Medical Gas Research,
Journal Year:
2024,
Volume and Issue:
15(1), P. 23 - 35
Published: July 25, 2024
Non-healing
wounds
are
long-term
complications
of
diabetes
mellitus
(DM)
that
increase
mortality
risk
and
amputation-related
disability
decrease
the
quality
life.
Nitric
oxide
(NO·)-based
treatments
(i.e.,
use
both
systemic
topical
NO·
donors,
precursors,
inducers)
have
received
more
attention
as
complementary
approaches
in
DM
wounds.
Here,
we
aimed
to
highlight
potential
benefits
NO·-based
on
through
a
literature
review
experimental
clinical
evidence.
Various
been
used.
In
rodents,
therapy
facilitates
wound
healing,
manifested
an
increased
healing
rate
decreased
half-closure
time.
The
effect
is
attributed
increasing
local
blood
flow,
angiogenesis
induction,
collagen
synthesis
deposition,
re-epithelization,
anti-inflammatory
anti-oxidative
properties,
potent
broad-spectrum
antibacterial
effects.
existing
lacks
human
evidence
safety
efficacy
for
Translating
favors
into
practice
needs
conducting
trials
with
well-predefined
sizes,
i.e.,
reduction
area,
hospital
length
stay.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(4), P. 3557 - 3573
Published: Feb. 13, 2023
Nitric
oxide
(NO)
is
drawing
widespread
attention
in
treating
pancreatic
ductal
adenocarcinoma
(PDAC)
as
a
safe
and
therapeutically
efficient
technique
through
modulating
the
dense
fibrotic
stroma
tumor
microenvironment
to
enhance
drug
penetration.
Considerable
NO
nanogenerators
releasing
molecules
have
been
developed
shield
systemic
toxicity
caused
by
free
diffusion
of
gas.
However,
on-demand
controlled
release
chemotherapy
drugs
at
sites
remains
problem
limited
complex
dynamic
microenvironment.
Herein,
we
present
an
ultrasound-responsive
nanoprodrug
CPT-t-R-PEG2000@BaTiO3
(CRB)
which
encapsulates
piezoelectric
nanomaterials
barium
titanate
nanoparticle
(BaTiO3)
with
amphiphilic
prodrug
that
consisted
thioketal
bond
(t)
linked
camptothecin
(CPT)
NO-donor
l-arginine
(R).
Based
on
ultrasound-triggered
piezocatalysis,
BaTiO3
can
continuously
generate
ROS
hypoxic
environment,
induces
cascade
reaction
processes
break
CPT
oxidize
R
NO,
simultaneously
delivering
site.
It
revealed
CRB
shows
uniform
size
distribution,
prolonged
blood
circulation
time,
excellent
targeting
ability.
Moreover,
were
observed
both
vitro
vivo
under
stimulation
ultrasound,
beneficial
depletion
subsequently
enhanced
delivery
efficacy
CPT.
Taken
together,
significantly
increased
antitumor
against
highly
malignant
Panc02
tumors
mice
inhibiting
chemoresistance,
representing
feasible
approach
for
targeted
therapies
other
PDAC.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 29, 2025
The
challenges
associated
with
prolonged
healing
or
non-healing
of
chronic
diabetic
wounds
contribute
significantly
to
the
increased
incidence
lower
limb
amputation.
A
pivotal
factor
in
impediment
is
reduced
production
endogenous
nitric
oxide
(NO)
due
hyperglycemic
microenvironment
typical
diabetes.
While
both
and
exogenous
NO
have
been
shown
promote
process
wounds,
direct
application
wound
management
limited
its
gaseous
nature
risk
explosive
release.
This
review
summarizes
recent
advances
nanodressings
incorporating
donors
treatment
detailing
specific
conditions
under
which
these
facilitate
release,
a
focus
on
beneficial
effects
NO,
strategies
for
supplementation,
encountered
clinical
translation
as
clinically
viable
nanomedicine
context
improving
healing.
Small Structures,
Journal Year:
2023,
Volume and Issue:
5(1)
Published: Sept. 27, 2023
Wound
repair,
particularly
chronic
nonhealing
wound
is
a
global
health
issue
that
affects
millions
of
people
worldwide.
As
an
effective
and
safe
therapeutic
reagent,
gas
molecules
in
tissue
repair
have
attracted
considerable
attention.
Recent
studies
shown
therapy
(GT)
plays
essential
role
all
phases
including
anti‐inflammatory
antimicrobial
modulation,
cell
proliferation
migration,
proangiogenesis,
extracellular
matrix
remodeling.
This
review
aims
to
summarize
recent
progress
developing
GT
for
repair.
The
characteristics
with
functions,
such
as
oxygen,
nitric
oxide,
carbon
monoxide,
hydrogen
sulfide,
others
(such
sulfur
dioxide,
hydrogen,
plasma)
healing
are
introduced.
has
transitioned
from
pure
gases
inorganic/organic
materials
gas‐releasing
materials,
gas‐producing
gas‐loaded
controlled/long‐lasting
stable‐releasing
biomaterials.
Finally,
the
limitations
prospects
field
analyzed
summarized.
