Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 23, 2024
Abstract
Bacterial
infection‐induced
excessive
inflammation
is
a
major
obstacle
in
diabetic
wound
healing.
Nitric
oxide
(NO)
exhibits
significant
antibacterial
activity
but
extremely
deficient
diabetes.
Hence,
near‐infrared
(NIR)‐triggered
NO
release
system
constructed
through
codelivery
of
polyarginine
(PArg)
and
gold
nanorods
(Au)
an
NIR‐activatable
methylene
blue
(MB)
polypeptide‐assembled
nanovesicle
(Au/PEL‐PBA‐MB/PArg).
Upon
NIR
irradiation,
the
quenched
MB
nanovesicles
photoactivated
to
generate
more
reactive
oxygen
species
(ROS)
oxidize
PArg
on‐demand
controlled
manner.
With
specific
bacterial
capture
phenylboronic
acid
(PBA),
elevated
membrane
permeability
boosted
vulnerability
photothermal
therapy
(PTT)
Au
nanorods,
which
displayed
by
superior
mild
PTT
against
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
at
temperatures
<
49.7
°C
vitro.
Moreover,
vivo,
greatly
suppressed
burst
MRSA‐induced
inflammation,
relayed
immunomodulated
macrophage
polarization
from
M1
M2,
inflammatory
phase
successfully
transferred
repair
phase.
In
cooperation
with
angiogenesis
NO,
tissue
regeneration
accelerated
MRSA‐infected
wounds.
Therefore,
nanoplatform
has
considerable
potential
for
accelerating
healing
infected
ACS Nano,
Год журнала:
2023,
Номер
17(4), С. 3557 - 3573
Опубликована: Фев. 13, 2023
Nitric
oxide
(NO)
is
drawing
widespread
attention
in
treating
pancreatic
ductal
adenocarcinoma
(PDAC)
as
a
safe
and
therapeutically
efficient
technique
through
modulating
the
dense
fibrotic
stroma
tumor
microenvironment
to
enhance
drug
penetration.
Considerable
NO
nanogenerators
releasing
molecules
have
been
developed
shield
systemic
toxicity
caused
by
free
diffusion
of
gas.
However,
on-demand
controlled
release
chemotherapy
drugs
at
sites
remains
problem
limited
complex
dynamic
microenvironment.
Herein,
we
present
an
ultrasound-responsive
nanoprodrug
CPT-t-R-PEG2000@BaTiO3
(CRB)
which
encapsulates
piezoelectric
nanomaterials
barium
titanate
nanoparticle
(BaTiO3)
with
amphiphilic
prodrug
that
consisted
thioketal
bond
(t)
linked
camptothecin
(CPT)
NO-donor
l-arginine
(R).
Based
on
ultrasound-triggered
piezocatalysis,
BaTiO3
can
continuously
generate
ROS
hypoxic
environment,
induces
cascade
reaction
processes
break
CPT
oxidize
R
NO,
simultaneously
delivering
site.
It
revealed
CRB
shows
uniform
size
distribution,
prolonged
blood
circulation
time,
excellent
targeting
ability.
Moreover,
were
observed
both
vitro
vivo
under
stimulation
ultrasound,
beneficial
depletion
subsequently
enhanced
delivery
efficacy
CPT.
Taken
together,
significantly
increased
antitumor
against
highly
malignant
Panc02
tumors
mice
inhibiting
chemoresistance,
representing
feasible
approach
for
targeted
therapies
other
PDAC.
Wound
repair,
particularly
chronic
nonhealing
wound
is
a
global
health
issue
that
affects
millions
of
people
worldwide.
As
an
effective
and
safe
therapeutic
reagent,
gas
molecules
in
tissue
repair
have
attracted
considerable
attention.
Recent
studies
shown
therapy
(GT)
plays
essential
role
all
phases
including
anti‐inflammatory
antimicrobial
modulation,
cell
proliferation
migration,
proangiogenesis,
extracellular
matrix
remodeling.
This
review
aims
to
summarize
recent
progress
developing
GT
for
repair.
The
characteristics
with
functions,
such
as
oxygen,
nitric
oxide,
carbon
monoxide,
hydrogen
sulfide,
others
(such
sulfur
dioxide,
hydrogen,
plasma)
healing
are
introduced.
has
transitioned
from
pure
gases
inorganic/organic
materials
gas‐releasing
materials,
gas‐producing
gas‐loaded
controlled/long‐lasting
stable‐releasing
biomaterials.
Finally,
the
limitations
prospects
field
analyzed
summarized.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 29, 2025
The
challenges
associated
with
prolonged
healing
or
non-healing
of
chronic
diabetic
wounds
contribute
significantly
to
the
increased
incidence
lower
limb
amputation.
A
pivotal
factor
in
impediment
is
reduced
production
endogenous
nitric
oxide
(NO)
due
hyperglycemic
microenvironment
typical
diabetes.
While
both
and
exogenous
NO
have
been
shown
promote
process
wounds,
direct
application
wound
management
limited
its
gaseous
nature
risk
explosive
release.
This
review
summarizes
recent
advances
nanodressings
incorporating
donors
treatment
detailing
specific
conditions
under
which
these
facilitate
release,
a
focus
on
beneficial
effects
NO,
strategies
for
supplementation,
encountered
clinical
translation
as
clinically
viable
nanomedicine
context
improving
healing.
