Psoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis DOI Creative Commons
Nan Jin, Leaf Huang, Xin Chen

и другие.

European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 205, С. 107000 - 107000

Опубликована: Дек. 25, 2024

Blue light will be a promising alternative for photodynamic therapy in psoriasis, but the photosensitizer vivo remains unexplored. Mesoporous zinc phosphate microparticle (MZP) was synthesized successfully this study, as evidenced by XPS, XRD, and nitrogen adsorption experiments. Its psoriatic skin-sensitive property corroborated SEM higher cumulative release rate of that impregnated with curcumin (Cur) glycyrrhizic acid (GA), namely Cur-GA-MZP, at pH 5.4, which mimic acidic environment inflammatory skin. Moreover, detecting decrease absorbance 1,3-Diphenylisobenzofuran (DPBF) had been mixed MZP irradiated blue light, is confirmed to reinforce ROS along irradiation time rather than 7.2. This phenomenon led strengthened anti-inflammatory effect on xylene-induced auricle inflammation, well imiquimod-induced psoriatic-like plaques exists only under irradiation, alleviated macroscopic microscopic appearance, decreased IL-17A levels skin lesion area spleen index. The mechanism likely attributed NFƙB pathway MAPK detected western blot. In sum, MZP, could dissociate condition, prerequisite an effective management psoriasis.

Язык: Английский

Resveratrol-Ampicillin Dual-Drug Loaded Polyvinylpyrrolidone/Polyvinyl Alcohol Biomimic Electrospun Nanofiber Enriched with Collagen for Efficient Burn Wound Repair DOI Creative Commons
Shubham Kanaujiya, Dilip Kumar Arya, Prashant Pandey

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5397 - 5418

Опубликована: Июнь 1, 2024

Background: The healing of burn wounds is a complicated physiological process that involves several stages, including haemostasis, inflammation, proliferation, and remodelling to rebuild the skin subcutaneous tissue integrity. Recent advancements in nanomaterials, especially nanofibers, have opened new way for efficient due burning or other injuries. Methods: This study aims develop characterize collagen-decorated, bilayered electrospun nanofibrous mats composed PVP PVA loaded with Resveratrol (RSV) Ampicillin (AMP) accelerate wound repair. Results: Nanofibers smooth surfaces web-like structures diameters ranging from 200 400 nm were successfully produced by electrospinning. These fibres exhibited excellent vitro properties, ability absorb exudates undergo biodegradation over two-week period. Additionally, these nanofibers demonstrated sustained controlled release encapsulated through studies. zone inhibition (ZOI) PVP-PVA-RSV-AMP against Staphylococcus aureus ( S. aureus) Escherichia coli E. ) was found 31± 0.09 mm 12± 0.03, respectively, which significantly higher as compared positive control. Similarly, biofilm confirmed significant reduction formation biofilms nanofiber-treated group both . X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FTIR) analysis proved encapsulation RSV AMP into their compatibility. Haemolysis assay (%) showed no haemolysis (less than 5%) groups, cytocompatibility red blood cells (RBCs). Cell viability cell adhesion on HaCaT increased indicating its biocompatibility well non-toxic properties. Results in-vivo experiments model potential rats H&E-stained images also improved collagen synthesis nanofibers-treated groups evidenced Masson-trichrome staining. ELISA clearly indicated downregulation TNF-alpha IL-6 inflammatory biomarkers after treatment day 10. Conclusion: AMP-loaded nanofiber mats, developed this study, expedite multifaceted approach. Keywords: electrospinning, nanofiber, resveratrol, ampicillin, healing,

Язык: Английский

Процитировано

14

Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles DOI Creative Commons

Krisztina Bodnár,

Pálma Fehér,

Zoltán Ujhelyi

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(4), С. 449 - 449

Опубликована: Март 25, 2024

Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of cells, which leads to formation thick, red, scaly patches on surface skin. These can be itchy painful, they may cause discomfort for patients affected this condition. Therapies psoriasis aim alleviate symptoms, reduce inflammation, slow down cell growth. Conventional topical treatment options are non-specific, have low efficacy associated with adverse effects, why researchers investigating different delivery mechanisms. A novel approach drug using nanoparticles (NPs) shows promise in reducing toxicity improving therapeutic efficacy. The unique properties NPs, such as their small size large area, make them attractive targeted delivery, enhanced stability, controlled release. In context PSO, NPs designed deliver active ingredients anti-inflammatory effect, immunosuppressants, or other compounds directly areas. formulations offer improved access epidermis facilitate better absorption, thus enhancing conventional anti-psoriatic drugs. increase surface-to-volume ratio, resulting penetration through skin, including intracellular, intercellular, trans-appendage routes. present review aims discuss latest approaches therapy PSO NPs. It intended summarize results vitro vivo examinations carried out last few years regarding effectiveness safety nanoparticles.

Язык: Английский

Процитировано

13

Topical Therapy in Psoriasis: Clinical Benefits, Advances in Novel Drug Delivery Strategies, and Gene Therapy Regimen DOI Creative Commons
Ying Zhu, Yong Zhou, Xiao-Nan Ma

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 283 - 283

Опубликована: Фев. 20, 2025

Psoriasis is a chronic inflammatory disease with complex pathogenesis, influenced by various factors involving environment, genes, and immunity. The main symptoms of psoriasis include erythema, scales, itching, etc. At present, therapeutic drugs for are continually evolving towards enhancing treatment efficacy reducing side effects. Firstly, the pathogenesis characteristics were summarized. Then, types benefits topical therapy introduced, such as aspects avoiding systemic toxic effects, first pass effect, gastrointestinal reactions accelerating onset time improving its efficacy, compared to drugs. In case methotrexate, cyclosporin A, Janus kinase (JAK) inhibitors, phosphodiesterase-4 (PDE-4) this review had further discussion on improvement translation these molecules from in clinical practice. To augment limitation skin permeability, nanotechnology novel drug delivery system including nanomedicines, hydrogels, ionic liquids, microneedles elaborated management. Also, exploration targeting pathogenic genes through small interfering RNA (siRNA) using nanoparticles liquids (ILs) great significance long-term psoriasis. Taken together, development numerous platforms expected achieve enhanced penetration, precise efficient molecule interference (RNAi) therapeutics prospects.

Язык: Английский

Процитировано

1

A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning DOI

M Taha Tarek,

Riham I. El-Gogary, Amany O. Kamel

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125385 - 125385

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Surface entrenched β-sitosterol niosomes for enhanced cardioprotective activity against isoproterenol induced cardiotoxicity in rats DOI
Shweta Jaiswal, Md Meraj Anjum, Dilip Kumar Arya

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 653, С. 123872 - 123872

Опубликована: Фев. 8, 2024

Язык: Английский

Процитировано

6

Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model DOI
Beibei Lü,

Yixiu Zhong,

Jianglin Zhang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(14), С. 17080 - 17091

Опубликована: Апрель 1, 2024

Psoriasis is a systemic, recurrent, chronic autoimmune skin disease. However, psoriasis drugs have poor permeability and high toxicity, resulting in low bioavailability affecting their clinical application. In this study, we propose curcumin-based ionic liquid hydrogel loaded with ilomastat (Cur-Car-IL@Ilo hydrogel), which can effectively maintain the sustained release of improve drugs. We used model imiquimod-induced demonstrated that local application Cur-Car-IL@Ilo lesions mice significantly reduced expression levels inflammatory factors, matrix metalloproteinase 8, collagen-I. The expressions iron death-related proteins SLC7A11 ASL4 were decreased after treatment hydrogel. Flora analysis showed content anaerotruncus, proteus, UCG-009 bacteria gut psoriatic increased. paludicola, parabacteroides, prevotellaceae_UCG-001, escherichia-shigella, aerococcus decreased, some above tended to be normal treatment. Therefore, as multifunctional, nonirritating, noninvasive, highly effective percutaneous psoriasis.

Язык: Английский

Процитировано

6

Synthesis and evaluation of valsartan co-crystals for enhanced solubility and anti-hypertensive activity DOI
Rinki Verma, Md Meraj Anjum,

Devdutt Sharma

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125743 - 125743

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Evaluation of cardioprotective effect of naringin loaded lignin nanoparticles against isoproterenol induced myocardial infarction DOI
Shweta Jaiswal, Md Meraj Anjum, S.S. Thakur

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105076 - 105076

Опубликована: Окт. 18, 2023

Язык: Английский

Процитировано

7

Psoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis DOI Creative Commons
Nan Jin, Leaf Huang, Xin Chen

и другие.

European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 205, С. 107000 - 107000

Опубликована: Дек. 25, 2024

Blue light will be a promising alternative for photodynamic therapy in psoriasis, but the photosensitizer vivo remains unexplored. Mesoporous zinc phosphate microparticle (MZP) was synthesized successfully this study, as evidenced by XPS, XRD, and nitrogen adsorption experiments. Its psoriatic skin-sensitive property corroborated SEM higher cumulative release rate of that impregnated with curcumin (Cur) glycyrrhizic acid (GA), namely Cur-GA-MZP, at pH 5.4, which mimic acidic environment inflammatory skin. Moreover, detecting decrease absorbance 1,3-Diphenylisobenzofuran (DPBF) had been mixed MZP irradiated blue light, is confirmed to reinforce ROS along irradiation time rather than 7.2. This phenomenon led strengthened anti-inflammatory effect on xylene-induced auricle inflammation, well imiquimod-induced psoriatic-like plaques exists only under irradiation, alleviated macroscopic microscopic appearance, decreased IL-17A levels skin lesion area spleen index. The mechanism likely attributed NFƙB pathway MAPK detected western blot. In sum, MZP, could dissociate condition, prerequisite an effective management psoriasis.

Язык: Английский

Процитировано

0