Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115117 - 115117
Опубликована: Окт. 26, 2023
Язык: Английский
Molecules, Год журнала: 2024, Номер 29(15), С. 3482 - 3482
Опубликована: Июль 25, 2024
Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for modifications have enabled their use in a wide range of applications. Various factors influence the applications NPs, including synthesis method physical attributes such as size shape. Additionally, materials used NPs primary determinants application. Based on chosen material, generally classified into three categories: organic, inorganic, carbon-based. These categories include variety materials, proteins, polymers, metal ions, lipids derivatives, magnetic minerals, so on. Each material possesses activity application NPs. Consequently, certain typically particular areas because they higher efficiency along tenable toxicity. Therefore, classification base NP hold significant importance both research In this paper, we discuss these classifications, exemplify most major categorize them according preferred area This review provides an overall application,
Язык: Английский
Процитировано
28
Carbohydrate Polymers, Год журнала: 2024, Номер unknown, С. 121926 - 121926
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
18
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139177 - 139177
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Coordination Chemistry Reviews, Год журнала: 2023, Номер 502, С. 215615 - 215615
Опубликована: Дек. 20, 2023
Язык: Английский
Процитировано
38
Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 820 - 820
Опубликована: Март 2, 2023
Drug degradation at low pH and rapid clearance from intestinal absorption sites are the main factors limiting development of oral macromolecular delivery systems. Based on responsiveness mucosal adhesion hyaluronic acid (HA) poly[2-(dimethylamino)ethyl methacrylate] (PDM), we prepared three HA-PDM nano-delivery systems loaded with insulin (INS) using different molecular weights (MW) HA (L, M, H), respectively. The types nanoparticles (L/H/M-HA-PDM-INS) had uniform particle sizes negatively charged surfaces. optimal drug loadings L-HA-PDM-INS, M-HA-PDM-INS, H-HA-PDM-INS were 8.69 ± 0.94%, 9.11 1.03%, 10.61 1.16% (w/w), structural characteristics HA-PDM-INS determined FT-IR, effect MW properties was investigated. release INS 22.01 3.84% 1.2 63.23 4.10% 7.4. protective ability against verified by circular dichroism spectroscopy protease resistance experiments. retained 45.67 5.03% 2 h. biocompatibility HA-PDM-INS, regardless HA, demonstrated CCK-8 live-dead cell staining. Compared solution, transport efficiencies increased 4.16, 3.81, 3.10 times, In vivo pharmacodynamic pharmacokinetic studies performed in diabetic rats following administration. exhibited an effective hypoglycemic over a long period, relative bioavailability 14.62%. conclusion, these simple, environmentally friendly, pH-responsive, mucoadhesive have potential for industrial development. This study provides preliminary data support delivery.
Язык: Английский
Процитировано
27
Journal of Controlled Release, Год журнала: 2023, Номер 360, С. 514 - 527
Опубликована: Июль 12, 2023
Язык: Английский
Процитировано
26
Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 431 - 431
Опубликована: Март 21, 2024
The intestine is essential for the modulation of nutrient absorption and removal waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable syndrome (IBS), celiac disease, which extensively impact gut functions, are thus critical human health. Targeted drug delivery to tackle these diseases, improve therapy efficacy, minimize side effects. Recent strategies have taken advantage both active passive nanocarriers, designed protect until it reaches correct site modulate release via use different physical–chemical strategies. In this systematic review, we present a literature overview nanocarriers used in set chronic intestinal highlighting rationale behind controlled therapies. overall aim provide reader with useful information on current approaches targeting novel therapeutic
Язык: Английский
Процитировано
15
Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 668 - 683
Опубликована: Янв. 18, 2024
Язык: Английский
Процитировано
9
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер 207, С. 114633 - 114633
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 229 - 229
Опубликована: Фев. 10, 2025
Skin disorders are the fourth most common cause of all diseases, which affect nearly one-third world’s population. Topical drug delivery can be effective in treating a range skin disorders, including microbial infections, cancer, dermatitis, burn injury, wounds, and psoriasis. Bioadhesive nanoparticles (BNPs) serve as an efficient topical system they dual purposes bioadhesives nanocarriers, mediate targeted delivery, prolong retention time, deepen penetration through layers. There is increasing demand for BNP-based applications medicine because their various advantages, biodegradability, flexibility, biocompatibility, enhanced adhesive strength. A number BNPs have already been developed evaluated potential systems. In addition, studies carried out to evaluate treatment atopic irritant contact psoriasis, severe injuries. This review article timely unique, it provides extensive unique summary recent advances wide-ranging disorders. Moreover, this also useful discussion on bioadhesion mechanism biopolymers that used prepare BNPs.
Язык: Английский
Процитировано
1