Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115117 - 115117
Published: Oct. 26, 2023
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3482 - 3482
Published: July 25, 2024
Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for modifications have enabled their use in a wide range of applications. Various factors influence the applications NPs, including synthesis method physical attributes such as size shape. Additionally, materials used NPs primary determinants application. Based on chosen material, generally classified into three categories: organic, inorganic, carbon-based. These categories include variety materials, proteins, polymers, metal ions, lipids derivatives, magnetic minerals, so on. Each material possesses activity application NPs. Consequently, certain typically particular areas because they higher efficiency along tenable toxicity. Therefore, classification base NP hold significant importance both research In this paper, we discuss these classifications, exemplify most major categorize them according preferred area This review provides an overall application,
Language: Английский
Citations
28
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: unknown, P. 121926 - 121926
Published: Feb. 1, 2024
Language: Английский
Citations
18
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139177 - 139177
Published: Jan. 1, 2025
Language: Английский
Citations
3
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215615 - 215615
Published: Dec. 20, 2023
Language: Английский
Citations
38
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 820 - 820
Published: March 2, 2023
Drug degradation at low pH and rapid clearance from intestinal absorption sites are the main factors limiting development of oral macromolecular delivery systems. Based on responsiveness mucosal adhesion hyaluronic acid (HA) poly[2-(dimethylamino)ethyl methacrylate] (PDM), we prepared three HA-PDM nano-delivery systems loaded with insulin (INS) using different molecular weights (MW) HA (L, M, H), respectively. The types nanoparticles (L/H/M-HA-PDM-INS) had uniform particle sizes negatively charged surfaces. optimal drug loadings L-HA-PDM-INS, M-HA-PDM-INS, H-HA-PDM-INS were 8.69 ± 0.94%, 9.11 1.03%, 10.61 1.16% (w/w), structural characteristics HA-PDM-INS determined FT-IR, effect MW properties was investigated. release INS 22.01 3.84% 1.2 63.23 4.10% 7.4. protective ability against verified by circular dichroism spectroscopy protease resistance experiments. retained 45.67 5.03% 2 h. biocompatibility HA-PDM-INS, regardless HA, demonstrated CCK-8 live-dead cell staining. Compared solution, transport efficiencies increased 4.16, 3.81, 3.10 times, In vivo pharmacodynamic pharmacokinetic studies performed in diabetic rats following administration. exhibited an effective hypoglycemic over a long period, relative bioavailability 14.62%. conclusion, these simple, environmentally friendly, pH-responsive, mucoadhesive have potential for industrial development. This study provides preliminary data support delivery.
Language: Английский
Citations
27
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 514 - 527
Published: July 12, 2023
Language: Английский
Citations
26
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 431 - 431
Published: March 21, 2024
The intestine is essential for the modulation of nutrient absorption and removal waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable syndrome (IBS), celiac disease, which extensively impact gut functions, are thus critical human health. Targeted drug delivery to tackle these diseases, improve therapy efficacy, minimize side effects. Recent strategies have taken advantage both active passive nanocarriers, designed protect until it reaches correct site modulate release via use different physical–chemical strategies. In this systematic review, we present a literature overview nanocarriers used in set chronic intestinal highlighting rationale behind controlled therapies. overall aim provide reader with useful information on current approaches targeting novel therapeutic
Language: Английский
Citations
15
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 668 - 683
Published: Jan. 18, 2024
Language: Английский
Citations
9
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: 207, P. 114633 - 114633
Published: Jan. 14, 2025
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 229 - 229
Published: Feb. 10, 2025
Skin disorders are the fourth most common cause of all diseases, which affect nearly one-third world’s population. Topical drug delivery can be effective in treating a range skin disorders, including microbial infections, cancer, dermatitis, burn injury, wounds, and psoriasis. Bioadhesive nanoparticles (BNPs) serve as an efficient topical system they dual purposes bioadhesives nanocarriers, mediate targeted delivery, prolong retention time, deepen penetration through layers. There is increasing demand for BNP-based applications medicine because their various advantages, biodegradability, flexibility, biocompatibility, enhanced adhesive strength. A number BNPs have already been developed evaluated potential systems. In addition, studies carried out to evaluate treatment atopic irritant contact psoriasis, severe injuries. This review article timely unique, it provides extensive unique summary recent advances wide-ranging disorders. Moreover, this also useful discussion on bioadhesion mechanism biopolymers that used prepare BNPs.
Language: Английский
Citations
1