Synergistic effects of multidrug/material combination deliver system for anti-mutidrug-resistant tumor DOI
Fangyuan Guo, Yunlong Jiao,

Wenqin Ding

и другие.

International Journal of Pharmaceutics, Год журнала: 2023, Номер 649, С. 123669 - 123669

Опубликована: Дек. 4, 2023

Язык: Английский

Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications DOI

Fatemeh Askarizadeh,

Alexandra E. Butler, Prashant Kesharwani

и другие.

Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115369 - 115369

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Recent advances in PD-L1 siRNA nanocarriers for cancer therapy DOI

Sristi,

Garima Gupta, Mohammed A. S. Abourehab

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143994 - 143994

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Tazarotene-calcipotriol loaded Nanostructured lipid carrier enriched hydrogel: A novel dual drug synergistic approach towards Psoriasis management DOI
S.S. Thakur, Md Meraj Anjum, Shweta Jaiswal

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 88, С. 104944 - 104944

Опубликована: Сен. 15, 2023

Язык: Английский

Процитировано

8
Neutralizing tumor-related inflammation and reprogramming of cancer-associated fibroblasts by Curcumin in breast cancer therapy DOI Creative Commons

Elnaz Jalilian,

Firoozeh Abolhasani Zadeh, Ali Afgar

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Ноя. 26, 2023

Abstract Tumor-associated inflammation plays a vital role in cancer progression. Among the various stromal cells, cancer-associated fibroblasts are promising targets for therapy. Several reports have indicated potent anti-inflammatory effects attributed to Curcumin. This study aimed investigate whether inhibiting inflammatory function of (CAFs) with Curcumin can restore anticancer immune responses. CAFs were isolated from breast tissues, treated Curcumin, and co-cultured patients' PBMCs evaluate gene expression cytokine production alterations. Blood tumor tissue samples obtained 12 patients stage II/III invasive ductal carcinoma. Fibroblast Activation Protein (FAP) + extracted tissue, 10 μM corresponding PBMCs. The smooth muscle actin-alpha (α-SMA), Cyclooxygenase-2(COX-2), PGE2, cell cytokines evaluated using Real-Time PCR ELISA, respectively. Analyzes showed that treatment decreased genes α-SMA COX-2 PGE2 CAFs. In Curcumin-treated CAFs, FoxP3 along TGF-β, IL-10, IL-4. An increase IFN-γ was observed followed by increased T-bet expression. According our results, could reprogram pro-tumor phenotype anti-tumor Thus, as component microenvironment, suitable target combination immunotherapies cancer.

Язык: Английский

Процитировано

8
Synergistic effects of multidrug/material combination deliver system for anti-mutidrug-resistant tumor DOI
Fangyuan Guo, Yunlong Jiao,

Wenqin Ding

и другие.

International Journal of Pharmaceutics, Год журнала: 2023, Номер 649, С. 123669 - 123669

Опубликована: Дек. 4, 2023

Язык: Английский

Процитировано

6