Vis
spectrophotometry.
Additionally,
Brunauer-Emmett-Teller
(BET)
employed
determining
area
pore
volume
biological
functionality
core-shells
investigated
MTT
assay
performed
on
both
normal
cells.
results
confirmed
formation
highly
crystalline
comprising
core
mesoporous
layers
sizes
varying
between
2
7
nm
shell.
loading
dependent
synthesis
procedure,
since
lack
hexadecyltrimethylammonium
bromide
(CTAB)
resulted
in
higher
but
lower
cumulative
release.
Moreover,
nanostructured
demonstrated
targeted
towards
HT-29
colorectal
adenocarcinoma
cells,
case
L929
fibroblast
cell
viability
than
pristine
drug.
manner,
provides
means
procedures
developing
applicability
treatment
cancer.
Biomolecules,
Год журнала:
2022,
Номер
12(6), С. 784 - 784
Опубликована: Июнь 4, 2022
Cancer
is
one
of
the
main
causes
death
worldwide.
To
date,
and
despite
advances
in
conventional
treatment
options,
therapy
cancer
still
far
from
optimal
due
to
non-specific
systemic
biodistribution
antitumor
agents.
The
inadequate
drug
concentrations
at
tumor
site
led
an
increased
incidence
multiple
resistance
appearance
many
severe
undesirable
side
effects.
Nanotechnology,
through
development
nanoscale-based
pharmaceuticals,
has
emerged
provide
new
innovative
drugs
overcome
these
limitations.
In
this
review,
we
overview
approved
nanomedicine
for
rationale
behind
their
designs
applications.
We
also
highlight
approaches
that
are
currently
under
investigation
perspectives
challenges
nanopharmaceuticals,
focusing
on
microenvironment
disseminate
cells
as
most
attractive
effective
strategies
treatments.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 16, 2023
When
hydrogel
materials
with
excellent
biocompatibility
and
biodegradability
are
used
as
new
drug
carriers
in
the
treatment
of
cancer,
they
confer
following
three
advantages.
First,
can
be
a
precise
controlled
release
systems,
which
continuously
sequentially
chemotherapeutic
drugs,
radionuclides,
immunosuppressants,
hyperthermia
agents,
phototherapy
agents
other
substances
widely
cancer
through
radiotherapy,
chemotherapy,
immunotherapy,
hyperthermia,
photodynamic
therapy
photothermal
therapy.
Second,
have
multiple
sizes
delivery
routes,
targeted
to
different
locations
types
cancer.
This
greatly
improves
targeting
thereby
reducing
dose
drugs
improving
effectiveness.
Finally,
intelligently
respond
environmental
changes
according
internal
external
stimuli
so
that
anti-cancer
active
remotely
released
on
demand.
Combining
abovementioned
advantages,
transformed
into
hit
field
treatment,
bringing
hope
further
increase
survival
rate
quality
life
patients
Cancers,
Год журнала:
2024,
Номер
16(6), С. 1156 - 1156
Опубликована: Март 14, 2024
Hyperthermia
(HT)
is
an
anti-cancer
therapy
commonly
used
with
radio
and
chemotherapies
based
on
applying
heat
(39-45
°C)
to
inhibit
tumor
growth.
However,
controlling
towards
tumors
not
normal
tissues
challenging.
Therefore,
nanoparticles
(NPs)
are
in
HT
apply
only
induce
DNA
damage
the
expression
of
shock
proteins,
which
eventually
result
apoptosis.
The
aim
this
review
article
summarize
recent
advancements
use
magnetic
NPs
locally
increase
temperature
promote
cell
death.
In
addition,
development
nanocarriers
as
NP-based
drug
delivery
systems
discussed.
Finally,
efficacy
combined
chemotherapy,
radiotherapy,
gene
therapy,
photothermal
immunotherapy
explored.
Since
their
inception
in
the
early
1960s,
development
and
use
of
nanoscale
materials
have
progressed
tremendously,
roles
diverse
fields
ranging
from
human
health
to
energy
electronics
are
undeniable.
The
application
nanotechnology
inventions
has
revolutionized
many
aspects
everyday
life
including
various
medical
applications
specifically
drug
delivery
systems,
maximizing
therapeutic
efficacy
contained
drugs
by
means
bioavailability
enhancement
or
minimization
adverse
effects.
In
this
review,
we
utilize
CAS
Content
Collection,
a
vast
repository
scientific
information
extracted
journal
patent
publications,
analyze
trends
nanoscience
research
relevant
an
effort
provide
comprehensive
detailed
picture
field.
We
examine
publication
landscape
area
insights
into
current
knowledge
advances
developments.
review
major
classes
nanosized
routes,
targeted
diseases.
outline
most
discussed
concepts
assess
advantages
nanocarriers.
objective
is
broad
overview
evolving
regarding
challenges,
evaluate
growth
opportunities.
merit
stems
extensive,
wide-ranging
coverage
up-to-date
information,
allowing
unmatched
breadth
analysis
in-depth
insights.
Light Science & Applications,
Год журнала:
2024,
Номер
13(1)
Опубликована: Сен. 3, 2024
Abstract
Chemotherapy
is
one
of
the
conventional
treatments
for
cancer
in
clinical
practice.
However,
poor
delivery
efficiency,
systemic
toxicity,
and
lack
pharmacokinetic
monitoring
during
treatment
are
critical
limitations
current
chemotherapy.
Herein,
we
reported
a
brand-new
antitumor
drug
strategy
that
harnesses
an
optical
fiber
endoscopically
therapeutic
probe.
The
probe
carries
photosensitizers
core
agents
on
surface
mediated
by
temperature-responsive
hydrogel
film,
giving
rise
to
activable
photothermal-chemotherapy
orchestrates
localized
hyperthermia
thermal-stimuli
release
tumor
lesion.
Furthermore,
dynamical
in-situ
temperature
can
be
real-time
supervised
through
built-in
sensors,
including
reflective
Mach–Zehnder
interferometer
Bragg
grating,
visualize
therapy
process
thus
improve
safety
treatment.
Compared
with
methods,
fiber-optic
adequately
take
advantage
chemotherapeutics
collaboratively
recruiting
photoheating-mediated
enhanced
permeability
particle-assisted
high
retention,
shedding
new
light
“central-to-peripheral”
pervasion
retention
mechanism
destroy
tumors
completely.
chemotherapy
incorporates
precise
delivery,
accurate
controllability
release,
tumor,
low
off-target
rate,
feedback,
performing
straightforward
pathway.
More
than
that,
proposed
holds
tremendous
promise
provide
revolutionized
on-demand
platform
highly
efficient
evaluation
screening
pharmaceuticals.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(3), С. 315 - 315
Опубликована: Фев. 28, 2024
Cancer
continues
to
pose
one
of
the
most
critical
challenges
in
global
healthcare.
Despite
wide
array
existing
cancer
drugs,
primary
obstacle
remains
selectively
targeting
and
eliminating
cells
while
minimizing
damage
healthy
ones,
thereby
reducing
treatment
side
effects.
The
revolutionary
approach
utilizing
nanomaterials
for
delivering
therapeutic
agents
has
significantly
enhanced
efficacy
safety
chemotherapeutic
drugs.
This
crucial
shift
is
attributed
unique
properties
nanomaterials,
enabling
nanocarriers
transport
tumor
sites
both
passive
active
modes,
drug
elimination
from
delivery
systems.
Furthermore,
these
can
be
designed
respond
internal
or
external
stimuli,
thus
facilitating
controlled
release.
However,
production
nanomedications
therapy
encounters
various
that
impede
progress
this
field.
review
aims
provide
a
comprehensive
overview
current
state
nanomedication
treatment.
It
explores
variety
focusing
on
their
are
overcoming
limitations
conventional
chemotherapy.
Additionally,
delves
into
functionalities
nanocarriers,
highlighting
significant
impact
evolution
nanomedicine.
also
critically
assesses
recent
advancements
systems,
covering
range
innovative
methodologies.
Finally,
succinctly
addresses
encountered
developing
nanomedications,
offering
insightful
perspectives
guide
future
research
