Neutralizing tumor-related inflammation and reprogramming of cancer-associated fibroblasts by Curcumin in breast cancer therapy

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 26, 2023

Abstract Tumor-associated inflammation plays a vital role in cancer progression. Among the various stromal cells, cancer-associated fibroblasts are promising targets for therapy. Several reports have indicated potent anti-inflammatory effects attributed to Curcumin. This study aimed investigate whether inhibiting inflammatory function of (CAFs) with Curcumin can restore anticancer immune responses. CAFs were isolated from breast tissues, treated Curcumin, and co-cultured patients' PBMCs evaluate gene expression cytokine production alterations. Blood tumor tissue samples obtained 12 patients stage II/III invasive ductal carcinoma. Fibroblast Activation Protein (FAP) + extracted tissue, 10 μM corresponding PBMCs. The smooth muscle actin-alpha (α-SMA), Cyclooxygenase-2(COX-2), PGE2, cell cytokines evaluated using Real-Time PCR ELISA, respectively. Analyzes showed that treatment decreased genes α-SMA COX-2 PGE2 CAFs. In Curcumin-treated CAFs, FoxP3 along TGF-β, IL-10, IL-4. An increase IFN-γ was observed followed by increased T-bet expression. According our results, could reprogram pro-tumor phenotype anti-tumor Thus, as component microenvironment, suitable target combination immunotherapies cancer.

Language: Английский

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Payload‐free protein nanoparticles target inflamed colons to restore intestinal barrier integrity for effectively treating inflammatory bowel diseases

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 6, 2024

Abstract Anti‐inflammatory compounds, delivered as a payload to the gastrointestinal tract (GIT) by carriers, still cannot treat inflammatory bowel diseases without avoiding side effects. Here, we developed payload‐free protein nanoparticles (PNPs) that crossed GIT retain in colon and colitis restoring intestinal barrier integrity modulating gut microbiome metabolome. Specifically, PNPs, orally administered mice with acute colitis, reached within three hours. Consequently, PNPs improve microbiota dysbiosis reverse metabolism balance, suppressing expression of tumor‐necrosis factor α toll‐like receptor 4 restores integrity. then ameliorated inflammation attenuated exerting probiotic effects on microbiota, treating week more effectively than clinically often used 5‐aminosalicylic acid causing undesired Such represent safe, sustainable, cost‐effective therapeutics for metabolic eliminating microbial metabolomic imbalance.

Language: Английский

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Oral enzyme-responsive nanoprobes for targeted theranostics of inflammatory bowel disease

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 13, 2024

Inflammatory bowel disease (IBD) is a progressive and debilitating inflammatory of the gastrointestinal tract (GIT). Despite recent advances, precise treatment noninvasive monitoring remain challenging.

Language: Английский

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Core-shell structured nanomembrane with sequential immune and vascular isolation effects followed by chondrogenic induction to promote stable stem cell-based subcutaneous cartilage regeneration in large animals

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 154878 - 154878

Published: Aug. 15, 2024

Language: Английский

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Synergistic effects of multidrug/material combination deliver system for anti-mutidrug-resistant tumor

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 649, P. 123669 - 123669

Published: Dec. 4, 2023

Language: Английский

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