Resveratrol-Ampicillin Dual-Drug Loaded Polyvinylpyrrolidone/Polyvinyl Alcohol Biomimic Electrospun Nanofiber Enriched with Collagen for Efficient Burn Wound Repair
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5397 - 5418
Опубликована: Июнь 1, 2024
Background:
The
healing
of
burn
wounds
is
a
complicated
physiological
process
that
involves
several
stages,
including
haemostasis,
inflammation,
proliferation,
and
remodelling
to
rebuild
the
skin
subcutaneous
tissue
integrity.
Recent
advancements
in
nanomaterials,
especially
nanofibers,
have
opened
new
way
for
efficient
due
burning
or
other
injuries.
Methods:
This
study
aims
develop
characterize
collagen-decorated,
bilayered
electrospun
nanofibrous
mats
composed
PVP
PVA
loaded
with
Resveratrol
(RSV)
Ampicillin
(AMP)
accelerate
wound
repair.
Results:
Nanofibers
smooth
surfaces
web-like
structures
diameters
ranging
from
200
400
nm
were
successfully
produced
by
electrospinning.
These
fibres
exhibited
excellent
vitro
properties,
ability
absorb
exudates
undergo
biodegradation
over
two-week
period.
Additionally,
these
nanofibers
demonstrated
sustained
controlled
release
encapsulated
through
studies.
zone
inhibition
(ZOI)
PVP-PVA-RSV-AMP
against
Staphylococcus
aureus
(
S.
aureus)
Escherichia
coli
E.
)
was
found
31±
0.09
mm
12±
0.03,
respectively,
which
significantly
higher
as
compared
positive
control.
Similarly,
biofilm
confirmed
significant
reduction
formation
biofilms
nanofiber-treated
group
both
.
X-ray
diffraction
(XRD)
Fourier
transform
infrared
spectroscopy
(FTIR)
analysis
proved
encapsulation
RSV
AMP
into
their
compatibility.
Haemolysis
assay
(%)
showed
no
haemolysis
(less
than
5%)
groups,
cytocompatibility
red
blood
cells
(RBCs).
Cell
viability
cell
adhesion
on
HaCaT
increased
indicating
its
biocompatibility
well
non-toxic
properties.
Results
in-vivo
experiments
model
potential
rats
H&E-stained
images
also
improved
collagen
synthesis
nanofibers-treated
groups
evidenced
Masson-trichrome
staining.
ELISA
clearly
indicated
downregulation
TNF-alpha
IL-6
inflammatory
biomarkers
after
treatment
day
10.
Conclusion:
AMP-loaded
nanofiber
mats,
developed
this
study,
expedite
multifaceted
approach.
Keywords:
electrospinning,
nanofiber,
resveratrol,
ampicillin,
healing,
Язык: Английский
Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles
Pharmaceutics,
Год журнала:
2024,
Номер
16(4), С. 449 - 449
Опубликована: Март 25, 2024
Psoriasis
(PSO)
is
a
chronic
autoimmune
skin
condition
characterized
by
the
rapid
and
excessive
growth
of
cells,
which
leads
to
formation
thick,
red,
scaly
patches
on
surface
skin.
These
can
be
itchy
painful,
they
may
cause
discomfort
for
patients
affected
this
condition.
Therapies
psoriasis
aim
alleviate
symptoms,
reduce
inflammation,
slow
down
cell
growth.
Conventional
topical
treatment
options
are
non-specific,
have
low
efficacy
associated
with
adverse
effects,
why
researchers
investigating
different
delivery
mechanisms.
A
novel
approach
drug
using
nanoparticles
(NPs)
shows
promise
in
reducing
toxicity
improving
therapeutic
efficacy.
The
unique
properties
NPs,
such
as
their
small
size
large
area,
make
them
attractive
targeted
delivery,
enhanced
stability,
controlled
release.
In
context
PSO,
NPs
designed
deliver
active
ingredients
anti-inflammatory
effect,
immunosuppressants,
or
other
compounds
directly
areas.
formulations
offer
improved
access
epidermis
facilitate
better
absorption,
thus
enhancing
conventional
anti-psoriatic
drugs.
increase
surface-to-volume
ratio,
resulting
penetration
through
skin,
including
intracellular,
intercellular,
trans-appendage
routes.
present
review
aims
discuss
latest
approaches
therapy
PSO
NPs.
It
intended
summarize
results
vitro
vivo
examinations
carried
out
last
few
years
regarding
effectiveness
safety
nanoparticles.
Язык: Английский
Topical Therapy in Psoriasis: Clinical Benefits, Advances in Novel Drug Delivery Strategies, and Gene Therapy Regimen
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 283 - 283
Опубликована: Фев. 20, 2025
Psoriasis
is
a
chronic
inflammatory
disease
with
complex
pathogenesis,
influenced
by
various
factors
involving
environment,
genes,
and
immunity.
The
main
symptoms
of
psoriasis
include
erythema,
scales,
itching,
etc.
At
present,
therapeutic
drugs
for
are
continually
evolving
towards
enhancing
treatment
efficacy
reducing
side
effects.
Firstly,
the
pathogenesis
characteristics
were
summarized.
Then,
types
benefits
topical
therapy
introduced,
such
as
aspects
avoiding
systemic
toxic
effects,
first
pass
effect,
gastrointestinal
reactions
accelerating
onset
time
improving
its
efficacy,
compared
to
drugs.
In
case
methotrexate,
cyclosporin
A,
Janus
kinase
(JAK)
inhibitors,
phosphodiesterase-4
(PDE-4)
this
review
had
further
discussion
on
improvement
translation
these
molecules
from
in
clinical
practice.
To
augment
limitation
skin
permeability,
nanotechnology
novel
drug
delivery
system
including
nanomedicines,
hydrogels,
ionic
liquids,
microneedles
elaborated
management.
Also,
exploration
targeting
pathogenic
genes
through
small
interfering
RNA
(siRNA)
using
nanoparticles
liquids
(ILs)
great
significance
long-term
psoriasis.
Taken
together,
development
numerous
platforms
expected
achieve
enhanced
penetration,
precise
efficient
molecule
interference
(RNAi)
therapeutics
prospects.
Язык: Английский
A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125385 - 125385
Опубликована: Фев. 1, 2025
Язык: Английский
Surface entrenched β-sitosterol niosomes for enhanced cardioprotective activity against isoproterenol induced cardiotoxicity in rats
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
653, С. 123872 - 123872
Опубликована: Фев. 8, 2024
Язык: Английский
Curcumin-Based Ionic Liquid Hydrogel for Topical Transdermal Delivery of Curcumin To Improve Its Therapeutic Effect on the Psoriasis Mouse Model
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(14), С. 17080 - 17091
Опубликована: Апрель 1, 2024
Psoriasis
is
a
systemic,
recurrent,
chronic
autoimmune
skin
disease.
However,
psoriasis
drugs
have
poor
permeability
and
high
toxicity,
resulting
in
low
bioavailability
affecting
their
clinical
application.
In
this
study,
we
propose
curcumin-based
ionic
liquid
hydrogel
loaded
with
ilomastat
(Cur-Car-IL@Ilo
hydrogel),
which
can
effectively
maintain
the
sustained
release
of
improve
drugs.
We
used
model
imiquimod-induced
demonstrated
that
local
application
Cur-Car-IL@Ilo
lesions
mice
significantly
reduced
expression
levels
inflammatory
factors,
matrix
metalloproteinase
8,
collagen-I.
The
expressions
iron
death-related
proteins
SLC7A11
ASL4
were
decreased
after
treatment
hydrogel.
Flora
analysis
showed
content
anaerotruncus,
proteus,
UCG-009
bacteria
gut
psoriatic
increased.
paludicola,
parabacteroides,
prevotellaceae_UCG-001,
escherichia-shigella,
aerococcus
decreased,
some
above
tended
to
be
normal
treatment.
Therefore,
as
multifunctional,
nonirritating,
noninvasive,
highly
effective
percutaneous
psoriasis.
Язык: Английский
Synthesis and evaluation of valsartan co-crystals for enhanced solubility and anti-hypertensive activity
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125743 - 125743
Опубликована: Май 1, 2025
Язык: Английский
Evaluation of cardioprotective effect of naringin loaded lignin nanoparticles against isoproterenol induced myocardial infarction
Journal of Drug Delivery Science and Technology,
Год журнала:
2023,
Номер
89, С. 105076 - 105076
Опубликована: Окт. 18, 2023
Язык: Английский
Psoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis
European Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
205, С. 107000 - 107000
Опубликована: Дек. 25, 2024
Blue
light
will
be
a
promising
alternative
for
photodynamic
therapy
in
psoriasis,
but
the
photosensitizer
vivo
remains
unexplored.
Mesoporous
zinc
phosphate
microparticle
(MZP)
was
synthesized
successfully
this
study,
as
evidenced
by
XPS,
XRD,
and
nitrogen
adsorption
experiments.
Its
psoriatic
skin-sensitive
property
corroborated
SEM
higher
cumulative
release
rate
of
that
impregnated
with
curcumin
(Cur)
glycyrrhizic
acid
(GA),
namely
Cur-GA-MZP,
at
pH
5.4,
which
mimic
acidic
environment
inflammatory
skin.
Moreover,
detecting
decrease
absorbance
1,3-Diphenylisobenzofuran
(DPBF)
had
been
mixed
MZP
irradiated
blue
light,
is
confirmed
to
reinforce
ROS
along
irradiation
time
rather
than
7.2.
This
phenomenon
led
strengthened
anti-inflammatory
effect
on
xylene-induced
auricle
inflammation,
well
imiquimod-induced
psoriatic-like
plaques
exists
only
under
irradiation,
alleviated
macroscopic
microscopic
appearance,
decreased
IL-17A
levels
skin
lesion
area
spleen
index.
The
mechanism
likely
attributed
NFƙB
pathway
MAPK
detected
western
blot.
In
sum,
MZP,
could
dissociate
condition,
prerequisite
an
effective
management
psoriasis.
Язык: Английский