ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 2637 - 2659
Опубликована: Апрель 30, 2024
Extensive
research
has
been
conducted
on
the
application
of
nanoparticles
in
treatment
cancer
and
infectious
diseases.
Due
to
their
exceptional
characteristics
flexible
structure,
they
are
classified
as
highly
efficient
drug
delivery
systems,
ensuring
both
safety
targeted
delivery.
Nevertheless,
still
encounter
obstacles,
such
biological
instability,
absence
selectivity,
recognition
unfamiliar
elements,
quick
elimination,
which
restrict
remedial
capacity.
To
surmount
these
drawbacks,
biomimetic
nanotechnology
developed
that
utilizes
T
cell
natural
killer
(NK)
membrane-encased
sophisticated
methods
administering
drugs.
These
can
extend
duration
circulation
avoid
immune
system
clearance.
During
membrane
extraction
coating
procedure,
surface
proteins
immunological
cells
transferred
nanoparticles.
Such
present
confer
several
benefits
nanoparticles,
including
prolonged
circulation,
enhanced
targeting,
controlled
release,
specific
cellular
contact,
reduced
vivo
toxicity.
This
review
focuses
nanosystems
derived
from
membranes
NK
comprehensive
manufacture,
applications
viral
infections.
Furthermore,
potential
applications,
prospects,
existing
challenges
medical
implementation
highlighted.
Medicinal Research Reviews,
Год журнала:
2023,
Номер
43(6), С. 2115 - 2176
Опубликована: Май 11, 2023
Abstract
Breast
cancer
is
the
most
malignant
tumor
in
women,
and
there
no
absolute
cure
for
it.
Although
treatment
modalities
including
surgery,
chemotherapy,
radiotherapy
are
utilized
breast
cancer,
it
still
a
life‐threatening
disease
humans.
Nanomedicine
has
provided
new
opportunity
treatment,
which
focus
of
current
study.
The
nanocarriers
deliver
chemotherapeutic
agents
natural
products,
both
increase
cytotoxicity
against
cells
prevent
development
drug
resistance.
efficacy
gene
therapy
boosted
by
nanoparticles
delivery
CRISPR/Cas9,
Noncoding
RNAs,
RNAi,
promoting
their
potential
expression
regulation.
codelivery
can
exert
synergistic
impact
on
tumors
enhance
cellular
uptake
via
endocytosis.
Nanostructures
able
to
induce
photothermal
photodynamic
ablation
cell
death
induction.
provide
microenvironment
remodeling
repolarization
macrophages
antitumor
immunity.
stimuli‐responsive
nanocarriers,
pH‐,
redox‐,
light‐sensitive,
mediate
targeted
suppression
tumors.
Besides,
diagnosis
detect
biomarkers.
Various
kinds
have
been
employed
therapy,
carbon‐,
lipid‐,
polymeric‐
metal‐based
nanostructures,
different
terms
biocompatibility
efficiency.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(2), С. 784 - 792
Опубликована: Янв. 24, 2023
Radiation
therapy
has
demonstrated
promising
effectiveness
against
several
types
of
cancers.
X-ray
radiation
can
be
made
further
effective
by
utilizing
nanoparticles
high-atomic-number
(high-Z)
materials
that
act
as
radiosensitizers.
Here,
in
purpose
maximizing
the
within
tumors,
bovine
serum
albumin
capped
gadolinium
oxide
and
gold
(Gd2O3@BSA-Au
NPs)
are
developed
a
bimetallic
radiosensitizer.
In
this
study,
we
incorporate
two
high-Z-based
nanoparticles,
Au
Gd,
single
nanoplatform.
The
radiosensitizing
ability
was
assessed
with
series
vitro
tests,
following
evaluation
vivo
breast
cancer
murine
model.
Enhanced
tumor
suppression
is
observed
group
received
after
administration
Gd2O3@BSA-Au
NPs.
As
result,
efficacy
significantly
improved
applying
NPs
under
irradiation,
evidenced
studies
evaluating
cell
viability,
proliferation,
reactive
oxygen
species
production,
anti-tumor
effect.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 571 - 608
Опубликована: Янв. 1, 2024
Abstract:
With
the
development
of
nanotechnology,
nanoparticles
(NPs)
have
shown
broad
prospects
as
drug
delivery
vehicles.
However,
they
exhibit
certain
limitations,
including
low
biocompatibility,
poor
physiological
stability,
rapid
clearance
from
body,
and
nonspecific
targeting,
which
hampered
their
clinical
application.
Therefore,
novel
systems
with
improved
biocompatibility
high
target
specificity
remains
a
major
challenge.
In
recent
years,
biofilm
mediated
biomimetic
nano-drug
system
(BNDDS)
has
become
research
hotspot
focus
in
field
life
sciences.
This
new
platform
uses
bio-nanotechnology
to
encapsulate
synthetic
NPswithin
membrane,
organically
integrating
immunogenicity,
toxicity,
tumor
good
adjustability
versatility
nanocarrier,
shows
promising
applications
precision
therapy.
this
review,
we
systematically
summarize
progress
BNDDS
used
for
optimizing
delivery,
providing
theoretical
reference
designing
safe
efficient
treatment
strategies
improve
outcomes.
Keywords:
nanoparticles,
cell
targeted
therapy
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(13), С. 15718 - 15729
Опубликована: Март 20, 2024
Surgical
removal
of
tumor
tissue
remains
the
primary
clinical
approach
for
addressing
breast
cancer;
however,
complete
excision
is
challenging,
and
remaining
cells
can
lead
to
recurrence
metastasis
over
time,
which
substantially
deteriorates
life
quality
patients.
With
aim
improve
local
cancer
radiotherapy,
this
work
reports
fabrication
alginate
(Alg)
scaffolds
containing
bovine
serum
albumin
(BSA)-coated
bismuth
sulfide
(Bi2S3@BSA)
nanoradiosensitizers
using
three-dimensional
(3D)
printing.
Under
single-dose
X-ray
irradiation
in
vitro,
Alg-Bi2S3@BSA
significantly
increase
formation
reactive
oxygen
species,
enhance
inhibition
cells,
suppress
their
colony
capacity.
In
addition,
implanted
under
murine
model
show
high
therapeutic
efficacy
by
reducing
volume
growth
rate
irradiation,
while
histological
observation
main
organs
reveals
no
cytotoxicity
or
side
effects.
3D-printed
produced
with
biocompatible
biodegradable
materials
may
potentially
lower
rates
patients
inhibiting
residual
following
postsurgery
as
well
exhibit
anticancer
properties
other
solid
tumors.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(3), С. 1019 - 1031
Опубликована: Март 2, 2023
Although
chemotherapy
is
regarded
as
an
essential
option
in
cancer
treatment,
it
still
far
from
being
perfect.
Inadequate
tumor
drug
concentration
and
systemic
toxicity
along
with
broad
biodistribution
have
diminished
the
utility
of
chemotherapy.
Tumor-targeting
peptide-conjugated
multifunctional
nanoplatforms
emerged
effective
strategy
for
site-directed
tissues
treatment
imaging.
Herein,
Pep42-targeted
iron
oxide
magnetic
nanoparticles
(IONPs)
functionalized
β-cyclodextrin
(ßCD)
containing
doxorubicin
(DOX)
(Fe3O4-ßCD-Pep42-DOX)
were
successfully
developed.
The
physical
effects
prepared
NPs
characterized
by
employing
various
techniques.
Transmission
electron
microscopy
(TEM)
images
disclosed
that
developed
Fe3O4-ßCD-Pep42-DOX
had
a
spherical
morphology
core–shell
structure
size
nearly
17
nm.
Fourier
transform
infrared
(FT-IR)
spectroscopy
showed
β-cyclodextrin,
DOX,
Pep42
molecules
loaded
on
IONPs.
In
vitro
cytotoxicity
analysis
revealed
fabricated
Fe3O4-ßCD-Pep42
possessed
excellent
biosafety
toward
BT-474,
MDA-MB468
(cancerous
cells),
MCF10A
normal
cells,
while
exhibited
great
cell
killing
ability.
high
cellular
uptake
intracellular
trafficking
highlights
usefulness
Pep42-targeting
peptide.
vivo
results
strongly
supported
results,
i.e.,
significant
reduction
was
observed
single-dose
injection
into
tumor-bearing
mice.
Interestingly,
MR
imaging
(MRI)
T2
contrast
improvement
cells
therapeutic
ability
theranostics.
Taken
together,
these
findings
provided
strong
evidence
potential
capability
nanoplatform
therapy
opens
up
new
avenue
research
this
area.
