Materials Today Bio,
Год журнала:
2023,
Номер
20, С. 100673 - 100673
Опубликована: Июнь 1, 2023
Glioma
is
one
of
the
most
serious
central
nervous
system
diseases,
with
high
mortality
and
poor
prognosis.
Despite
continuous
development
existing
treatment
methods,
median
survival
time
glioma
patients
still
only
15
months.
The
main
difficulties
are
invasive
growth
obstruction
blood-brain
barrier
(BBB)
to
drugs.
With
rapid
advancements
in
nanotechnology,
inorganic
nanoparticles
(INPs)
have
shown
favourable
application
prospects
diagnosis
glioma.
Due
their
extraordinary
intrinsic
features,
INPs
can
be
easily
fabricated,
while
doping
other
elements
surface
modification
by
biological
ligands
used
enhance
BBB
penetration,
targeted
delivery
biocompatibility.
Guided
theranostics
improve
efficacy
traditional
methods
such
as
chemotherapy,
radiotherapy
gene
therapy.
New
strategies,
immunotherapy,
photothermal
photodynamic
therapy,
magnetic
hyperthermia
multifunctional
nanoplatforms,
also
been
facilitated
INPs.
This
review
emphasizes
current
state
research
clinical
applications
INPs,
including
targeting
penetration
enhancement
vivo
vitro
biocompatibility,
diagnostic
strategies.
As
such,
it
provides
insights
for
novel
Abstract
Photodynamic
therapy
(PDT)
has
recently
been
considered
a
potential
tumor
due
to
its
time‐space
specificity
and
non‐invasive
advantages.
PDT
can
not
only
directly
kill
cells
by
using
cytotoxic
reactive
oxygen
species
but
also
induce
an
anti‐tumor
immune
response
causing
immunogenic
cell
death
of
cells.
Although
it
exhibits
promising
prospect
in
treating
tumors,
there
are
still
many
problems
be
solved
practical
application.
Tumor
hypoxia
immunosuppressive
microenvironment
seriously
affect
the
efficacy
PDT.
The
hypoxic
is
mainly
abnormal
vascular
matrix
around
tumor,
metabolism,
influence
various
immunosuppressive‐related
their
expressed
molecules.
Thus,
reprogramming
(TME)
great
significance
for
rejuvenating
This
article
reviews
latest
strategies
PDT,
from
regulating
matrix,
interfering
with
related
factors
reverse
microenvironment.
These
provide
valuable
information
better
understanding
TME
guide
development
next‐generation
multifunctional
nanoplatforms
Diagnostics,
Год журнала:
2023,
Номер
13(5), С. 833 - 833
Опубликована: Фев. 22, 2023
In
recent
years,
there
has
been
an
increasing
interest
in
using
nanoparticles
the
medical
sciences.
Today,
metal
have
many
applications
medicine
for
tumor
visualization,
drug
delivery,
and
early
diagnosis,
with
different
modalities
such
as
X-ray
imaging,
computed
tomography
(CT),
magnetic
resonance
imaging
(MRI),
positron
emission
(PET),
etc.,
treatment
radiation.
This
paper
reviews
findings
of
nanotheranostics
therapy.
The
study
offers
some
critical
insights
into
types
cancer
detection
purposes.
data
this
review
were
gathered
from
multiple
scientific
citation
websites
Google
Scholar,
PubMed,
Scopus,
Web
Science
up
through
end
January
2023.
literature,
are
used
applications.
However,
due
to
their
high
abundance,
low
price,
performance
visualization
treatment,
gold,
bismuth,
tungsten,
tantalum,
ytterbium,
gadolinium,
silver,
iron,
platinum,
lead
investigated
study.
highlighted
importance
iron-based
forms
ease
functionalization,
toxicity,
superior
biocompatibility.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(17)
Опубликована: Фев. 19, 2023
Traditional
dendritic
cell
(DC)-mediated
immunotherapy
is
usually
suppressed
by
weak
immunogenicity
in
tumors
and
generally
leads
to
unsatisfactory
outcomes.
Synergistic
exogenous/endogenous
immunogenic
activation
can
provide
an
alternative
strategy
for
evoking
a
robust
immune
response
promoting
DC
activation.
Herein,
Ti
Journal of Controlled Release,
Год журнала:
2024,
Номер
366, С. 375 - 394
Опубликована: Янв. 9, 2024
Pyroptosis
is
a
specific
type
of
programmed
cell
death
(PCD)
characterized
by
distinct
morphological
changes,
including
swelling,
membrane
blebbing,
DNA
fragmentation,
and
eventual
lysis.
closely
associated
with
human-related
diseases,
such
as
inflammation
malignancies.
Since
the
initial
observation
pyroptosis
in
Shigella
flexneri-infected
macrophages
more
than
20
years
ago,
various
pyroptosis-inducing
agents,
ions,
small
molecules,
biological
nanomaterials,
have
been
developed
for
tumor
treatment.
Given
that
can
activate
body's
robust
immune
response
against
promote
formation
long-term
memory
treatment,
its
status
immunogenic
self-evident.
Therefore,
should
be
used
powerful
anti-tumor
strategy.
However,
there
still
lack
comprehensive
summary
most
recent
advances
pyroptosis-based
cancer
therapy.
it
vital
to
fill
this
gap
inspire
future
drug
design
better
induce
cells
undergo
achieve
advanced
effects.
In
review,
we
summarize
detail
triggering
adequate
clearance
based
on
treatment
modalities,
highlight
material
therapeutic
advantages.
Besides,
also
provide
an
outlook
prospects
emerging
field
next
development.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 4087 - 4101
Опубликована: Июнь 3, 2024
Currently,
the
efficacy
of
albumin-bound
paclitaxel
(PTX@Alb)
is
still
limited
due
to
impaired
PTX@Alb
accumulation
in
tumors
partly
mediated
by
dense
collagen
distribution.
Meanwhile,
acquired
immune
resistance
always
occurs
enhanced
programmed
cell
death-ligand
1
(PD-L1)
expression
after
treatment,
which
then
leads
tolerance.
To
fill
these
gaps,
we
newly
revealed
that
tamoxifen
(TAM),
a
clinically
widely
used
adjuvant
therapy
for
breast
cancer
with
mitochondrial
metabolism
blockade
capacity,
could
also
be
as
novel
effective
PD-L1
and
TGF-
Abstract
Photodynamic
therapy
(PDT)
is
a
minimally
invasive
and
controllable
local
cancer
treatment
for
cholangiocarcinoma
(CCA).
However,
the
efficacy
of
PDT
hindered
by
intratumoral
hypoxia
presence
an
antioxidant
microenvironment.
To
address
these
limitations,
combining
with
gas
may
be
promising
strategy
to
enhance
tumor
oxygenation.
Moreover,
augmentation
oxidative
damage
induced
can
achieved
inhibiting
NRF2,
core
regulatory
molecule
involved
in
response.
In
this
study,
integrated
nanotherapeutic
platform
called
CMArg@Lip,
incorporating
therapies
using
ROS‐responsive
liposomes
encapsulating
photosensitizer
Ce6,
NO
gas‐generating
agent
L‐arginine,
NRF2
inhibitor
ML385,
successfully
developed.
The
utilization
CMArg@Lip
effectively
deals
challenges
posed
microenvironment,
resulting
elevated
levels
subsequent
induction
ferroptosis
CCA.
Additionally,
findings
suggest
that
exhibits
notable
immunomodulatory
effects,
including
promotion
immunogenic
cell
death
facilitation
dendritic
maturation.
Furthermore,
it
contributes
anti‐tumor
function
cytotoxic
T
lymphocytes
through
downregulation
PD‐L1
expression
cells
activation
STING
signaling
pathway
myeloid‐derived
suppressor
cells,
thereby
reprogramming
immunosuppressive
microenvironment
via
various
mechanisms.
